Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease

Abstract: Monoamine oxidase type B inhibitors act in Parkinson’s disease (PD) via potentiation of dopamine, but may also have neuroprotective effects by reducing oxidative damage. Oxidative damage is also a feature of environmental toxins, including pesticides, that are an established risk factor for PD. Another risk factor is low circulating uric acid (UA), which may relate to UA being the major endogenous antioxidant in the human body. We have undertaken a study of 192 initial admissions for PD in a general hospital neurology department in a partly rural region of Southern China to determine if there is an increased rate of PD in agricultural workers who have a high risk of exposure to pesticides, and how it may relate to deficits in UA. We found a disproportionately high number of agricultural workers admitted with PD (66.7% vs. 54.3% of all neurology admissions) and that PD subjects have a substantial reduction in UA. This is further reduced in agricultural workers and thus may contribute to the increased vulnerability of this group to PD

Unusual cross-shelf transport driven by the changes of wind pattern in a marginal sea

Author Posting. © American Geophysical Union, 2021. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 126(11), (2021): e2021JC017526, https://doi.org/10.1029/2021JC017526.The traditional understanding of the regional circulation in the Northwest Pacific marginal seas is that the Korean Coastal Current flows southward, following the isobaths of 20–50 m. However, an unusual tongue-shaped structure of cold water is observed in satellite SST data in January 2017, indicating a possible offshore spread of cold coastal water into the middle Southern Yellow Sea (SYS). Additional observations, including in situ hydrographic data as well as direct current measurement, also suggest this cross-shelf transport of the Korean Coastal Water in January 2017. Our analysis shows that this flow breaks through the isobaths at ∼37°N, moves southward between 50–75 m, and eventually veers anti-cyclonically at ∼35°N to join the western slope of the SYS. This circulation pattern is further supported by heat budget analysis. Diagnosis of potential vorticity (PV) reveals that the elevated negative PV anomaly imposed by surface wind stress favors this unusual cross-shelf transport. The change of wind pattern, although under a deceasing wind speed condition, plays an important role. This work provides an alternative view of the wintertime circulation pattern and motivates future studies of the variability of the coastal currents over interannual and longer time scales in the SYS.his study was supported by the Shandong Provincial Key Research and Development Program (2019JZZY020713, 2019GHY112057), the National Key Research and Development Program (2016YFC1401406, 2016YFA0600900), the National Natural Science Foundation of China (42076010, 42130403), National Fund Committee-Shandong joint fund (U1706215), the Fundamental Research Funds for the Central Universities (2020042010), and Ocean University of China-Woods Hole Oceanographic Institution Cooperative Research Initiative (24887).2022-05-0

Improving accuracy of protein-protein interaction prediction by considering the converse problem for sequence representation

<p>Abstract</p> <p>Background</p> <p>With the development of genome-sequencing technologies, protein sequences are readily obtained by translating the measured mRNAs. Therefore predicting protein-protein interactions from the sequences is of great demand. The reason lies in the fact that identifying protein-protein interactions is becoming a bottleneck for eventually understanding the functions of proteins, especially for those organisms barely characterized. Although a few methods have been proposed, the converse problem, if the features used extract sufficient and unbiased information from protein sequences, is almost untouched.</p> <p>Results</p> <p>In this study, we interrogate this problem theoretically by an optimization scheme. Motivated by the theoretical investigation, we find novel encoding methods for both protein sequences and protein pairs. Our new methods exploit sufficiently the information of protein sequences and reduce artificial bias and computational cost. Thus, it significantly outperforms the available methods regarding sensitivity, specificity, precision, and recall with cross-validation evaluation and reaches ~80% and ~90% accuracy in <it>Escherichia coli </it>and <it>Saccharomyces cerevisiae </it>respectively. Our findings here hold important implication for other sequence-based prediction tasks because representation of biological sequence is always the first step in computational biology.</p> <p>Conclusions</p> <p>By considering the converse problem, we propose new representation methods for both protein sequences and protein pairs. The results show that our method significantly improves the accuracy of protein-protein interaction predictions.</p

Microwave-Assisted Oxidation of Electrospun Turbostratic Carbon Nanofibers for Tailoring Energy Storage Capabilities

We report the systematic structural manipulation of turbostratic electrospun carbon nanofibers (ECNFs) using a microwave-assisted oxidation process, which is extremely rapid and highly controllable and affords controlled variation of the capacitive energy storage capabilities of ECNFs. We find a nonmonotonic relationship between the oxidation degree of ECNFs and their electrocapacitive performance and present a detailed study on the electronic and crystalline structures of ECNFs to elucidate the origin of this nonmonotonic relation. The ECNFs with an optimized oxidation level show ultrahigh capacitances at high operation rates, exceptional cycling performance, and an excellent energy–power combination. We have identified three key factors required for optimal energy storage performance for turbostratic carbon systems: (i) an abundance of surface oxides, (ii) microstructural integrity, and (iii) an appropriate interlayer spacing

