Cluster-randomized controlled trial of the effects of free glasses on purchase of children's glasses in China:The PRICE (Potentiating Rural Investment in Children's Eyecare) study

Offering free glasses can be important to increase children's wear. We sought to assess whether "Upgrade glasses" could avoid reduced glasses sales when offering free glasses to children in China.In this cluster-randomized, controlled trial, children with uncorrected visual acuity (VA)6/12 in both eyes at 138 randomly-selected primary schools in 9 counties in Guangdong and Yunnan provinces, China, were randomized by school to one of four groups: glasses prescription only (Control); Free Glasses; Free Glasses + offer of $15 Upgrade Glasses; Free Glasses + offer of$30 Upgrade Glasses. Spectacle purchase (main outcome) was assessed 6 months after randomization.Among 10,234 children screened, 882 (8.62%, mean age 10.6 years, 45.5% boys) were eligible and randomized: 257 (29.1%) at 37 schools to Control; 253 (28.7%) at 32 schools to Free Glasses; 187 (21.2%) at 31 schools to Free Glasses + $15 Upgrade; and 185 (21.0$30 Upgrade. Baseline ownership among these children needing glasses was 11.8% (104/882), and 867 (98.3%) children completed follow-up. Glasses purchase was significantly less likely when free glasses were given: Control: 59/250 = 23.6%; Free glasses: 32/252 = 12.7%, P = 0.010. Offering Upgrade Glasses eliminated this difference: Free + $15 Upgrade: 39/183 = 21.3$30 Upgrade: 38/182 = 20.9%, RR 0.91 (0.59, 1.42), P = 0.69.Upgrade glasses can prevent reductions in glasses purchase when free spectacles are provided, providing important program income.ClinicalTrials.gov Identifier: NCT02231606. Registered on 31 August 2014

Study on Dominant Frequency Attenuation of Blasting Vibration for Ultra-Small-Spacing Tunnel

The middle rock pillar in ultra-small-spacing tunnels is significantly narrow, and the stability of the primary support and lining are easily influenced by the blasting vibration wave from an adjacent tunnel. Therefore, understanding the vibration frequency characteristics is essential for the blasting vibration control. Based on the blasting works on a double-track roadway tunnel (Jiuwuji tunnel in Guizhou, China), this study investigates the dominant frequency attenuation in the preceding tunnel with the middle rock pillar spacing ranging from 4.0 m to 9.4 m. The results show that the ranges of the dominant frequency distributions on the primary support and lining are widely within 200 Hz, but there are varieties in their propagation laws. The distribution of the dominant frequencies on the primary support is broader than that on the lining; and the dominant frequencies are concentrated on a specific range when the lining is far from the blast face beside a particular value, which is not present on the primary support. As the presence of cavity and changing medium between the lining and the primary support, it made a significant contribution to the filtering the vibration waves. Furthermore, on the primary support, the high-frequency part of the vibration waves attenuates rapidly with distance, and then, the practical prediction equations describing dominant frequency attenuation were proposed. The comparison on frequency characteristics per delay for the millisecond delay blasting shows that multiple delay sequences blast contributes to a multi-structured amplitude spectrum of blast vibration waves; and the varies of the equivalent explosion sources dimensions and numbers of free surfaces in each blast delay resulting in diverse vibration waveforms. Finally, the dominant frequencies determined by different methods were compared, and the results show a nonlinear relationship between the ZCFs and DFs. The above research conclusion expands the understanding of blasting vibration in tunnel engineering, particularly in the frequency distribution

Research on the Mechanism and Safe Thickness of Karst Tunnel-Induced Water Inrush under the Coupling Action of Blasting Load and Water Pressure

When the drilling and blasting method is used to construct a tunnel through the karst stratum, the coupling effect of the blasting load and the karst water pressure in front of the tunnel face exposes the tunnel face to the risk of water inrush, which threatens the safety of personnel and property. It is very important for the design and construction of related tunnels to study the evolution mechanism of water inrush in karst tunnels and determine the minimum thickness of outburst prevention under blasting. Relying on the Dejiang tunnel Project in Tongren City, this paper adopts the Smoothed Particle Hydrodynamic–Finite Element Method (SPH-FEM) coupling calculation method to study the evolution process of water inrush in karst tunnels under blasting, analyzing the results of water inrush in tunnels under different rock wall thicknesses under blasting. Then, according to the regression of rock wall stress peak data, the analysis determines the minimum outburst prevention thickness of the karst tunnel. The research results show that there is a superposition effect between the blasting stress wave and the gravitational interaction of the karst water itself, and that the Smoothed Particle Hydrodynamic (SPH) particles in the aquifer cause damage and cracks to the rock wall under the coupling action of the blasting load and the karst water pressure, further leading to the expansion of the cracks and the formation of inrush channels. the stress, vibration velocity, and displacement of the unit at the junction of the aquifer and the rock layer show a trend that first decreases, then increases, and then decreases with an increase in the thickness of the rock wall. Based on the actual geological conditions of the Dejiang tunnel project parameters, when the thickness of the rock wall is 3.08 m, the peak stress of the rock formation unit at the junction with the aquifer reaches the maximum value. In order to avoid water inrush during blasting, the minimum outburst prevention thickness should be greater than 3.08 m. Based on the analysis results, a corresponding water inrush prevention plan was formulated on site which effectively guaranteed construction safety and, at the same time, verified the reliability of the analysis results. The relevant research results can provide useful references for similar projects

