Jet-dominated quiescent states in black hole X-ray binaries: the case of V404 Cyg

The dynamical and radiative properties of the quiescent state (X-ray luminosity $<10^{34}\ {\rm erg s^{-1} cm^{-2}}$) of black hole X-ray transients (BHXTs) remains unclear, mainly because of low-luminosity and poor data quantity. We demonstrate that, the simultaneous multi-wavelength (including radio, optical, ultraviolet and X-ray bands) spectrum of V404 Cyg in its bright quiescent state can be well described by the radiation from the companion star and more importantly, the compact jet. Neither the outer thin disc nor the inner hot accretion flow is important in the total spectrum. Together with several additional recent findings, i.e. the power-law X-ray spectrum and the constant X-ray spectral shape (or constant photon index) in contrast to the dramatic change in the X-ray luminosity, we argue the quiescent state spectrum of BHXTs is actually jet-dominated. Observational features consistent with this jet model are also discussed as supporting evidences.Comment: accepted for the publication in MNRAS Letters, 5 pages, 2 figure

Transductive Multi-label Zero-shot Learning

Zero-shot learning has received increasing interest as a means to alleviate the often prohibitive expense of annotating training data for large scale recognition problems. These methods have achieved great success via learning intermediate semantic representations in the form of attributes and more recently, semantic word vectors. However, they have thus far been constrained to the single-label case, in contrast to the growing popularity and importance of more realistic multi-label data. In this paper, for the first time, we investigate and formalise a general framework for multi-label zero-shot learning, addressing the unique challenge therein: how to exploit multi-label correlation at test time with no training data for those classes? In particular, we propose (1) a multi-output deep regression model to project an image into a semantic word space, which explicitly exploits the correlations in the intermediate semantic layer of word vectors; (2) a novel zero-shot learning algorithm for multi-label data that exploits the unique compositionality property of semantic word vector representations; and (3) a transductive learning strategy to enable the regression model learned from seen classes to generalise well to unseen classes. Our zero-shot learning experiments on a number of standard multi-label datasets demonstrate that our method outperforms a variety of baselines.Comment: 12 pages, 6 figures, Accepted to BMVC 2014 (oral

Learning Task Informed Abstractions

Current model-based reinforcement learning methods struggle when operating from complex visual scenes due to their inability to prioritize task-relevant features. To mitigate this problem, we propose learning Task Informed Abstractions (TIA) that explicitly separates reward-correlated visual features from distractors. For learning TIA, we introduce the formalism of Task Informed MDP (TiMDP) that is realized by training two models that learn visual features via cooperative reconstruction, but one model is adversarially dissociated from the reward signal. Empirical evaluation shows that TIA leads to significant performance gains over state-of-the-art methods on many visual control tasks where natural and unconstrained visual distractions pose a formidable challenge.Comment: 8 pages, 12 figure

High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts.

Key pointsPatients with diabetes show a blunted cardiac inotropic response to β-adrenergic stimulation despite normal cardiac contractile reserve. Acute insulin stimulation impairs β-adrenergically induced contractile function in isolated cardiomyocytes and Langendorff-perfused hearts. In this study, we aimed to examine the potential effects of hyperinsulinaemia associated with high-fat diet (HFD) feeding on the cardiac β2 -adrenergic receptor signalling and the impacts on cardiac contractile function. We showed that 8 weeks of HFD feeding leads to reductions in cardiac functional reserve in response to β-adrenergic stimulation without significant alteration of cardiac structure and function, which is associated with significant changes in β2 -adrenergic receptor phosphorylation at protein kinase A and G-protein receptor kinase sites in the myocardium. The results suggest that clinical intervention might be applied to subjects in early diabetes without cardiac symptoms to prevent further cardiac complications.AbstractPatients with diabetes display reduced exercise capability and impaired cardiac contractile reserve in response to adrenergic stimulation. We have recently uncovered an insulin receptor and adrenergic receptor signal network in the heart. The aim of this study was to understand the impacts of high-fat diet (HFD) on the insulin-adrenergic receptor signal network in hearts. After 8 weeks of HFD feeding, mice exhibited diabetes, with elevated insulin and glucose concentrations associated with body weight gain. Mice fed an HFD had normal cardiac structure and function. However, the HFD-fed mice displayed a significant elevation of phosphorylation of the β2 -adrenergic receptor (β2 AR) at both the protein kinase&nbsp;A site serine 261/262 and the G-protein-coupled receptor kinase site serine 355/356 and impaired adrenergic reserve when compared with mice fed on normal chow. Isolated myocytes from HFD-fed mice also displayed a reduced contractile response to adrenergic stimulation when compared with those of control mice fed normal chow. Genetic deletion of the β2 AR led to a normalized adrenergic response and preserved cardiac contractile reserve in HFD-fed mice. Together, these data indicate that HFD promotes phosphorylation of the β2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes