2-(Methyl­sulfan­yl)cyclo­dodeca­none tosyl­hydrazone

The title compound, C20H32N2O2S2, has been synthesized by the reaction of α-methyl­sulfanylcyclo­dodeca­none and p-toluene­sulfonyl­hydrazine. In the crystal structure, the conformation of the non-benzenoid ring is [3333] and the methyl­sulfanyl group is in the α-side exo position. The mol­ecules are linked by inter­molecular N—H⋯S hydrogen bonds

Anthriscifolcine A, a C18-diterpenoid alkaloid

The title compound, C26H39NO7, which was isolated from Delphinium anthriscifolium var. majus, has a lycoctonine carbon skeleton containing four six-membered rings (A, B, D and E) and three five-membered rings (C, F and G). Rings A, B and E adopt chair conformation, while ring D adopts a boat conformation. Rings C and F adopt envelope conformations

Chlorido[N,N′-dibenzyl-N,N′-bis­(pyridin-2-ylmeth­yl)ethane-1,2-diamine]­copper(II) perchlorate methanol monosolvate

In the title solvated mol­ecular salt, [CuCl(C28H30N4)]ClO4·CH3OH, the Cu2+ ion is coordinated by the N,N′,N′′,N′′′-tetra­dentate ligand and a chloride ion, generating a very distorted square-based pyramidal CuN4Cl coordination geometry with the Cl− ion in the basal position. In the crystal, the solvent mol­ecules and anions are linked by weak O—H⋯O hydrogen bonding

SHEARING BEHAVIOR OF STRUCTURAL INSULATED PANEL WALL SHELLED WITH BAMBOO SCRIMBER

In this study, shearing behavior of a structural insulated panel (SIP) wall, which consisted of a Styrofoam core board, shell panel of bamboo scrimber, and frame of Spruce–Pine–Fir dimension lumber, was tested under monotonic and cyclic loads. Results showed that the SIP wall failed at similar positions under two loading modes, although more serious destruction occurred under cyclic than monotonic load. There was a linear relationship between load and displacement at the initial loading stage, which indicated that the wall worked under the elastic state. At a later loading stage, bearing capacity and rigidity decreased as a result of wall slip. Shearing strength under monotonic and cyclic loads was 20.0 and 15.8 kNm-1, respectively, which met the requirement of the standard code for design of timber structures. Energy consumption of the SIP wall covered with bamboo scrimber was 11,556.6 Jm-1

Original Article Downregulation of miR-129 in peripheral blood mononuclear cells is a diagnostic and prognostic biomarker in prostate cancer

Abstract: Objective: The present study was designed to explore the clinical values of microRNA-129 (miR-129) expression in peripheral blood mononuclear cells for prostate cancer patients and the role of miR-129 in the proliferation of prostate cancer. Methods: The peripheral blood mononuclear cells were isolated form blood simple from 98 patients confirmed with prostate cancer and 56 matched healthy volunteers. Reverse transcription quantitative real-time polymerase chain reaction (qRT-PCR) was employed to determine the expression level of miR-129 in peripheral blood mononuclear cells. Cox proportional hazards regression models and Kaplan-Meier analysis were used to evaluate the association of miR-129 expression with clinical and pathological characteristics of prostate cancer patients. The effect of miR-129 on the proliferation of prostate cancer cells in vitro was also determined. Results: Reverse transcription quantitative real-time polymerase chain reaction (qRT-PCR) results showed that the expression of miR-129 was dramatically down-regulated in peripheral blood mononuclear cells for prostate cancer patients in comparison with healthy controls (P<0.05). The decrease in miR-129 expression in peripheral blood mononuclear cells was significantly associated with aggressive clinical pathological features such as histological grade (P=0.010), high preoperative PSA level (P=0.002), pathological stage (P=0.011), high Gleason score (P=0.005), lymph node metastasis (P=0.002), angiolymphatic invasion (P=0.004), biochemical recurrence (P=0.001). The prostate cancer patients with a low miR-129 expression in peripheral blood mononuclear cells had an obviously shorter BCR-free survival compared with high miR-129 expression (P<0.001). The Cox multivariate analysis established that the miR-129 expression may be an independent prognostic factor for biochemical recurrence (BCR)-free survival prostate cancer patients (P=0.000). The results of in vitro CCK-8 assays, as well as proliferating cell nuclear antigen (PCNA) and phosphorylated histone-3 (P-H3) (markers of proliferation) indicated that miR-129 overexpression markedly retarded the proliferation of PC-3 and DU-145 cells. Conclusions: Our results provide the first evidence that the miR129is significantly downregulated in prostate cancer patients and multivariate analysis confirmed that miR-129 is a novel independent prognostic factor for prostate cancer. Overexpression of miR-129 exerts tumor suppressive functions and abrogates prostate cancer growth