Overview of the measurements and their meaning in brain functional network.

<p>Overview of brain functional network parameters and their meanings.</p

Statistical tests on the small-world properties of the networks for all the groups after the permutation test.

<p>D_P, the P value of the difference between the normal control and AD group.</p><p>P_P, the permutation P value of the difference between the normal control and AD group.</p><p>Statistical tests on the small-world properties of the networks for all the groups of the permutation test.</p

Surface rendering of the distribution of altered nodes at a connection density of 22%.

<p><b>Colored bars indicate differences in network properties between the NC and AD groups.</b> Blue indicates regions showing an increase in the AD group but not the NCs. Yellow indicates regions showing a decrease in the AD group but not the NCs. In the AD group, the regions showing significant increases in C_p, L_p and E_local are widely distributed across the brain, especially in default mode network regions such as the ACC, PCC, MPFC, HIP and IPL; regions in the temporal lobe such as the STGp/MTGp; and regions in the subcortical structure such as the THA, INS and PUT. The regions showing significant E_global decreases in AD are distributed primarily in the bilateral MTG and motor areas such as the SMA_R and PreCG_R.</p

Change of network parameters as a function of connection density (Cost).

<p>Clustering coefficient (<b>A</b>), shortest path length (<b>B</b>), global efficiency (<b>C</b>) and local efficiency (<b>D</b>) of the AD (green line) and NC (red line) groups as a function of Cost. Clustering coefficient (<b>E</b>), shortest path length (<b>F</b>), global efficiency (<b>G</b>) and local efficiency (<b>H</b>) of the AD ApoE4+ (black line), AD ApoE4− (blue line) and NC ApoE4− (red line) groups as a function of Cost. The error bars correspond to the standard error of the mean. Blue asterisks indicate where the difference between the NC and AD groups is significant (<i>P</i><0.05). Blue circles indicate points where the difference between the AD ApoE4− group and the NC ApoE4− group is significant (<i>P</i><0.05). Blue squares indicate points where the difference between the AD ApoE4+ group and the NC ApoE4− group is significant (<i>P</i><0.05). The difference between the AD ApoE− group and the AD ApoE+ group is not significant at any Cost (<i>P</i>>0.05).</p

Demographic, clinical and neuropsychological data.

a<p>Chi-square was used for gender comparisons.</p>b<p>Two samples two sides <i>t</i>-test was used for age and neuropsychological tests comparisons between AD and NC.</p>c<p>One-way ANOVA was performed for age and neuropsychological tests comparisons.</p>d<p>Two samples two sides <i>t</i>-test was used for age and neuropsychological tests comparisons between ApoE− and ApoE+ in AD group.</p><p>MMSE, Mini-Mental State Examination, DRS, Dementia Rating Scale.</p><p>Gray background means the detail statistical of the subject divided by using ApoE genotype.</p><p>Demographic, clinical and neuropsychological data in normal control patients (NCs) and Alzheimer's disease patients (AD).</p

Surface rendering of the distribution of nodes differing between the AD ApoE4+ and ApoE4− groups.

<p>Colored bars indicate differences in network properties between the two groups. Blue indicates regions showing an increase in the AD ApoE4+ group. Yellow indicates regions showing a decrease in the AD ApoE4+ group. The ApoE4− group displayed higher C_p, higher E_local, and longer L_p in the temporal, frontal and medial prefrontal cortexes, and lower E_global in the frontal cortex.</p

Statistical tests on the topological properties of the networks for all the groups after the permutation test.

<p>D_P, the P value of the difference between the normal control and AD group.</p><p>P_P, the permutation P value of the difference between the normal control and AD group.</p><p>Statistical tests on the topological properties of the networks for all the groups of the permutation test.</p