Conjunction cFDR: Pleiotropic loci in FNK BMD and RA.

<p>Conjunction cFDR: Pleiotropic loci in FNK BMD and RA.</p

Identification of novel genetic loci for osteoporosis and/or rheumatoid arthritis using cFDR approach - Fig 2

<p>A) ‘‘Conditional Manhattan plot” of conditional –log₁₀ FDR values for FNK BMD given RA (FNK BMD|RA); B) “Conditional Manhattan plot” of conditional –log₁₀ FDR values for RA given FNK BMD(RA|FNK BMD); C) “Conjunction Manhattan plot” of conjunction –log₁₀ FDR values for FNK BMD and RA. SNPs with conditional -log₁₀ FDR>1.3 (i.e. FDR<0.05) are shown above the red line.</p

Conditional QQ plots.

<p>Conditional QQ plots of nominal versus empirical –log₁₀ p-values for (A) FNK BMD as a function of significance of the association with RA, and (B) RA as a function of significance of the association with FNK BMD. The diagonal line represents the null hypothesis.</p

Functional term enrichment analysis.

<p>Functional term enrichment analysis.</p