The Effect of Explicit Structure Encoding of Deep Neural Networks for Symbolic Music Generation

With recent breakthroughs in artificial neural networks, deep generative models have become one of the leading techniques for computational creativity. Despite very promising progress on image and short sequence generation, symbolic music generation remains a challenging problem since the structure of compositions are usually complicated. In this study, we attempt to solve the melody generation problem constrained by the given chord progression. This music meta-creation problem can also be incorporated into a plan recognition system with user inputs and predictive structural outputs. In particular, we explore the effect of explicit architectural encoding of musical structure via comparing two sequential generative models: LSTM (a type of RNN) and WaveNet (dilated temporal-CNN). As far as we know, this is the first study of applying WaveNet to symbolic music generation, as well as the first systematic comparison between temporal-CNN and RNN for music generation. We conduct a survey for evaluation in our generations and implemented Variable Markov Oracle in music pattern discovery. Experimental results show that to encode structure more explicitly using a stack of dilated convolution layers improved the performance significantly, and a global encoding of underlying chord progression into the generation procedure gains even more.Comment: 8 pages, 13 figure

Electrochemical performance of Mo2C@PtRu synthesized by electrochemical deposition method on methanol oxidation

The electrodeposition of Platinum and Ruthenium nanoparticles into Molybdenum carbide/ glassy carbon electrodes and their catalytic activity for the oxidatlon of methanol are described. These Mo2C@PtRu electrodes exhibit good activity with respect to the catalytic oxidation of methanol. The electrodes exhibited excellent long term stabilty in the acidic methanol solutions

Quantifying immediate price impact of trades based on the kk-shell decomposition of stock trading networks

Traders in a stock market exchange stock shares and form a stock trading network. Trades at different positions of the stock trading network may contain different information. We construct stock trading networks based on the limit order book data and classify traders into $k$ classes using the $k$-shell decomposition method. We investigate the influences of trading behaviors on the price impact by comparing a closed national market (A-shares) with an international market (B-shares), individuals and institutions, partially filled and filled trades, buyer-initiated and seller-initiated trades, and trades at different positions of a trading network. Institutional traders professionally use some trading strategies to reduce the price impact and individuals at the same positions in the trading network have a higher price impact than institutions. We also find that trades in the core have higher price impacts than those in the peripheral shell.Comment: 6 pages including 3 figures and 1 tabl

A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications.

RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a novel strategy to achieve consistent high-yield biosynthesis of chimeric RNAs carrying various small RNAs (e.g. miRNAs, siRNAs and RNA aptamers), which was based upon an optimal noncoding RNA scaffold (OnRS) derived from tRNA fusion pre-miR-34a (tRNA/mir-34a). Multi-milligrams of chimeric RNAs (e.g. OnRS/miR-124, OnRS/GFP-siRNA, OnRS/Neg (scrambled RNA) and OnRS/MGA (malachite green aptamer)) were readily obtained from 1 l bacterial culture. Deep sequencing analyses revealed that mature miR-124 and target GFP-siRNA were selectively released from chimeric RNAs in human cells. Consequently, OnRS/miR-124 was active in suppressing miR-124 target gene expression and controlling cellular processes, and OnRS/GFP-siRNA was effective in knocking down GFP mRNA levels and fluorescent intensity in ES-2/GFP cells and GFP-transgenic mice. Furthermore, the OnRS/MGA sensor offered a specific strong fluorescence upon binding MG, which was utilized as label-free substrate to accurately determine serum RNase activities in pancreatic cancer patients. These results demonstrate that OnRS-based bioengineering is a common, robust and versatile strategy to assemble various types of small RNAs for broad applications