Evaluating the Value of Defensins for Diagnosing Secondary Bacterial Infections in Influenza-Infected Patients

Acute respiratory infections by influenza viruses are commonly causes of severe pneumonia, which can further deteriorate if secondary bacterial infections occur. Although the viral and bacterial agents are quite diverse, defensins, a set of antimicrobial peptides expressed by the host, may provide promising biomarkers that would greatly improve the diagnosis and treatment. We examined the correlations between the gene expression levels of defensins and the viral and bacterial loads in the blood on a longitudinal, precision-medical study of a severe pneumonia patient infected by influenza A H7N9 virus. We found that DEFA5 is positively correlated to the blood load of influenza A H7N9 virus (r = 0.735, p &lt; 0.05, Spearman correlation). DEFB116 and DEFB127 are positively and DEFB108B and DEFB114 are negatively correlated to the bacterial load. Then the diagnostic potential of defensins to discriminate bacterial and viral infections was evaluated on an independent dataset with 61 bacterial pneumonia patients and 39 viral pneumonia patients infected by influenza A viruses and reached 93% accuracy. Expression levels of defensins in the blood may be of important diagnostic values in clinic to indicate viral and bacterial infections

Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy

Vitamin C (VitC) has shown great promise to promote cancer immunotherapy, however, its high hydrophilicity makes it quickly excreted, leading to limited therapeutic efficiency even with frequent high-dose administration. Herein, we provide a pioneering report about the employment of VitC amphiphile self-assembled nanofiber hydrogels for enhanced cancer immunotherapy. Specifically, driven by hydrogen bonding and hydrophobic interactions, the synthesized VitC amphiphile, consisting of a hydrophilic VitC headgroup and a hydrophobic alkyl chain, could self-assemble into an injectable nanofiber hydrogel with self-healing properties. The formed VitC hydrogel not only serves as a reservoir for VitC but also acts as an effective delivery platform for stimulator of interferon genes (STING) agonist-4 (SA). Interestingly, the VitC hydrogel itself exhibits antitumor effects by upregulating genes related to interferon (IFN) signaling, apoptotic signaling and viral recognition and defense. Moreover, the SA-encapsulated VitC hydrogel (SA@VitC hydrogel) synergistically activated the immune system to inhibit the progression of both local and abscopal tumors

Observational and model studies of the circulation in the Gulf of Tonkin, South China Sea

Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 118 (2013): 6495–6510, doi:10.1002/2013JC009455.Moored current measurements were made at one mooring site in the northern Gulf of Tonkin for about 1 year during 1988–1989. Analyses were performed to examine characteristics and variability of tidal and subtidal flows. Rotary spectra showed two peaks at diurnal and semidiurnal periods, with higher diurnal energy. Complex demodulations of diurnal and semidiurnal tidal currents indicated that the tidal current magnitudes varied significantly with seasons: more energetic in the stratified summer than in the vertically well-mixed winter. The observed subtidal currents were highly correlated with the surface wind in winter but not in summer; challenging the conceptual summertime anticyclonic circulation pattern derived using wind-driven homogenous circulation theory. The computed currents from a global ocean model were in good agreement with the observed currents. Similar to the current observations, the model-computed flow patterns were consistent with the conceptual wind-driven circulation pattern in winter but opposite in summer. Process-oriented experiments suggest that the summertime cyclonic circulation in the northern Gulf of Tonkin forms as a result of the combination of stratified wind-driven circulation and tidal-rectified inflow from Qiongzhou Strait. The interaction between the southwest monsoon and buoyancy-driven flow from Hong River can significantly intensify the cyclonic circulation near the surface, but its contribution to the vertically averaged flow of the cyclonic circulation is limited.Y. Ding has been supported by the State Scholarship Fund from the China Scholarship Council. C. Chen serves as chief scientist for the International Center for Marine Studies, Shanghai Ocean University, and his contribution has been supported by the Program of Science and Technology Commission of Shanghai Municipality (09320503700). C. Chen serves as the Zi Jiang Scholar at the State Key Laboratory for Estuarine and Coastal Research (SKLEC) of East China Normal University (ECNU) and Visiting Professor at School of Marine Sciences, Sun Yat-Sen University. C. Chen would like to credit this research to these two universities. Z. Lai’s contribution is supported by NSFC project 41206005 and Sun Yat-Sen University 985 grant 42000–3281301. The development of Global-FVCOM was funded by the US National Science Foundation Office of Polar Programs through grants ARC0712903, ARC0732084, ARC0804029, and ARC1203393.2014-06-0