Research on the Effect of Karst on Foundation Pit Blasting and the Stiffness of Optimal Rock-Breaking Cement Mortar

The existence of karst cavities has an important impact on the safety of foundation pit excavation projects. It is of engineering guiding value to study the influence of karst cavities on the blasting process of foundation pits and how to optimize the stiffness of cement mortar to improve the blasting effect. Based on the karst foundation pit bench blasting project of Shenzhen Dayun Foundation Pit Project, this paper adopts the SPH-FEM coupling calculation method to study the influence of karst cavities, cavity-filling water and cavity-filling silt clay on the rock-blasting process of bench blasting. We analyzed the development process of blasting damage of rock when the stiffness of karst cavity grouting filling changes under the conditions of slightly weathered, moderately weathered and strongly weathered limestone. The calculation results show that the karst cavity near the blasthole changes the direction of the minimum resistance line, which leads to the release of blasting energy; the rock breaking effect is improved when the karst cavity is filled with water medium and clay medium. Under the three limestone conditions, after the karst cavity is pretreated by cement grouting, the increase in the stiffness of the cement mortar makes the rock damage area first increase and then decrease after the karst cavity implosion, and There is a critical cement mortar stiffness that makes the best rock breaking effect. The critical cement stiffness of micro-, medium- and strongly weathered limestone is 2.2%, 6.1% and 27% of the blasted rock mass, respectively, which makes the karst cavity wall stress reach the peak value, and the rock-breaking effect is the best at this time

Characterization of Mechanical Behavior of Ultra-Small Clearance Tunnel Construction in Upper Soil and Lower Rock Composite Strata

It is hard to grasp the deformation law of the surrounding rock and the force characteristics of the support structure during the construction of ultra-small clearance tunnels in upper soil and lower rock composite strata. Based on the ultra-small clearance tunnel in Li Shuping, Tongxin Expressway, Guizhou, this paper adopted a combination of numerical simulation and field monitoring to analyze the influence of different burial depths and soil-rock interface positions on the deformation of the surrounding rock and the internal forces of the support structure of the ultra-small clearance tunnel. The conclusions are: (1) the monitoring data show that the stress in the steel frame of the leading tunnel increases first by the influence of proximity construction, and then decreases and reaches a stable value after the secondary lining is applied, and the stress at the arch waist of the soft soil layer furtherest from the side of the middle rock column is greater than that in the rock layer on the side of the middle rock column; (2) the position of the soil-rock interface has a significant influence on the initial support force of the first tunnel, and the bending moment of the structure increases with the downward movement of the soil-rock interface and the increase in the burial depth; (3) the influence of the soil-rock interface position on the initial support moment of the first tunnel is greater than the influence of proximity construction, a point to which attention should be paid during construction; and (4) when the soil-rock interface is located below the foot of the arch, the deformation of the surrounding rock of the following tunnel will be larger than that of the first tunnel. The results can provide a reference for the design and construction of ultra-small clearance tunnels in upper soil and lower rock composite soft strata and soil strata

Research on the Mechanism and Safe Thickness of Karst Tunnel-Induced Water Inrush under the Coupling Action of Blasting Load and Water Pressure

When the drilling and blasting method is used to construct a tunnel through the karst stratum, the coupling effect of the blasting load and the karst water pressure in front of the tunnel face exposes the tunnel face to the risk of water inrush, which threatens the safety of personnel and property. It is very important for the design and construction of related tunnels to study the evolution mechanism of water inrush in karst tunnels and determine the minimum thickness of outburst prevention under blasting. Relying on the Dejiang tunnel Project in Tongren City, this paper adopts the Smoothed Particle Hydrodynamic–Finite Element Method (SPH-FEM) coupling calculation method to study the evolution process of water inrush in karst tunnels under blasting, analyzing the results of water inrush in tunnels under different rock wall thicknesses under blasting. Then, according to the regression of rock wall stress peak data, the analysis determines the minimum outburst prevention thickness of the karst tunnel. The research results show that there is a superposition effect between the blasting stress wave and the gravitational interaction of the karst water itself, and that the Smoothed Particle Hydrodynamic (SPH) particles in the aquifer cause damage and cracks to the rock wall under the coupling action of the blasting load and the karst water pressure, further leading to the expansion of the cracks and the formation of inrush channels. the stress, vibration velocity, and displacement of the unit at the junction of the aquifer and the rock layer show a trend that first decreases, then increases, and then decreases with an increase in the thickness of the rock wall. Based on the actual geological conditions of the Dejiang tunnel project parameters, when the thickness of the rock wall is 3.08 m, the peak stress of the rock formation unit at the junction with the aquifer reaches the maximum value. In order to avoid water inrush during blasting, the minimum outburst prevention thickness should be greater than 3.08 m. Based on the analysis results, a corresponding water inrush prevention plan was formulated on site which effectively guaranteed construction safety and, at the same time, verified the reliability of the analysis results. The relevant research results can provide useful references for similar projects

