Nuclear Receptor Coactivator 2 Promotes Human Breast Cancer Cell Growth by Positively Regulating the MAPK/ERK Pathway

As a member of the p160 steroid receptor coactivator (SRC) family, nuclear receptor coactivator 2 (NCOA2) is known to play essential roles in many physiological and pathological processes, including development, endocrine regulation, and tumorigenesis. However, the biological function of NCOA2 in breast cancer is not fully understood. We found that the copy number of the NCOA2 gene was frequently amplified in four breast cancers datasets, varying from 6 to 10%, and the mRNA levels of NCOA2 were also upregulated in 11% of the sequenced cases/patients (TCGA provisional dataset). Next, we confirmed that NCOA2 silencing significantly suppressed cell proliferation in different breast cancer cell lines, by inducing cell cycle arrest and apoptosis. Mechanistically, whole-transcriptome sequencing (RNA-Seq) analysis showed that NCOA2 depletion leads to downregulation of the MAPK/ERK signaling cascade, possibly via downregulating NCOA2's downstream target RASEF. In conclusion, our results suggest NCOA2 as a potential target of therapeutics against breast cancer

Constraints on Axion-like Particles from a Hard XX-ray Observation of Betelgeuse

We use the first observation of Betelgeuse in hard $X$-rays to perform a novel search for axion-like particles (ALPs). Betelgeuse is not expected to be a standard source of $X$-rays, but light ALPs produced in the stellar core could be converted back into photons in the Galactic magnetic field, producing a detectable flux that peaks in the hard $X$-ray band ($E_\gamma>10\mathrm{\,keV}$). Using a 50 ks observation of Betelgeuse by the $NuSTAR$ satellite telescope, we find no significant excess of events above the expected background. Using models of the regular Galactic magnetic field in the direction of Betelgeuse, we set a 95% C.L. upper limit on the ALP-photon coupling of ${g_{a\gamma}<(0.5-1.8)\times10^{-11}}$ GeV$^{-1}$ (depending on magnetic field model) for ALP masses ${m_{a}<(5.5-3.5) \times10^{-11}}$ eV