Would For-profit benefit rather than destroy Non-profit? Balance in China’s Social Entrepreneurship Management

Theory and practice of social entrepreneurship are both growing rapidly and attracting increasing attention from a number of different domains, such as non-profits, for-profits, and the public sectors. Social entrepreneurship differs from traditional understanding of business entrepreneurship or non-profit organizations. Social entrepreneurs face barriers to achieve success both in business and social sector which get into more challenges. Facing social entrepreneurship failures, first, we isolated for-profit and non-profit compositions to better our understanding of internal processes. Then the primary question is whether for-profit activities would benefit non-profit or destroy the social purpose. We established a hypotheses framework by case studies which identified three tensions between for-profit and non-profit: T1. Ambidexterity: Differentiation or Integration; T2. Resource Allocation: Short-term versus Long-term; T3. Social Changes: Stability versus Adaptability. In this article, three identified tensions from social entrepreneurship practice would give theoretical structure to public field and increase better performance. Keywords: Social Entrepreneurship/Enterprise, Balance Tensions, Non-profit Managemen

Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment.

Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge for drug transportation. In tumour microenvironment, pPhD NPs responsively transform to full API nanotheranostics with ultra-small size and higher surface charge, which dramatically facilitate the tumour penetration and cell internalisation. pPhD NPs enable visualisation of biodistribution by near-infrared fluorescence imaging, tumour accumulation and therapeutic effect by magnetic resonance imaging. Moreover, the synergistic photothermal-, photodynamic- and chemo-therapies achieve a 100% complete cure rate on both subcutaneous and orthotopic oral cancer models. This nanoplatform with powerful delivery efficiency and versatile theranostic functions shows enormous potentials to improve cancer treatment

Re-examining the premise of isobaric collisions and a novel method to measure the chiral magnetic effect

In these proceedings we show that the premise of the isobaric and collisions to search for the chiral magnetic effect (CME) may not hold as originally anticipated due to large uncertainties in the isobaric nuclear structures. We demonstrate this using Woods-Saxon densities and the proton and neutron densities calculated by the density functional theory. Furthermore, a novel method is proposed to gauge background and possible CME contributions in the same system, intrinsically better than the isobaric collisions of two different systems. We illustrate the method with Monte Carlo Glauber and AMPT (A Multi-Phase Transport) simulations

Varying the Chiral Magnetic Effect Relative to Flow in a Single Nucleus-Nucleus Collision

We propose a novel method to search for the chiral magnetic effect (CME) in heavy ion collisions. We argue that the relative strength of the magnetic field (mainly from spectator protons and responsible for the CME) with respect to the reaction plane and the participant plane is opposite to that of the elliptic flow background arising from the fluctuating participant geometry. This opposite behavior in a single collision system, hence with small systematic uncertainties, can be exploited to extract the possible CME signal from the flow background. The method is applied to the existing data at RHIC, the outcome of which is discussed.Comment: 7 Revtex pages, 3 figures. Accepted by Chinese Physics

Importance of Isobar Density Distributions on the Chiral Magnetic Effect Search

Under the approximate chiral symmetry restoration, quark interactions with topological gluon fields in quantum chromodynamics can induce chirality imbalance and parity violation in local domains. An electric charge separation ({\sc cs}) could be generated along the direction of a strong magnetic field ({\bf B}), a phenomenon called the chiral magnetic effect ({\sc cme}). {\sc cs} measurements by azimuthal correlators are contaminated by a major background from elliptic flow anisotropy ($v_2$). Isobaric $^{96}_{44}$Ru+$^{96}_{44}$Ru and $^{96}_{40}$Zr+$^{96}_{40}$Zr collisions have been proposed to identify the {\sc cme} (expected to differ between the two systems) out of the background (expected to be almost the same). We show, by using the density-functional calculated proton and neutron distributions, that these expectations may not hold as originally anticipated, because the two systems may have sizable differences in eccentricity and $v_2$ and because their difference in {\bf B} may suffer from large uncertainties.Comment: 6 pages, 4 figures. v2: Now the magnetic field averaged over the overlap area is presented, instead of that at the single point at the overlap center in the previous version. v3: published versio

Epigenetic control of translation checkpoint and tumor progression via RUVBL1-EEF1A1 axis

Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of epigenetics- and complex-focused CRISPR screens, RUVBL1, the ATPase component of NuA4 histone acetyltransferase complex, is identified to be essential for EwS tumor progression. Suppression of RUVBL1 leads to attenuated tumor growth, loss of histone H4 acetylation, and ablated MYC signaling. Mechanistically, RUVBL1 controls MYC chromatin binding and modulates the MYC-driven EEF1A1 expression and thus protein synthesis. High-density CRISPR gene body scan pinpoints the critical MYC interacting residue in RUVBL1. Finally, this study reveals the synergism between RUVBL1 suppression and pharmacological inhibition of MYC in EwS xenografts and patient-derived samples. These results indicate that the dynamic interplay between chromatin remodelers, oncogenic transcription factors, and protein translation machinery can provide novel opportunities for combination cancer therapy.</p

Revisit to the yield ratio of triton and 3^3He as an indicator of neutron-rich neck emission

The neutron rich neck zone created in heavy ion reaction is experimentally probed by the production of the $A=3$ isobars. The energy spectra and angular distributions of triton and $^3$He are measured with the CSHINE detector in $^{86}$Kr +$^{208}$Pb reactions at 25 MeV/u. While the energy spectrum of $^{3}$He is harder than that of triton, known as "$^{3}$He-puzzle", the yield ratio $R({\rm t/^3He})$ presents a robust rising trend with the polar angle in laboratory. Using the fission fragments to reconstruct the fission plane, the enhancement of out-plane $R({\rm t/^3He})$ is confirmed in comparison to the in-plane ratios. Transport model simulations reproduce qualitatively the experimental trends, but the quantitative agreement is not achieved. The results demonstrate that a neutron rich neck zone is formed in the reactions. Further studies are called for to understand the clustering and the isospin dynamics related to neck formation