1 research outputs found
Arginine-Based Polymer Brush Coatings with Hydrolysis-Triggered Switchable Functionalities from Antimicrobial (Cationic) to Antifouling (Zwitterionic)
Arginine polymer based coatings with
switchable properties were
developed on glass slides (GS) to demonstrate the smart transition
from antimicrobial (cationic) to fouling-resistant (zwitterionic)
surfaces. l-Arginine methyl ester-methacryloylamide (Arg-Est)
and l-arginine-methacryloylamide (Arg-Me) polymer brushes
were grafted from the GS surface via surface-initiated reversible
addition–fragmentation chain-transfer (SI-RAFT) polymerization.
In comparison to the pristine GS and Arg-Me graft polymerized GS (GS-Arg-Me)
surfaces, the Arg-Est polymer brushes-functionalized GS surfaces exhibit
a superior antimicrobial activity. Upon hydrolysis treatment, the
strong bactericidal efficacy switches to good resistance to adsorption
of bovine serum albumin (BSA), the adhesion of Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli, as well as the attachment of Amphora coffeaeformis. In addition, the switchable
coatings are proven to be biocompatible. The stability and durability
of the switchable coatings are also ascertained after exposure to
filtered seawater for 30 days. Therefore, deposition of the proposed
“smart coatings” offers another environmentally friendly
alternative for combating biofouling