Deformation Calculating of Electromagnetic Launcher's Rail Subjected to Sinusoidal Magnetic Pressure

The electromagnetic launcher's rail can be modeled as a beam on elastic foundation with simply supported beam by moving load. In this paper, Euler beam theory is applied to build the mechanical model, and the analytical solution of the equation subjected to sinusoidal magnetic pressure is derived in detail, which has successfully avoided the errors which are caused by using the uniform pressure to approximately replace the variable force. Numerical analysis of the influences brought from the elastic coefficient, the damping coefficient, the mass of rail, and the load's velocity on the deformation of beam by the MATLAB software show that the elastic coefficient and the load's velocity have quite obvious effect on the deformation of the beam while the damping coefficient and the mass of rail have not obvious effect on the deformation of the beam

Four novel variants identified in primary hyperoxaluria and genotypic and phenotypic analysis in 21 Chinese patients

Background: Primary hyperoxaluria (PH) is a rare genetic disorder characterized by excessive accumulation of oxalate in plasma and urine, resulting in various phenotypes due to allelic and clinical heterogeneity. This study aimed to analyze the genotype of 21 Chinese patients with primary hyperoxaluria (PH) and explore their correlations between genotype and phenotype.Methods: Combined with clinical phenotypic and genetic analysis, we identified 21 PH patients from highly suspected Chinese patients. The clinical, biochemical, and genetic data of the 21 patients were subsequently reviewed.Results: We reported 21 cases of PH in China, including 12 cases of PH1, 3 cases of PH2 and 6 cases of PH3, and identified 2 novel variants (c.632T > G and c.823_824del) in AGXT gene and 2 novel variants (c.258_272del and c.866-34_866-8del) in GRHPR gene, respectively. A possible PH3 hotspot variant c.769T > G was identified for the first time. In addition, patients with PH1 showed higher levels of creatinine and lower eGFR than those with PH2 and PH3. In PH1, patients with severe variants in both alleles had significantly higher creatinine and lower eGFR than other patients. Delayed diagnosis still existed in some late-onset patients. Of all cases, 6 had reached to end-stage kidney disease (ESKD) at diagnosis with systemic oxalosis. Five patients were on dialysis and three had undergone kidney or liver transplants. Notably, four patients showed a favorable therapeutic response to vitamin B6, and c.823_824dup and c.145A > C may be identified as potentially vitamin B6-sensitive genotypes.Conclusion: In brief, our study identified 4 novel variants and extended the variant spectrum of PH in the Chinese population. The clinical phenotype was characterized by large heterogeneity, which may be determined by genotype and a variety of other factors. We first reported two variants that may be sensitive to vitamin B6 therapy in Chinese population, providing valuable references for clinical treatment. In addition, early screening and prognosis of PH should be given more attention. We propose to establish a large-scale registration system for rare genetic diseases in China and call for more attention on rare kidney genetic diseases

Introduction to Community Service-Learning (SRCL 1000)

Introduction to Community Service-Learning is a general elective open to first to fourth year international and domestic students from a variety of disciplines across campus. Every fall and winter semester each student volunteers at one of 30 local not-for-profit organizations for a full semester. Students are required to complete 24 hours of service as part of their course work. In this poster session, 16 not-for-profit organizations will be represented by 27 SRCL 1000 students. They will demonstrate personal reflections on their service experiences, how their experiences connect to the course work and their organizations, and what they will take back to their own communities after the course is over. Students representing the following Kamloops not-for-profit organizations: Active Care Services: Nolan Fenrich St. John Ambulance: Damilola Abiyo and Ryuki Furuta Overlander Residential Care: Glory Amukamara Ponderosa Lodge: Rahab Kariuki The Kamloops Food Bank: Yu Cao, Surkamal Singh Jhand, Xiangzhong Kong and Ruotong Shi The ReStore – Habitat for Humanity: Dion Maborekhe, Fengyi Yang and Haonan Deng Kamloops Immigrant Services: Dipak Parmar Maple Leaf School: Qian Wang and Mengyao Zhu BC SPCA: Dawei Xu TRU Sustainability Office: Akash Ghosh, Takaya Hirose, Jihoon Kim and Kosuke Masunaga TRU Horticulture: Ols Buta TRU The X Radio: Marie Gabriela Jimenez and MD Majharul Islam Sabuj Beattie School of the Arts: Makoto Iida Gemstone Care Center: Tirth Panchal Chartwell Ridgepointe: Sakina Shikama Sikh Temple: Gurpreet Pua

Deformation Calculating of Electromagnetic Launcher’s Rail Subjected to Exponential Magnetic Pressure

The electromagnetic launcher's rail can be modeled as a beam on elastic foundation with simply supported beam by moving load. In this paper, Euler beam theory is applied to build the mechanical model, and the analytical solution of the equation subjected to sinusoidal magnetic pressure is derived in detail, which has successfully avoided the errors which are caused by using the uniform pressure to approximately replace the variable force. Numerical analysis of the influences brought from the elastic coefficient, the damping coefficient, the mass of rail, and the load's velocity on the deformation of beam by the MATLAB software show that the elastic coefficient and the load's velocity have quite obvious effect on the deformation of the beam while the damping coefficient and the mass of rail have not obvious effect on the deformation of the beam

