Microporous Cobalt(II)–Organic Framework with Open O‑Donor Sites for Effective C₂H₂ Storage and C₂H₂/CO₂ Separation at Room Temperature

The self-assembly of a bifunctional organic ligand with a formate-bridged rod-shaped secondary building unit leads to a new microporous metal–organic framework (MOF). This MOF shows a moderately high C₂H₂ storage capacity (145 cm³/g) and an excellent adsorption selectivity for C₂H₂/CO₂ (11) at room temperature. Furthermore, its discriminatory sorption behavior toward C₂H₂ and CO₂ was probed by computational analysis in detail

Syntheses, Structures, and Sorption Properties of Metal–Organic Frameworks with 1,3,5-Tris(1-imidazolyl)benzene and Tricarboxylate Ligands

Seven new frameworks [Co₃(tib)₂(BPT)₂­(H₂O)₂]­·DMA­·2.5H₂O (<b>1</b>), [Co₃(tib)₂­(BPT)₂­(H₂O)₂]­·DMF·3H₂O (<b>2</b>), [Ni₃(tib)₂­(BPT)₂­(H₂O)₂]­·DMF­·1.5H₂O (<b>3</b>), [Ni₃(tib)₂(BPT)₂­(H₂O)₆]­·2H₂O (<b>4</b>), [Mn­(tib)­(H₂O)₃]­·HBPT·DMF­·2H₂O (<b>5</b>), [Ni₃(tib)₂(BTB)₂­(H₂O)₂]­·14H₂O (<b>6</b>), and [Co₃(tib)₂(BTB)₂]­·2DMF­·6H₂O (<b>7</b>) [tib = 1,3,5-tris­(1-imidazolyl)­benzene, H₃BPT = biphenyl-3,4′,5-tricarboxylic acid, H₃BTB = 4,4′,4″-benzene-1,3,5-triyl-tribenzoic acid, DMA = <i>N</i>,<i>N</i>-dimethylacetamide, DMF = <i>N</i>,<i>N</i>-dimethylformamide] were achieved and structurally characterized. <b>1</b>, <b>2</b>, and <b>3</b> are (3,3,4,4)-connected three-dimensional (3D) frameworks with a point symbol of {8³}₄{8⁵·12}­{8⁶}₂, while <b>4</b>, <b>6</b>, and <b>7</b> are also (3,3,4,4)-connected 3D nets but with different framework structures and topologies. <b>5</b> is a two-dimensional network, which is further joined together by hydrogen bonds to generate a 3D supramolecular framework. Gas, vapor, and dye adsorption properties of the frameworks were examined, and <b>1</b>–<b>7</b> exhibit hysteretic and selective adsorption of CO₂ over N₂. Furthermore, <b>7</b> is a potential adsorbent for removing methylene blue in the aqueous solution

Hybrid framework for rapid evaluation of wind environment around buildings through parametric design, CFD simulation, image processing and machine learning

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Porous Metal–Organic Frameworks with Chelating Multiamine Sites for Selective Adsorption and Chemical Conversion of Carbon Dioxide

A combination of carbon dioxide (CO₂) capture and chemical fixation in a one-step process is attractive for chemists and environmentalists. In this work, by incorporating chelating multiamine sites to enhance the binding affinity toward CO₂, two novel metal–organic frameworks (MOFs) [Zn₂(L)­(2,6-NDC)₂(­H₂O)]­·1.5DMF­·2H₂O (<b>1</b>) and [Cd₂(L)­(2,6-NDC)₂]·1.5DMF·2H₂O (<b>2</b>) (L = <i>N</i>¹-(4-(1<i>H</i>-1,2,4-triazole-1-yl)­benzyl)-<i>N</i>¹-(2-aminoethyl)­ethane-1,2-diamine, 2,6-H₂NDC = 2,6-naphthalenedicarboxylic acid, DMF = <i>N</i>,<i>N</i>-dimethylformamide) were achieved under solvothermal conditions. Both <b>1</b> and <b>2</b> possess high selectivity for adsorption of CO₂ over CH₄ at room temperature under atmospheric pressure. Moreover, <b>1</b> has one-dimensional tubular channels decorated with multiactive sites including NH₂ groups and coordination unsaturated Lewis acid metal sites, leading to efficient catalytic activity for chemical fixation of CO₂ by reaction with epoxides to give cyclic carbonates under mild conditions

Controlled Supramolecular Self-Assembly of Large Nanoparticles in Amphiphilic Brush Block Copolymers

To date the self-assembly of ordered metal nanoparticle (NP)/block copolymer hybrid materials has been limited to NPs with core diameters (<i>D</i>_core) of less than 10 nm, which represents only a very small fraction of NPs with attractive size-dependent physical properties. Here this limitation has been circumvented using amphiphilic brush block copolymers as templates for the self-assembly of ordered, periodic hybrid materials containing large NPs beyond 10 nm. Gold NPs (<i>D</i>_core = 15.8 ± 1.3 nm) bearing poly­(4-vinylphenol) ligands were selectively incorporated within the hydrophilic domains of a phase-separated (polynorbornene-<i>g</i>-polystyrene)-<i>b</i>-(polynorbornene-<i>g</i>-poly­(ethylene oxide)) copolymer via hydrogen bonding between the phenol groups on gold and the PEO side chains of the brush block copolymer. Well-ordered NP arrays with an inverse cylindrical morphology were readily generated through an NP-driven order–order transition of the brush block copolymer

