Relationship between Adiponectin Gene Polymorphisms and Late-Onset Alzheimer's Disease.

In recent years, researchers have found that adiponectin (ANP) plays an important role in the pathogenesis of Alzheimer's disease (AD), and low serum concentrations of ANP are associated with AD. Higher plasma ANP level have a protective effect against the development of cognitive decline, suggesting that ANP may affect AD onset. Meanwhile, accumulating evidence supports the crucial role of ANP in the pathogenesis of AD. To study the relationship between ANP gene polymorphisms (rs266729, -11377C>G and rs1501299, G276T) and late-onset AD (LOAD), we carried out a case-control study that included 201 LOAD patients and 257 healthy control subjects. Statistically significant differences were detected in the genotype and allelotype frequency distributions of rs266729 and rs1501299 between the LOAD group and the control group, with a noticeable increase in the G and T allelotype frequency distributions in the LOAD group (P 0.05) between the LOAD group and control group, whereas the CG and GT haplotypes were significantly different (P < 0.05), suggesting a negative correlation between the CG haplotype and LOAD onset (OR = 0.74, 95% CI = 0.57-0.96, P = 0.022), and a positive correlation between the GT haplotype and LOAD onset (OR = 2.29, 95% CI = 1.42-3.68, P = 0.005). Therefore, we speculated that the rs266729 and rs1501299 of ANP gene polymorphisms and the GT and CG haplotypes were associated with LOAD

Comparison of clinical characteristics between the AD and control groups.

<p>* <i>P</i> < 0.05. ≤ primary school, illiterate or educated to primary school level;> primary school, educated above primary school level; BMI, body mass index;TC, total cholesterol; TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein.</p><p>Comparison of clinical characteristics between the AD and control groups.</p

Spectrometric peak chart of rs266729.

<p>(A) <i>ANP</i> gene rs266729 (-11377C>G) CC genotype. (B) <i>ANP</i> gene rs266729 (-11377C>G) CG genotype. (C) <i>ANP</i> gene rs266729 (-11377C>G) GG genotype.</p

Correlation analysis between <i>ANP</i> gene haplotypes and AD.

<p>* <i>P</i> < 0.05 indicates statistically significant differences.</p><p>Correlation analysis between <i>ANP</i> gene haplotypes and AD.</p

Spectrometric peak chart of rs1501299.

<p>(A) <i>ANP</i> gene rs1501299 (G276T) GG genotype. (B) <i>ANP</i> gene rs1501299 (G276T) GT genotype. (C) <i>ANP</i> gene rs1501299 (G276T) TT genotype.</p