Diaqua­{6,6′-dimeth­oxy-2,2′-[ethane-1,2-diylbis(nitrilo­methyl­idyne)]diphenolato-κ2 O,N,N′,O′}manganese(III) perchlorate 18-crown-6 hemisolvate monohydrate

In the cation of the title compound, [Mn(C18H18N2O4)(H2O)2]ClO4·0.5C12H24O6·H2O, the MnIII ion is coordinated by two water O atoms, and two O atoms and two N atoms from the tetradentate 6,6′-dimeth­oxy-2,2′-[ethane-1,2-diylbis(nitrilo­methyl­idyne)]di­phenolate ligand, completing a distorted octa­hedral geometry. One O atom of the 18-crown-6-ether is disordered over two positions with occupancies of 0.70 (2) and 0.30 (2)

Di-μ-chlorido-bis­[chlorido(N,N-di­methyl­ethylenediamine-κ2 N,N′)zinc(II)]

The centrosymmetric dinuclear title compound, [Zn2Cl4(C4H12N2)2], is isostructural with its previously reported CuII analogue [Phelps, Goodman & Hodgson (1976 ▶). Inorg. Chem. 15, 2266–2270]. In the title compound, each of the ZnII ions is coordinated by two N atoms from a chelating N,N-dimethyl­ethylenediamine ligand, two bridging Cl atoms and one terminal Cl atom. The coordination environment is distorted square-pyramidal. The Zn—Cl bond distances of the two bridging Cl atoms are distinctly different: the equatorial Cl atom exbibits a Zn—Cl distance of 2.318 (1) Å and the axial Cl atom exbibits a Zn—Cl distance of 2.747 (2) Å, which is significantly longer. The mol­ecule can thus be seen as a dimer of two nearly square-planar monomeric units which are related to each other by an inversion center located in the middle of the dimer. Within one monomeric unit, the Zn atom, the two N atoms and the two Cl atoms are almost coplanar, with a mean deviation of only 0.05 (1) Å from the associated least-squares plane. The Zn⋯Zn distance within the dimer is 3.472 (3) Å. N—H⋯Cl and C—H⋯Cl hydrogen-bond inter­actions connect neighboring mol­ecules with each other

Tris(1,10-phenanthroline-κ2 N,N′)iron(II) μ-oxido-bis[trichloridoferrate(III)] ethanol hemisolvate

The title compound, [Fe(C12H8N2)3][Fe2Cl6O]·0.5CH3CH2OH, consists of one [Fe(phen)3]2+ cation (phen = 1,10-phen­anthroline), one [Fe2Cl6O]2− anion and one half-mol­ecule of ethanol. In the cation, the FeII atom is coordinated by six N atoms from three phen ligands in a distorted octa­hedral geometry. In the bent anion, two FeIII atoms are connected by a bridging oxide O atom [bridging angle = 160.6 (4)°], and each FeIII atom is also coordinated by three Cl atoms, completing a distorted tetra­hedral geometry

{6,6′-Dimeth­oxy-2,2′-[4-bromo-o-phenyl­enebis(nitrilo­methyl­idyne)]diphenolato}nickel(II) methanol solvate

In the title compound, [Ni(C22H17BrN2O4)]·CH3OH, the NiII ion is in a slightly distorted square-planar geometry involving an N2O2 atom set of the tetra­dentate Schiff base ligand. The asymmetric unit contains one nickel complex and one methanol solvent mol­ecule. The dihedral angle between the aromatic ring planes of the central aromatic ring and other two aromatic rings are 10.8 (3) and 6.0 (2)°. The crystal structure is stabilized by inter­molecular C—H⋯O and C—H⋯Br and by intra­molecular O—H⋯O hydrogen bonds

Quantum Spectra of Hydrogen Atoms in Various Magnetic Fields with the Closed Orbit Theory

The quantum spectra of hydrogen atoms in various magnetic fields have been calculated with the closed orbit theory. The magnitude of the magnetic field decreases from 5.96 T to 0.56T with a step of 0.6T. We demonstrate schematically that the closed orbits disappear with the decrease of the magnitude of the magnetic field when the corresponding finite resolution of experiment is fixed. This may give us a good way to control the shape and the number of the closed orbits in the system, and thus to control where a peak should exist in the Fourier transformation of the quantum spectra.Comment: 4 page

PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells

<p>Abstract</p> <p>Background</p> <p>PCBP1 (or alpha CP1 or hnRNP E1), a member of the PCBP family, is widely expressed in many human tissues and involved in regulation of transcription, transportation process, and function of RNA molecules. However, the role of PCBP1 in CD44 variants splicing still remains elusive.</p> <p>Results</p> <p>We found that enforced PCBP1 expression inhibited CD44 variants expression including v3, v5, v6, v8, and v10 in HepG2 cells, and knockdown of endogenous PCBP1 induced these variants splicing. Invasion assay suggested that PCBP1 played a negative role in tumor invasion and re-expression of v6 partly reversed the inhibition effect by PCBP1. A correlation of PCBP1 down-regulation and v6 up-regulation was detected in primary HCC tissues.</p> <p>Conclusions</p> <p>We first characterized PCBP1 as a negative regulator of CD44 variants splicing in HepG2 cells, and loss of PCBP1 in human hepatic tumor contributes to the formation of a metastatic phenotype.</p