Structural Diversity and Sensing Properties of Metal–Organic Frameworks with Multicarboxylate and 1<i>H</i>‑Imidazol-4-yl-Containing Ligands

Two 1<i>H</i>-imidazol-4-yl-containing ligands 1,3-di­(1<i>H</i>-imidazol-4-yl)­benzene (L¹) and 4,4′-di­(1<i>H</i>-imidazol-4-yl)­biphenyl (L²) were employed to react with corresponding metal salt together with varied carboxylate ligands under hydro- and solvothermal conditions, and six new metal–organic frameworks (MOFs) [Cd­(L¹)­(oba)]­·DMF (<b>1</b>), [Ni₃(L¹)₂­(BPT)₂­(H₂O)₄] (<b>2</b>), [Zn₂(L¹)₂­(HBPT)₂]­·H₂O (<b>3</b>), [Ni­(L¹)­(BPTC)_0.5­(H₂O)₂] (<b>4</b>), [Ni₂(μ₂-O)­(L²)₃­(Hoba)₂­(H₂O)₂] (<b>5</b>), and [Ni₂(L²)₃­(BPTC)­(H₂O)₂]­·6H₂O (<b>6</b>) [H₂oba = 4,4′-oxybis­(benzoic acid), H₃BPT = biphenyl-3,4′,5-tricarboxylic acid, H₄BPTC = biphenyl-3,3′,5,5′-tetracarboxylic acid, DMF = <i>N</i>,<i>N</i>-dimethylformamide] were achieved and structurally characterized. MOFs <b>1</b>, <b>3</b>, <b>4</b>, and <b>5</b> are different two-dimensional networks, which are further joined together by hydrogen bonds to generate three-dimensional (3D) supramolecular frameworks. <b>2</b> is a (4,4)-connected binodal 3D framework with a point symbol of {3·4·5·8³}₄­{3²·8²·9²}, while <b>6</b> is a diamond 3D framework. The results show that coordination geometry of the metal centers and coordination mode of the ligands play important roles in the formation of MOFs with diverse structures. Moreover, luminescent studies showed that <b>1</b> and <b>3</b> represent highly efficient quenching for detecting Fe³⁺ ions and acetone molecules. In addition, <b>6</b> exhibits selectively adsorption of CO₂ over N₂

Proteome Profiling of Mitotic Clonal Expansion during 3T3-L1 Adipocyte Differentiation Using iTRAQ-2DLC-MS/MS

Mitotic clonal expansion (MCE) is one of the important events taking place at the early stage during 3T3-L1 adipocyte differentiation. To investigate the mechanism underlying this process, we carried out a temporal proteomic analysis to profile the dynamic changes in MCE. Using 8-plex-iTRAQ-2DLC-MS/MS analysis, 3152 proteins were quantified during the initial 28 h of 3T3-L1 adipogenesis. Functional analysis was performed on 595 proteins with maximum or minimum quantities at 20 h of adipogenic induction that were potentially involved in MCE, which identified PI3K/AKT/mTOR as the most relevant pathway. Among the 595 proteins, PKM2 (Pyruvate kinase M2), a patterned protein identified as a potential target gene of C/EBPβ in our previous work, was selected for further investigation. Network analysis suggested positive correlations among C/EBPβ, PIN1, and PKM2, which may be related with the PI3K-AKT pathway. Knockdown of PKM2 with siRNA inhibited both MCE and adipocyte differentiation of 3T3-L1 cells. Moreover, PKM2 was down-regulated at both the mRNA level and the protein level upon the knockdown of C/EBPβ. And overexpressed PKM2 can partially restore MCE, although it did not restore terminal adipocyte differentiation, which was inhibited by siC/EBPβ. Thus, PKM2, potentially regulated by C/EBPβ, is involved in MCE during adipocyte differentiation. The dynamic proteome changes quantified here provide a promising basis for revealing molecular mechanism regulating adipogenesis

Eight typical expression patterns including 201 differential proteins during <i>in vitro</i> HCC invasion.

<p>Proteins obtained from the co-culture spheroids at different time points are labeled as Day 0, Day 5, Day 10, and Day 15.</p

Molecular function classification of 201 differentially expressed proteins.

<p>Categorization showed that 32.8% (66/201) of differential proteins were associated with cell adhesion, cytoskeleton regulation, cell motility, ECM remodeling, and angiogenesis.</p

Expression patterns of eight invasion/metastasis-associated genes (MMP2, MMP7, MMP9, CD44, SPP1, CXCR4, CXCL12, and CDH1).

<p>Time course analysis showed remarkable, dynamic alterations in invasion/metastasis gene expression during the development of the HCC invasion model.</p