ADDP: Anomaly Detection based on Denoising Pretraining

    Acquiring labels in anomaly detection tasks is expensive and challenging. Therefore, as an effective way to improve efficiency, pretraining is widely used in anomaly detection models， which enriches the model's representation capabilities, thereby enhancing both performance and efficiency in anomaly detection. In most pretraining methods, the decoder is typically randomly initialized. Drawing inspiration from the diffusion model, this paper proposed to use denoising as a task to pretrain the decoder in anomaly detection, which is trained to reconstruct the original noise-free input. Denoising requires the model to learn the structure, patterns, and related features of the data, particularly when training samples are limited. This paper explored two approaches on anomaly detection: simultaneous denoising pretraining for encoder and decoder, denoising pretraining for only decoder. Experimental results demonstrate the effectiveness of this method on improving model’s performance. Particularly, when the number of samples is limited, the improvement is more pronounced

Alterations in cellular metabolism under different grades of glioma staging identified based on a multi-omics analysis strategy

Glioma is a type of brain tumor closely related to abnormal cell metabolism. Firstly, multiple combinatorial sequencing studies have revealed this relationship. Genomic studies have identified gene mutations and gene expression disorders related to the development of gliomas, which affect cell metabolic pathways. In addition, transcriptome studies have revealed the genes and regulatory networks that regulate cell metabolism in glioma tissues. Metabonomics studies have shown that the metabolic pathway of glioma cells has changed, indicating their distinct energy and nutritional requirements. This paper focuses on the retrospective analysis of multiple groups combined with sequencing to analyze the changes in various metabolites during metabolism in patients with glioma. Finally, the changes in genes, regulatory networks, and metabolic pathways regulating cell metabolism in patients with glioma under different metabolic conditions were discussed. It is also proposed that multi-group metabolic analysis is expected to better understand the mechanism of abnormal metabolism of gliomas and provide more personalized methods and guidance for early diagnosis, treatment, and prognosis evaluation of gliomas

Residual vibration reduction of high-speed pick-and-place parallel robot using input shaping

Because of their elastic links and joints, high-speed parallel robots for pick-and-place operations inevitably suffer from residual vibrations that significantly degrade their positioning accuracy. An effective approach based on the input shaping technique is presented in this paper for suppressing the residual vibration in these parallel robots. After addressing the design principle of an input shaper for a parallel robot with flexible actuated joints, a robust optimal input shaper is developed by considering the configuration-dependent flexible modes and minimizing the maximum percentage of residual vibration at the end-effector. The input shaper allows a good overall performance to be achieved throughout the entire workspace. Experimental results on a 4-DOF SCARA-type parallel robot show that the residual vibration of the end-effector is dramatically reduced and the dynamic positioning accuracy of the robot significantly improved

Unraveling the mechanisms of NK cell dysfunction in aging and Alzheimer’s disease: insights from GWAS and single-cell transcriptomics

BackgroundAging is an important factor in the development of Alzheimer’s disease (AD). The senescent cells can be recognized and removed by NK cells. However, NK cell function is gradually inactivated with age. Therefore, this study used senescence as an entry point to investigate how NK cells affect AD.MethodsThe study validated the correlation between cognition and aging through a prospective cohort of the National Health and Nutrition Examination Survey database. A cellular trajectory analysis of the aging population was performed using single-cell nuclear transcriptome sequencing data from patients with AD and different ages. The genome-wide association study (GWAS) cohort of AD patients was used as the outcome event, and the expression quantitative trait locus was used as an instrumental variable. Causal associations between genes and AD were analyzed by bidirectional Mendelian randomization (MR) and co-localization. Finally, clinical cohorts were constructed to validate the expression of key genes.ResultsA correlation between cognition and aging was demonstrated using 2,171 older adults over 60 years of age. Gene regulation analysis revealed that most of the highly active transcription factors were concentrated in the NK cell subpopulation of AD. NK cell trajectories were constructed for different age populations. MR and co-localization analyses revealed that CHD6 may be one of the factors influencing AD.ConclusionWe explored different levels of AD and aging from population cohorts, single-cell data, and GWAS cohorts and found that there may be some correlations of NK cells between aging and AD. It also provides some basis for potential causation

Assessment of Bearing Capacity and Stiffness in New Steel Sets Used for Roadway Support in Coal Mines

