1,1′-[o-Phenyl­enebis(nitrilo­methyl­idyne)]di-2-naphthol ethanol hemisolvate

The asymmetric unit of the title compound, C28H20N2O2·0.5C2H5OH, contains two independent mol­ecules of 1,1′-[o-phenyl­enebis(nitrilo­methyl­idyne)]di-2-naphthol, denoted A and B, and one ethanol solvent mol­ecule. The hydr­oxy groups are involved in intra­molecular O—H⋯N hydrogen bonds influencing the mol­ecular conformations, which are slightly different in mol­ecules A and B, where the two bicyclic systems form dihedral angles of 51.93 (9) and 58.52 (9)°, respectively. In the crystal structure, a number of short inter­molecular C⋯C contacts with distances of less than 3.5 Å suggest the existence of π–π inter­actions, which contribute to the stability of the crystal packing

An Hα Imaging Survey of All (Ultra)luminous Infrared Galaxies at Decl. ≥ -30 in the GOALS Sample

This paper presents the result of Hα imaging for luminous and ultraluminous infrared galaxies. It is a complete subsample of the Great Observatories All-sky LIRG Survey (GOALS) with decl. ≥ -30 , and consists of 148 galaxies with log(L IR/L ) ≥ 11.0. All the Hα images were carried out using the 2.16 m telescope at the Xinglong Station of the National Astronomy Observatories, Chinese Academy of Sciences (NAOC), during the year from 2006 to 2009. We obtained the pure Hα luminosity for each galaxy and corrected the luminosity for [N ii] emission, filter transmission, and extinction. We also classified these galaxies based on their morphology and interaction. We found that the distribution of star-forming regions in these galaxies is related to this classification. As the merging process advanced, these galaxies tended to have a more compact distribution of star-forming regions, higher L IR, and warmer IR-color (f 60/f 100). These results imply that the degree of dynamical disturbance plays an important role in determining the distribution of a star-forming region

Novel Polysaccharide H-1-2 from Pseudostellaria Heterophylla Alleviates Type 2 Diabetes Mellitus

Background/Aims: To investigate the potential therapeutic effect of novel polysaccharide H-1-2 from pseudostellaria heterophylla against type 2 Diabetes Mellitus (T2DM) and elucidate the underling molecular mechanisms. Methods: Relative expression of HIF1α and Sirt1 in T2DM patients was determined via real-time PCR. The direct binding of HIF1α on Sirt1 promoter was validated by ChIP assay. The inhibitory regulation of Sirt1 by HIF1α was analyzed using luciferase reporter assay. The endogenous protein of HIF1α and Sirt1 in response to H-1-2 treatment was quantified by western blotting. The blood glucose, secreted insulin and serous lipid profiles were measured with ELISA kits. Results: We consolidated that HIF1α and Sirt1 was dysregulated in T2DM patients and subjected to H-1-2 modulation. H-1-2 significantly inhibited hypoxia and up-regulated Sirt1 expression in EndoC-βH1 cells. Accordingly, H-1-2 enhanced glucose-stimulation insulin secretion and improved blood glucose and lipid profiles in T2DM cells, and elevated the glucose and insulin tolerance simultaneously. Furthermore, we demonstrated that H-1-2 alleviated T2DM via inhibition of hypoxia and up-regulation of Sirt1 in isolated pancreatic β-cells from T2DM rats. Conclusion: Our data unambiguously demonstrated H-1-2 administration alleviated T2DM by enhancing Sirt1 expression through inhibition of hypoxia

Susceptibility of kuruma shrimp to the infection with Decapod iridescent virus 1

Infection with Decapod iridescent virus 1 (iDIV1), an important emerging disease of shrimps and crabs, has been included in the Quarterly Aquatic Animal Disease Report (QAAD) by the Network of Aquaculture Centres in Asia-Pacific (NACA) and listed by the World Organization for Animal Health (WOAH). China has classified iDIV1 as a Class II animal pandemic disease. In the present study, to determine the susceptibility of Penaeus japonicus to Decapod iridescent virus 1 (DIV1), healthy kuruma shrimp were artificially infected with DIV1 (isolate SHIV 20141215) by per os (the pathway that mimics natural transmission) and intramuscular injection (invasive pathway). The infected P. japonicus showed clinical signs such as anorexia, retardation, evident reddish body, swollen and whitish lymphoid organs, and mortalities of almost 100%. Real-time PCR showed that all the challenged individuals by per os or intramuscular routes were DIV1-positive with an average virus load between 10(9.09 ± 0.58) and 10(8.94 ± 0.45) copies/μg-DNA, respectively. Histological examination revealed karyopyknosis, and eosinophilic inclusions and minute basophilic stains were combined in lymphoid organs, hematopoietic tissue and gills of diseased individuals. In addition, lymphoid organs showed disorganization of the tubule matrix. In situ DIG-labeling loop-mediated isothermal amplification (ISDL) also demonstrated the presence of DIV1 signals existed in lymphoid organs, hemopoietic tissue, gills, epithelial tissue, hepatopancreas and muscle. Ultrathin sections examined using transmission electron microscopy (TEM) revealed the presence of DIV1 virions, the virogenic stroma, and the nucleocapsid production process in infected cells. In addition, pathogen surveillance of cultured samples showed that the DIV1 detection rate of farmed P. japonicus samples from five coastal provinces in China was 5.3% (9/157) in 2022. The results mentioned above support that P. japonicus is a newly confirmed susceptible host for DIV1, enhancing the pathogen ecological understanding of pathogens and giving more support for developing DIV1 preventive and control strategies

Rectal cancer patients with downstaging after neoadjuvant chemoradiotherapy and radical resection do not benefit from adjuvant chemotherapy

Background: Whether adjuvant chemotherapy is beneficial for rectal cancer patients who respond well to neoadjuvant chemoradiotherapy (NCRT) and undergo radical resection is controversial. This study aimed to assess the effect of adjuvant chemotherapy on the oncological outcomes of ypT0-2N0 rectal cancer patients after NCRT and radical resection, and identify the prognostic factors. Methods: The clinical and pathological data of rectal cancer patients with ypT0-2N0 who underwent NCRT and radical resection between January, 2010 and June, 2018 were collected and retrospectively analyzed. The oncological outcomes of the chemotherapy (chemo) group and the non-chemotherapy (non-chemo) group were compared. Multivariate analysis, using a Cox proportional hazard model, was performed to identify independent predictors of oncological outcome. Results: Of the 121 rectal cancer patients enrolled, 90 patients received postoperative adjuvant chemotherapy with no fewer than 3 cycles (the chemo group), and the other 31 patients with fewer than 3 cycles (the non-chemo group). There was no significant difference in the 5-year disease-free survival (DFS) or overall survival (OS) rates between the two groups (DFS: 79.1% vs. 82.9%, P=0.442; OS: 87.5% vs. 78.2%, P=0.667). cT4 is an independent risk factor for OS (HR =4.227, 95% CI: 1.128-15.838, P=0.02) and DFS (HR =4.878, 95% CI: 1.752-13.578). Preoperative consolidation chemotherapy with Capeox or FOLFOX after NCRT significantly improved the DFS rate (HR =0.212, 95% CI: 0.058-0.776, P=0.019). Conclusions: Rectal cancer patients with ypT0-2N0 who underwent NCRT and radical resection did not benefit significantly from postoperative adjuvant chemotherapy. For these patients, cT4 was an independent risk factor for OS and DFS. Preoperative consolidation chemotherapy with Capeox or FOLFOX after NCRT can significantly improve DFS