Capecitabine, Oxaliplatin, and Irinotecan (XELOXIRI) as Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer

Purpose: This study describes the efficacy and safety of irinotecan and oxaliplatin in combination with capecitabine (XELOXIRI) as a neoadjuvant chemotherapy (NAC) regimen for patients with locally advanced rectal cancer (LARC). Methods: From January 2019 through December 2022, 68 LARC patients treated with XELOXIRI were enrolled in the study. XELOXIRI is administered in a three-week cycle consisting of oxaliplatin 70-110 mg/m2 IV for >120 min on day 1; irinotecan 120-160 mg/m2 IV for 90 min on day 1; and capecitabine 700-1100 mg/m2 orally twice daily for 14 days followed by 7 days off. Sixteen cases were treated with combined radiotherapy, including 8 with long-course radiotherapy and 8 with short-course radiotherapy. The efficacy was evaluated based on pelvic MRI (including TNM stage, CRM, and EMVI status), tumor downstaging rate (to ypT0-2N0M0), pCR rate, R0 resection rate, DFS, and OS, and the safety was assessed according to the incidence of adverse events. Results: Sixty-six people had surgery; the R0 resection rate was 100%, and the rate of anal preservation was 97%. The tumor downstaging rate (to ypT0-2N0M0) in the entire group was 53.0%, and the pCR rate was 12.1%. In the XELOXIRI alone group (N = 47), the tumor downstaging rate was 55.3%, and the pCR rate was 12.8%. In the group receiving radiotherapy (N = 16), the tumor downstaging rate was 56.3%, and the pCR rate was 12.5%. In the whole group, the 3-year DFS was 89.0%, and the 3-year survival rate was 98.5%. The 3-year DFS of the XELOXIRI and XELOXIRI + RT groups was 89.9% and 87.2%, respectively. The most frequent grade 3–4 preoperative toxic reactions were neutropenia (8.8%), diarrhea (4.4%), and anemia (2.9%). All adverse events were tolerable. Conclusions: Neoadjuvant chemotherapy with XELOXIRI appears to be feasible and efficacious for patients with LARC. Although neoadjuvant XELOXIRI alone did not yield our expected pCR rate as NAC for LARC, tumor downstaging, R0 resection, sphincter preservation, local recurrence rate, 3-year DFS, OS, and safety were all satisfactory

Object Detection in Videos with Tubelet Proposal Networks

Object detection in videos has drawn increasing attention recently with the introduction of the large-scale ImageNet VID dataset. Different from object detection in static images, temporal information in videos is vital for object detection. To fully utilize temporal information, state-of-the-art methods are based on spatiotemporal tubelets, which are essentially sequences of associated bounding boxes across time. However, the existing methods have major limitations in generating tubelets in terms of quality and efficiency. Motion-based methods are able to obtain dense tubelets efficiently, but the lengths are generally only several frames, which is not optimal for incorporating long-term temporal information. Appearance-based methods, usually involving generic object tracking, could generate long tubelets, but are usually computationally expensive. In this work, we propose a framework for object detection in videos, which consists of a novel tubelet proposal network to efficiently generate spatiotemporal proposals, and a Long Short-term Memory (LSTM) network that incorporates temporal information from tubelet proposals for achieving high object detection accuracy in videos. Experiments on the large-scale ImageNet VID dataset demonstrate the effectiveness of the proposed framework for object detection in videos.Comment: CVPR 201

Development of a time-to-digital converter ASIC for the upgrade of the ATLAS Monitored Drift Tube detector

The upgrade of the ATLAS muon spectrometer for high-luminosity LHC requires new trigger and readout electronics for the various elements of the detector. We present the design of a time-to-digital converter (TDC) ASIC prototype for the ATLAS Monitored Drift Tube (MDT) detector. The chip was fabricated in a GlobalFoundries 130 nm CMOS technology. Studies indicate that its timing and power consumption characteristics meet the design specifications, with a timing bin variation of 40 ps for all 48 channels with a power consumption of about 6.5 mW per channel.Comment: 9 pages, 12 figure