Effect of the Sputtering Power on the Structure, Morphology and Magnetic Properties of Fe Films

In this paper, the radio frequency (RF) magnetron sputtering (MS) method was utilized to fabricate multiple sets of the iron film samples under different sputtering powers. With the help of X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM) and vibrating sample magnetometer (VSM), how the sputtering power affected the structure, morphology and magnetic properties of the iron film was studied. XRD results showed that all Fe films have a polycrystalline bcc structure and (110) preferred orientation. According to the Bragg equation calculation, the larger the sputtering power, the larger the average grain size, which is consistent with the results of AFM particle size analysis. The main reason is that the sputtering power affects the grain growth mode. As the sputtering power increases, it gradually changes from a small island-like growth to a thick columnar growth. However, from the surface morphology and height profile, we saw that the iron film deposited under 230 W had the most uniform grain size distribution and the grain size was relatively small. This is why thin films deposited under this condition have the best soft magnetic properties. The saturation magnetization (Ms) reaches 1566 emu/cm3, coercivity (Hc) is 112 Oe, and squareness ratio (Mr/Ms) is 0.40. Therefore, iron film prepared under 230 W has good comprehensive properties (highest Ms, lower Hc and Mr/Ms) that provide an experimental basis for further thin film research work

Experimental Study on the Compression Behavior of Grouted Rock with Bi-Directional Penetrating Crack

Grouting is a common method of reinforcing fractured rock mass. The mechanical property of grouted rock is a major aspect of the reinforcement effect, which depends on the geometry of the crack, the angle (β) between the load direction and the crack, and other factors. Few studies have focused on grouted rock with bi-directional crack which can reflect well the grouting reinforcement in the stratum with developed fractures. To explore the grouting effect on fractured rock mass, uniaxial compression tests were carried out on grouted rock samples with different bidirectional widths (t) and angles cracks. The results showed that: (1) when the β was 30°, the failure mode was sliding along the interface of rock and grout, when the β was 45°, the failure mode was composite failure mode, and when the β was 0°, 60°, or 90°, the failure mode was typical intact rock failure mode; (2) when the β increased from 0° to 90°, the uniaxial compressive strength (UCS) decreased and then increased again; (3) when the β was 30°, the UCS had nothing to do with the grout thickness, and when the β was not 30°, the greater the grout thickness, the greater the compressive strength and the ultimate energy storage capacity. The test results can provide reference for grouting reinforcement construction and design in the underground excavation process

A New Phenylazo-Based Fluorescent Probe for Sensitive Detection of Hypochlorous Acid in Aqueous Solution

In this paper, we designed and synthesized a novel phenylazo-based fluorescent probe (RHN) for the sensing and imaging of hypochlorous acid (HClO) in mitochondria in living cells. In this process, HClO promoted the oxidation of the phenylazo group to generate a free Rhodol fluorophore moiety, which in turn restored strong fluorescence and realized the detection of HClO. As expected, RHN exhibited high selectivity, high sensitivity and rapid response, with detection limits as low as 22 nM (1.155 ng/mL). Importantly, the results of the cell imaging experiments indicated that RHN has the ability to image and sense HClO in mitochondria, which is of great significance for exploration of the specific role of HClO in both the immune system and diseases

Population prevalence of myopia, glasses wear and free glasses acceptance among minority versus Han schoolchildren in China.

AimTo measure myopia, glasses wear and free glasses acceptance among minority and Han children in China.MethodsVisual acuity testing and questionnaires assessing ethnicity, study time, and parental and teacher factors were administered to a population-based sample of 9-12 year old minority and Han children in Yunnan and Guangdong, and their teachers and parents. Refraction was performed on children with uncorrected visual acuity (VA) Main outcome measuresBaseline myopia (uncorrected visual acuity = 1 eye and spherical equivalent refractive power ResultsAmong 10,037 children (mean age 10.6 years, 52.3% boys), 800 (8.0%) were myopic, 4.04% among Yunnan Minority children (OR 0.47, 95%CI 0.33, 0.67, PConclusionMyopia is more common among Han children and in wealthier Guangdong. Baseline differences in glasses wear could be explained by student, teacher and parental factors. Yunnan Minority children were more likely to accept free glasses