3 research outputs found
CuX Dual Catalysis: Construction of Oxazolo[2,3‑<i>b</i>][1,3]oxazines via a Tandem CuAAC/Ring Cleavage/[4+2+3] Annulation Reaction
CuX as a simple dual catalyst strategy that promotes
the tandem
transformations of fused oxazolo[2,3-b][1,3]oxazines
has been developed. Copper catalyzed terminal ynones, sulfonyl azides,
and nitriles for the CuAAC/ring cleavage/[4+2] annulation reaction,
while the halogen catalyzed ring cleavage and [2+3] annulation of
oxiranes to form the final fused products. This study provides a four-component,
one-pot strategy for synthesizing complex fused heterocycles from
simple ingredients and expands the application of CuAAC in organic
synthesis
CuX Dual Catalysis: Construction of Oxazolo[2,3‑<i>b</i>][1,3]oxazines via a Tandem CuAAC/Ring Cleavage/[4+2+3] Annulation Reaction
CuX as a simple dual catalyst strategy that promotes
the tandem
transformations of fused oxazolo[2,3-b][1,3]oxazines
has been developed. Copper catalyzed terminal ynones, sulfonyl azides,
and nitriles for the CuAAC/ring cleavage/[4+2] annulation reaction,
while the halogen catalyzed ring cleavage and [2+3] annulation of
oxiranes to form the final fused products. This study provides a four-component,
one-pot strategy for synthesizing complex fused heterocycles from
simple ingredients and expands the application of CuAAC in organic
synthesis
Palladium-Catalyzed Tandem Reaction of Three Aryl Iodides Involving Triple C–H Activation
A novel palladium-catalyzed tandem
reaction of <i>N</i>-(2-iodoaryl)Âacrylamides with two aryl
iodides for the synthesis
of spirooxindole has been achieved. The reaction underwent the process
of triple C–H activation and four C–C bond formations
based on the double trapping of transient spirocyclic palladacycles
which are obtained through remote C–H activation