Innovative Materials for Energy Storage and Conversion

The metal chalcogenides (MCs) for sodium-ion batteries (SIBs) have gained increasing attention owing to their low cost and high theoretical capacity. However, the poor electrochemical stability and slow kinetic behaviors hinder its practical application as anodes for SIBs. Hence, various strategies have been used to solve the above problems, such as dimensions reduction, composition formation, doping functionalization, morphology control, coating encapsulation, electrolyte modification, etc. In this work, the recent progress of MCs as electrodes for SIBs has been comprehensively reviewed. Moreover, the summarization of metal chalcogenides contains the synthesis methods, modification strategies and corresponding basic reaction mechanisms of MCs with layered and non-layered structures. Finally, the challenges, potential solutions and future prospects of metal chalcogenides as SIBs anode materials are also proposed

Novel Fe-based nanocrystalline powder cores with high performance prepared by using industrial materials

The FeSiBPNbCu amorphous magnetic powder with partial crystallization is successfully synthesized using low purity industrial raw materials by gas atomization. The magnetic powder cores (MPCs) are then produced from the mixture of the FeSiBPNbCu powders with 2 wt % epoxy resin as insulation and bonding materials by cold pressing under a compact pressure of 1800 MPa. Evolution of the high-frequency properties for the MPCs with respect to the annealing temperature is systematically studied. The results show that upon annealing at the optimum temperature, the cores exhibit excellent magnetic properties, including high initial permeability of 86 with a high frequency stability up to 10 MHz, high quality factor of 110 at 1 MHz, and low core loss of 1290 mW/cm(3) at 100 kHz for B-m = 0.1 T. It is emphasized that the MPCs prepared by partially crystallized magnetic powders can also achieve lower core losses and higher magnetic permeability, which is of great significance in industrial production

Novel Fe-based nanocrystalline powder cores with high performance prepared by using industrial materials

The FeSiBPNbCu amorphous magnetic powder with partial crystallization is successfully synthesized using low purity industrial raw materials by gas atomization. The magnetic powder cores (MPCs) are then produced from the mixture of the FeSiBPNbCu powders with 2 wt % epoxy resin as insulation and bonding materials by cold pressing under a compact pressure of 1800 MPa. Evolution of the high-frequency properties for the MPCs with respect to the annealing temperature is systematically studied. The results show that upon annealing at the optimum temperature, the cores exhibit excellent magnetic properties, including high initial permeability of 86 with a high frequency stability up to 10 MHz, high quality factor of 110 at 1 MHz, and low core loss of 1290 mW/cm(3) at 100 kHz for B-m = 0.1 T. It is emphasized that the MPCs prepared by partially crystallized magnetic powders can also achieve lower core losses and higher magnetic permeability, which is of great significance in industrial production

Aptamer Technology and Its Applications in Bone Diseases

Aptamers are single-stranded nucleic acids (DNA, short RNA, or other artificial molecules) produced by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology, which can be tightly and specifically combined with desired targets. As a comparable alternative to antibodies, aptamers have many advantages over traditional antibodies such as a strong chemical stability and rapid bulk production. In addition, aptamers can bind targets in various ways, and are not limited like the antigen–antibody combination. Studies have shown that aptamers have tremendous potential to diagnose and treat clinical diseases. However, only a few aptamer-based drugs have been used because of limitations of the aptamers and SELEX technology. To promote the development and applications of aptamers, we present a review of the methods optimizing the SELEX technology and modifying aptamers to boost the selection success rate and improve aptamer characteristics. In addition, we review the application of aptamers to treat bone diseases

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

Hypoxia promotes not only the invasiveness of tumor cells, but also chemoresistance in cancer. Tumor associated macrophages (TAMs) residing at the site of hypoxic region of tumors have been known to cooperate with tumor cells, and promote proliferation and chemoresistance. Therefore, there is an urgent need for new strategies to alleviate tumor hypoxia and enhance chemotherapy response in solid tumors. Herein, we have taken advantage of high accumulation of TAMs in hypoxic regions of tumor and high reactivity of manganese dioxide nanoparticles (MnO₂ NPs) toward hydrogen peroxide (H₂O₂) for the simultaneous production of O₂ and regulation of pH to effectively alleviate tumor hypoxia by targeted delivery of MnO₂ NPs to the hypoxic area. Furthermore, we also utilized the ability of hyaluronic acid (HA) modification in reprogramming anti-inflammatory, pro-tumoral M2 TAMs to pro-inflammatory, antitumor M1 macrophages to further enhance the ability of MnO₂ NPs to lessen tumor hypoxia and modulate chemoresistance. The HA-coated, mannan-conjugated MnO₂ particle (Man-HA-MnO₂) treatment significantly increased tumor oxygenation and down-regulated hypoxia-inducible factor-1 α (HIF-1α) and vascular endothelial growth factor (VEGF) in the tumor. Combination treatment of the tumors with Man-HA-MnO₂ NPs and doxorubicin significantly increased apparent diffusion coefficient (ADC) values of breast tumor, inhibited tumor growth and tumor cell proliferation as compared with chemotherapy alone. In addition, the reaction of Man-HA-MnO₂ NPs toward endogenous H₂O₂ highly enhanced <i>T</i>₁- and <i>T</i>₂-MRI performance for tumor imaging and detection