An analysis of the influencing factors of depression in older adults under the home care model

ObjectivesTo explore and analyze the influencing factors of depression in older adults living at home, so as to propose suggestions for improving the quality of older adults living at home.MethodsWe conducted a cross-sectional study on 498 older adults living at home based on questionnaire survey on the general information, daily living ability, health status, and care perception (including self-care, care for cohabitants, and care for non-cohabitants) of older adults living at home, as well as their willingness to help each other, and analyzed the influencing factors of depression among older adults living at home.ResultsThe results showed a willingness to help older adults, self-care, and total activities of daily living (ADL), health status was an influential factor for depression in older adults (p < 0.05).ConclusionIt aims to take targeted measures, such as encouraging older adults at home to actively participate in mutual assistance activities for older adults and care for themselves, so as to prevent and reduce the occurrence of depression in older adults

Covalent Organic Frameworks Based Inorganic/Organic Composite Materials for Photocatalytic Applications

As a rising class of functional porous organic materials with tunable pore structures and flexible chemical environments, covalent organic frameworks (COFs) have demonstrated their tremendous potential in numerous applications, such as adsorption, water purification, heterogeneous catalysis, and organic electronics. In the field of photocatalytic applications, the association of emerging COFs with traditional inorganic catalysts can effectively combine the functionality of COFs with the stability of their inorganic counterparts to construct efficient and stable composite photocatalysts. A rapidly growing new field has been established regarding COFs-based inorganic/organic hybrid photocatalysts, which call for a timely review to summarize recent developments. In this contribution, we revisit this promising composite photocatalysts by emphasizing some recent breakthroughs in synthetic strategies and the enhanced performance in various photocatalytic applications. Simultaneously, the mechanisms of performance improvement are elucidated by analyzing the interactions between the inorganic and organic counterparts. We hope general tactics could be inspired for directing open considerations for the future design of photocatalysts and their practical implementations

Covalent Organic Frameworks Based Inorganic/Organic Composite Materials for Photocatalytic Applications

As a rising class of functional porous organic materials with tunable pore structures and flexible chemical environments, covalent organic frameworks (COFs) have demonstrated their tremendous potential in numerous applications, such as adsorption, water purification, heterogeneous catalysis, and organic electronics. In the field of photocatalytic applications, the association of emerging COFs with traditional inorganic catalysts can effectively combine the functionality of COFs with the stability of their inorganic counterparts to construct efficient and stable composite photocatalysts. A rapidly growing new field has been established regarding COFs-based inorganic/organic hybrid photocatalysts, which call for a timely review to summarize recent developments. In this contribution, we revisit this promising composite photocatalysts by emphasizing some recent breakthroughs in synthetic strategies and the enhanced performance in various photocatalytic applications. Simultaneously, the mechanisms of performance improvement are elucidated by analyzing the interactions between the inorganic and organic counterparts. We hope general tactics could be inspired for directing open considerations for the future design of photocatalysts and their practical implementations

Hepatitis B virus x protein induces epithelial-mesenchymal transition of hepatocellular carcinoma cells by regulating long non-coding RNA

Abstract Background It has been widely accepted that hepatitis B virus X protein (HBx) plays an important role in hepatocellular carcinoma (HCC). This study aimed to explore the function of long non-coding RNAs (lncRNAs) in the epithelial-mesenchymal transition (EMT) induced by HBx. Methods The association between HBx and EMT markers was detected using immunohistochemistry in HCC tissues. The effect of HBx on HCC EMT was assessed through morphological analysis, transwell assay, metastatic in vivo study and detection of EMT markers. LncRNA microarray was used to screen the differently expressed lncRNAs. Small interfering RNA and Western blot were used to analyse the function and mechanism of the locked lncRNA. Results HBx was negatively correlated with the epithelial marker E-cadherin but positively correlated with the mesenchymal marker vimentin in HCC tissues. HBx induced the mesenchymal phenotype and improved the metastatic ability of HCC cells. Meanwhile, HBx down-regulated E-cadherin, whereas it up-regulated vimentin. In HCC cells, HBx altered the expression of 2002 lncRNAs by more than 2-fold. One of them was ZEB2-AS1. Inhibition of ZEB2-AS1 can compensate for the EMT phenotype and reverse the expression of EMT markers regulated by HBx. Additionally, HBx affected the Wnt signalling pathway. Conclusions HBx promotes HCC cell metastasis by inducing EMT, which is at least partly mediated by lncRNAs