There is high demand for roadway support in coal mines for the swelling soft rocks. As high strength steel sets can be taken as an effective alternative to control large deformation in this type of rocks, based on an original set, three new sets, including a floor beam set, a roof and floor beams set, and a roof and floor beams and braces set, are proposed in this research. In order to examine the strengths of new sets, four scaled sets of one original set, and three new sets, have been manufactured and tested in loading experiments. Results indicated that three new sets all exhibited higher strength than the original set. In experiments, the roof beam in set plays a significant effect on top arch strengthening, while the floor beam plays significant effect on bottom arch strengthening. The maximum bearing capacity and stiffness of the top arch with roof beam are increased to 1.63 times and 3.06 times of those in the original set, and the maximum bearing capacity and stiffness of the bottom arch with floor beam are increased to 1.44 times and 3.55 times of those in original set. Based on the roof and floor beams, two more braces in the bottom arch also play a significant effect in bottom corners strengthening, but extra braces play little role in top arch strengthening. These new sets provide more choices for roadway support in swelling soft rocks

Dynamic Tensile Strength of Dry and Saturated Hard Coal under Impact Loading

To evaluate the influence of water content on the hard coal dynamic behavior, the dynamic tensile properties of saturated coal Brazilian disk (BD) samples were studied using a split Hopkinson pressure bar system, and dry samples were also tested as a control group. In the range of impact speeds studied, the tensile strength of the saturated coal is lower than that of the dry specimen. A synchronized triggering high-speed camera was used to monitor the deformation and failure process of dry and saturated coal samples, allowing analysis of the failure stages and mechanism of dynamic BD test, the broken mode was classified into three types, which can be classified into unilateral tensile failure, bilateral or multilateral tensile failure, and shear failure. Finally, fragments smaller than 5 mm in diameter were statistically analyzed. There is less debris in range of 0–5.0 mm for the saturated coal sample than for the dry coal. This study provides some information about the dynamic response of the hard coal for the relevant practical engineering

Short-term effects of atmospheric particulate matter on myocardial infarction: a cumulative meta-analysis

Atmospheric particulate matter (PM) is hypothesized to increase the risk of myocardial infarction (MI). However, the epidemiological evidence is inconsistent. We identified 33 studies with more than 4 million MI patients and applied meta-analysis and meta-regression to assess the available evidence. Twenty-five studies presented the effects of the PM level on hospitalization for MI patients, while eight studies showed the effects on mortality. An increase in PM10 was associated with hospitalization and mortality in myocardial infarction patients (RR per 10 μg/m3 = 1.011, 95 % CI 1.006–1.016; RR per 10 μg/m3 = 1.008, 95 % CI 1.004–1.012, respectively); PM2.5 also increased the risk of hospitalization and mortality in MI patients (RR per 10 μg/m3 = 1.024, 95 % CI 1.007–1.041 for hospitalization and RR per 10 μg/m3 = 1.012, 95 % CI 1.010–1.015 for mortality). The results of the cumulative meta-analysis indicated that PM10 and PM2.5 were associated with myocardial infarctionwith the addition of new studies each year. In conclusion, short-term exposure to high PM10 and PM2.5 levels revealed to increase risk of hospitalization and mortality for myocardial infarction. Policy support of pollution control and individual protection was strongly recommended

Does the democratization level of village governance affect perceptions of security and integrity of land rights? -An analysis from the perspective of social network abundance

Improving the land property rights system is an effective way to enhance the rural economy and resist the effects of rural decay caused by rapid urbanization. However, in many developing countries, farmers' perception of the security and integrity of their allocated land rights, which is the core of farmers' decision making, deviates from the forms stipulated by formal land property rights systems. China is no exception in this regard. Based on two household surveys conducted in Jiangsu, Jiangxi, and Liaoning Provinces in China, which cover 2014 and 2018 information, this paper uses an ologit model to explore the impact of the democratization level on farmers' perception of land rights security and integrity and identifies the moderating effect of social network abundance. The results show that a higher democratization level of village governance enhances farmers' perception of the effectiveness of land certificates and the integrity of the bundle of rights but exerts an insignificant impact on farmers’ perception of land reallocation. We also find that social network abundance has a moderating effect. Social network abundance weakens the effect of democratization level on the perception of certificate effectiveness but enhance its effect on the perception of rights integrity. Furthermore, our findings provide a reference for reforming rural land property rights systems and rural governance systems during the process of developing rural revitalization strategies