Evaluation of anti-hyperglycemic activities of phloridzin in diabetic mice

Background: The aim of the study was to investigate the hypoglycemic effects of Phloridzin.Methods and Materials: High fat diet induced diabetic KKAy mice were administered with phloridzin at an oral dose (60 mg/kg/day, ig.) for 10 weeks. A range of parameters, including blood glucose and lipid, serum insulin, glucose tolerance, were tested to evaluate its anti-hyperglycemic effects.Results: Phloridzin decreased water-intake, body weight, FBG, FINS, HOME-IR, Serum leptin, and CRP levels, increased serum adiponectin level in diabetic mice. Phloridzin also improved the oral glucose tolerance test (OGTT) to a certain degree. In addition, phloridzin decreased liver index, and epididymal, perirenal white adipose tissue indexs, increased pancreas index in diabetic mice. At last, phloridzin increased hepatic GK activity and hepatic glycogen level, decreased hepatic PEPCK, G-6-Pase activities in diabetic mice.Conclusions: Phloridzin possessed anti-hyperglycemic activities.Keywords: Diabetes, Phloridzin, FBG, Insulin resistance, Area under curv

An experimental study on biased cognitive processing in accidentally injured patients with different posttraumatic growth levels

Background: Various studies have assessed the negative and/or positive changes in the aftermath of traumatic events. Accidental injuries (such as accidents, injuries, etc.), for its high incidence and disability rate, is easy to cause serious psychological problems and hinder the physical and psychological rehabilitation of the patients.Material and Methods: To explore the characteristics of attention bias in accidentally injured patients with different levels of Posttraumatic growth (PTG), total score of PTG was adopted to screen out 15 high-PTG group and low-PTG group respectively among accidentally injured patients. Dot probe task was used with positive, negative and neutral facial expression pictures as experimental materials. An experimental design of 2 (facial expression: positive and negative)×2 (consistency of probe point and facial expression: consistent and inconsistent)×2 (PTG level: high and low) was employed.Results: Patients with low PTG level had attention bias toward the negative emotional stimuli, and difficulty in distraction from the negative emotional pictures. The value of D and DI were both significantly greater than 0 (p<0.05). Patients with high PTG level did not demonstrate significant attention bias toward positive or negative emotional stimuli. The responding time of patients with high PTG level was significantly shorter than that in patients with low PTG level in the incongruent task (p<0.05).Conclusion: There are different characteristics of implicit cognitive processing in patients with different level of PTG, suggesting the necessity of psychological intervention on the accidentally injured patients.Keywords: Accidentally injured patients; Posttraumatic growth; Attention bias; Dot probe tas

Aqua­(1,10-phenanthroline-κ2 N,N′)bis­(trimethyl­acetato)-κ2 O,O′;κO-cobalt(II)

In the title compound, [Co(C5H9O2)2(C12H8N2)(H2O)], the CoII atom is coordinated in a distorted octahedral environment by three carboxyl O atoms of two trimethyl­acetate ligands, one aqua O atom and two N atoms from 1,10-phen­anthroline. The crystal structure is stabilized by O—H⋯O hydrogen bonds and π–π stacking inter­actions [inter­planar distance between inter­digitating 1,10-phenanthroline ligands = 3.378 (2) Å]

Optical loss compensation in a bulk left-handed metamaterial by the gain in quantum dots

A bulk left-handed metamaterial with fishnet structure is investigated to show the optical loss compensation via surface plasmon amplification, with the assistance of a Gaussian gain in PbS quantum dots. The optical resonance enhancement around 200 THz is confirmed by the retrieval method. By exploring the dependence of propagation loss on the gain coefficient and metamaterial thickness, we verify numerically that the left-handed response can endure a large propagation thickness with ultralow and stable loss under a certain gain coefficient.Comment: 6 pages with 4 figure

Research progress of computer analysis method of SPECT-CT and PET-CT

多模态成像设备的发展是影像学发展的里程碑，继PET-CT后，美国通用电气公司推出了Discovery NM/CT 670，将CT与SPECT有机整合在一起，形成的SPECT/CT新型分子医学影像设备，随着SPECT-CT和PET-CT日益广泛地受到关注和应用，许多关于SPECT-CT和PET-CT图像分析的计算机方法应运而生，越来越受到临床和影像学科的重视。本文就SPECT-CT和PET-CT的计算机分析方法进行了详细的描述。The development of multi-modality imaging devices marks a milestone of medical imaging. Discovery NM/CT 670 was recently launched by Ge Corp in the United States after the development of PET-CT and it integrated CT and SPECT. The newly formed type of molecular imaging equipment of SPECT/CT is getting wide attention along with the application of SPECT-CT and PET-CT so that computer analysis of SPECT-CT and PET-CT image came into being, which was much valued by clinical and imaging studies. The paper described detailed information of SPECT-CT and PET-CT computer analysis