P-wave velocity structure and implications for magmatism and metallogenesis in the southern Altaids: Constraint from wide-angle seismic data along the Altai-Eastern Tianshan traverse

Altaids in the Central Asian Orogenic Belt (CAOB) is one of the world’s largest orogenic belts containing mineral deposits. Together with the Junggar terrain they open an important window to study the Paleozoic tectonic evolution of the CAOB. In this paper, we analyze a 637-km-long wide-angle refraction/reflection seismic profile across the Altai-Eastern Tianshan orogenic belt in the southern Altaids, conducted in September 2018 using 10 large explosive charges fired in drilled holes. We use a traveltime inversion method to reconstruct the lithospheric P-wave velocity structure along the profile. The lithosphere is composed of a 43-55-km-thick crust, a ∼10-km-thick crust-mantle transition layer beneath the Altai Mountain, and a ∼25-km-thick layer of lithospheric mantle. The results clearly reveal: a prominent Moho uplift beneath the Yemaquan Island Arc, two major crustal-scale low-velocity anomalies (LVAs) beneath the Yemaquan Arc and Bogda Mountain, and three high-velocity anomalies (HVAs) near the surface around the Kalatongke, Yemaquan and Kalatage mining areas. We hypothesize that the subduction of the Paleo-Asian Ocean occurred with strong mantle upwelling. We suggest that continued compression of the Paleo-Asian Ocean causes the delamination of lithosphere, as well as asthenospheric material upwelling and magma underplating into the crust. Consistently, Paleozoic mafic-ultramafic rocks and mantle-derived minerals related to gold, copper and nickel deposits, are widely extended in the area. Our results show that the P-wave velocity-depth curves for deeper depths (>30 km) in the southern Altai and Junggar Basin are close to those of the continental arcs and global continent average. Despite powerful Paleozoic subduction activity, orogeny and volcanism strongly modified the lower crust in the region, part of ancient continental crust was still preserved below the southern Altai and Junggar Basin. In addition, the upper part (depth 5–30 km) of the velocity-depth curve for the Junggar Basin is close to that of the Costa Rica volcanic front and the British Columbia accreted terrain, suggesting that Paleozoic orogenic activity has intensively reconstructed the upper-middle crust beneath the Junggar Basin

Numerical computation for the impact of pantograph angles on the near-field and far-field aerodynamic noises of pantographs

Pantographs are an important part of power supply systems of high-speed trains, whose good working performance is a guarantee for the steady power supply and safety operation of high-speed trains. The aerodynamic drag of pantographs will have negative impacts on the running of high-speed trains. In the meanwhile, the disturbance effect of pantographs on airflow will cause large aerodynamic noises when a high-speed train runs at a high speed. Therefore, this paper conducted a numerical simulation for the flow field and aerodynamic noises of pantographs on the symmetrical plane, compared simulation results with experimental one, verified the correctness of the numerical simulation model, and further studied the impact of pantograph angles on radiation noises. When pantographs were working, cylindrical rods which were vertical to the direction of airflows had a more obvious disturbance effect on airflows and caused a larger range of vortex shedding. Shedding vortexes were mainly distributed at the pantograph head, hinge joints between upper and lower arms, and rear bases. Near-field aerodynamic noises on the longitudinal symmetrical plane of pantographs were distributed at the lower arm, middle hinge joints and bases. The maximum appeared at the middle hinge joints. The intensity of vortexes at the middle hinge joints, lower arms and bases when the pantograph angle was 60° was more than that at other pantograph angles. In this case, the near-field aerodynamic noise of pantographs was more than that of other pantograph angles. In addition, radiation noises of observation points of pantographs in all directions presented an obvious linear relationship. The far-field radiation noise of pantographs was gradually decreased with the increased distance from pantographs. In addition, the far-field radiation noises of pantographs on the same vertical plane had the intensity with the same level

Cyanidin-3-O-Glucoside Supplement Improves Sperm Quality and Spermatogenesis in a Mice Model of Ulcerative Colitis

Impaired fertility and low sperm quality are the global health problem with high attention. It has been noted that inflammation may impact fertility by affecting testicular spermatogenesis. Cyanidin-3-O-glucoside is a natural functional pigment with various health benefits. Nevertheless, studies on the mechanism by which C3G protects male reproduction in mice with ulcerative colitis remain scarce. The purpose of this study is to illustrate the potential mechanism of C3G for improving impaired fertility caused by colitis. A DSS-induced colitis model was applied to assess the effects of sperm quality with colitis and the health benefit role of C3G. Results indicated that C3G-treated mice exhibited higher body weight, longer colon length, less crypt damage and focal inflammation infiltration. Being consistent with that, low sperm count, low testis weight, high inflammation levels and abnormal thickness of seminiferous epithelium also observed in the DSS group were significantly recovered upon C3G treatment. These findings suggested that colitis has a close link to impaired fertility. Further analysis found that C3G could significantly suppress the inflammatory mediators in serum. Results conjointly indicated that C3G might improve the impaired fertility of mice with colitis by inhibiting inflammatory cytokines through the blood–testis barrier. C3G could be a promising daily supplement for ameliorating impaired fertility caused by colitis

Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis.

To determine whether polychlorinated biphenyls (PCBs) influence gonadal differentiation in Xenopus laevis, tadpoles were exposed to two Chinese domestic PCBs (PCB3 and PCB5 from Nieuwkoop and Faber stage 46/47 to complete metamorphosis. Gonads were characterized using a dissecting microscope. The control X. laevis had normal ovaries or testes in gross morphology, whereas obviously abnormal testes including ovotestes were found in PCB3- and PCB5-exposed groups. Ovotestes were characterized by morphologic ovaries in the cranial and caudal parts and morphologic testes in the middle part. PCBs did not alter the percentage of females but reduced the percentage of males with morphologically normal testes. The histologic structure of gonads was examined by a series of sections. Morphologically normal and abnormal testes from a few frogs exposed to PCBs were interspersed with oocytes in histologic sections. These testes exhibited looser structure with fewer seminiferous tubes, spermatogonia, and spermatozoa than in controls. The findings suggest that PCB3 and PCB5 have significant feminization effects on gonadal differentiation in X. laevis and that this species is sensitive to endocrine disruption and may be used as a good model to study endocrine disruption

Relationship between adiponectin and testosterone in patients with type 2 diabetes

Introduction: This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes. Materials and methods: Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. Testosterone was determined by the radio-immunoassay, whereas adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). Results: The average serum testosterone did not differ between the diabetes and the control group, but the average adiponectin in the diabetes group was lower (14.6 (14.2-15.0) vs. 24.3 (24.05-24.55) ng/mL, P = 0.001). In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P = 0.009). Univariate correlation analysis showed an inverse weak correlation between adiponectin and testosterone concentrations in male diabetic patients (r = -0.27, P = 0.009). There was no significant correlation between adiponectin and testosterone in female patients (r = -0.05, P = 0.167). Conclusions: We conclude that patients with type 2 diabetes have lower serum adiponectin concen-tration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics