205 research outputs found
Diagnosis and management of vaginal leiomyoma: A case report and literature review
Objectives: Leiomyomas are benign mesenchymal tumors that consist of smooth muscle cells and varying amounts of fibrous stroma. Uterine leiomyomas are the most common, affecting 20% to 30% of reproductive-age women, but vaginal leiomyomas are rare. Treatments gradually diversify with increased awareness of vaginal leiomyoma, but transvaginal fibroid resection remains the commonly used scheme.
Case report: Herein, we present the case of a 50-year-old asymptomatic woman who had a mass in the left anterior wall of the vagina discovered by gynecological examination and ultrasound. We used oxytocin diluent injection during surgery to create a water pad in the tissue space and then performed a transvaginal myomectomy. There was little or negligible intraoperative bleeding and no peripheral tissue injury, early or late postoperative complications, incision dehiscence, and no surgical site infection.
Conclusions: Transvaginal ultrasonography is the preferred examination for vaginal leiomyomas, and transvaginal myomectomy is the classic treatment method. The formation of a water pad with oxytocin dilution can effectively reduce intraoperative bleeding and shorten surgery time
Experimental observation of highly anisotropic elastic properties of two-dimensional black arsenic
Anisotropic two-dimensional layered materials with low-symmetric lattices
have attracted increasing attention due to their unique orientation-dependent
mechanical properties. Black arsenic (b-As), with the puckered structure,
exhibits extreme in-plane anisotropy in optical, electrical and thermal
properties. However, experimental research on mechanical properties of b-As is
very rare, although theoretical calculations predicted the exotic elastic
properties of b-As, such as anisotropic Young's modulus and negative Poisson's
ratio. Herein, experimental observations on highly anisotropic elastic
properties of b-As were demonstrated using our developed in situ tensile
straining setup based on the effective microelectromechanical system. The
cyclic and repeatable load-displacement curves proved that Young's modulus
along zigzag direction was ~1.6 times greater than that along armchair
direction, while the anisotropic ratio of ultimate strain reached ~2.5,
attributed to hinge structure in armchair direction. This study could provide
significant insights to design novel anisotropic materials and explore their
potential applications in nanomechanics and nanodevices.Comment: 19 pages, 5 figure
Highly Anisotropic Elastic Properties of Suspended Black Arsenic Nanoribbons
Anisotropy, as an exotic degree of freedom, enables us to discover the
emergent two-dimensional (2D) layered nanomaterials with low in-plane symmetry
and to explore their outstanding properties and promising applications. 2D
black arsenic (b-As) with puckered structure has garnered increasing attention
these years owing to its extreme anisotropy with respect to the electrical,
thermal, and optical properties. However, the investigation on mechanical
properties of 2D b-As is still lacking, despite much effort on theoretical
simulations. Herein, we report the highly anisotropic elastic properties of
suspended b-As nanoribbons via atomic force microscope-based nanoindentation.
It was found that the extracted Young's modulus of b-As nanoribbons exhibits
remarkable anisotropy, which approximates to 72.2 +- 5.4 and 44.3 +- 1.4 GPa
along zigzag and armchair directions, respectively. The anisotropic ratio
reaches up to ~ 1.6. We expect that these results could lay a solid foundation
for the potential applications of 2D anisotropic nanomaterials in the
next-generation nanomechanics and optoelectronics.Comment: 17 pages, 5 figure
Sensory Features in Affective Analysis: A Study Based on Neural Network Models
This study proposes an ensemble model to incorporate sensory features
of lexical items in English from external resources into neural affective analysis
frameworks. This allows the models to take the combined effects of bi-directional
feeling between the sensory lexicon and the writer to infer human affective
knowledge. We evaluate our model on two affective analysis tasks. The ensemble
model exhibits the best accuracy and the results with 1% F1-score improvement
over the baseline LSTM model in the sentiment analysis task. The performance
shows that perceptual information can contribute to the performance of sentiment
classification tasks significantly. This study also provides a support for the
linguistic finding that correlations exist between sensory features and sentiments
in the language
Intralayer Negative Poisson's Ratio in Two-Dimensional Black Arsenic by Strain Engineering
Negative Poisson's ratio as the anomalous characteristic generally exists in
artificial architectures, such as re-entrant and honeycomb structures. The
structures with negative Poisson's ratio have attracted intensive attention due
to their unique auxetic effect and many promising applications in shear
resistant and energy absorption fields. However, experimental observation of
negative Poisson's ratio in natural materials barely happened, although various
two-dimensional layered materials are predicted in theory. Herein, we report
the anisotropic Raman response and the intrinsic intralayer negative Poisson's
ratio of two-dimensional natural black arsenic (b-As) via strain engineering
strategy. The results were evident by the detailed Raman spectrum of b-As under
uniaxial strain together with density functional theory calculations. It is
found that b-As was softer along the armchair than zigzag direction. The
anisotropic mechanical features and van der Waals interactions play essential
roles in strain-dependent Raman shifts and negative Poisson's ratio in the
natural b-As along zigzag direction. This work may shed a light on the
mechanical properties and potential applications of two-dimensional puckered
materials.Comment: 23 pages, 4 figure
Epitaxial growth of high quality thin films by pulsed laser deposition
Non-collinear antiferromagnet Weyl semimetal have attracted great
research interest recently. Although large anomalous Hall effect, anomalous
Nernst effect and magneto-optical effect have been observed in , most
studies are based on single crystals. So far, it is still challenging to grow
high quality epitaxial thin films with transport and optical
properties comparable to their single crystal counterparts. Here, we report the
structure, magneto-optical and transport properties of epitaxial thin
films fabricated by pulsed laser deposition (PLD). Highly oriented
(0001) and (110) epitaxial films are successfully
growth on single crystalline and MgO substrates. Large anomalous Hall
effect (AHE) up to =3.02 , and
longitudinal magneto-optical Kerr effect (LMOKE) with = 38.1 mdeg at
633 nm wavelength are measured at 300 K temperature, which are comparable to
single crystals. Our work demonstrates that high quality
epitaxial thin films can be fabricated by PLD, paving the way for future device
applications
p53/p21 Pathway Involved in Mediating Cellular Senescence of Bone Marrow-Derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients
Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior and are involved in the pathogenesis of SLE. Numerous studies have shown that activation of the p53/p21 pathway inhibits the proliferation of BM-MSCs. The aim of this study was to determine whether p53/p21 pathway is involved in regulating the aging of BM-MSCs from SLE patients and the underlying mechanisms. We further confirmed that BM-MSCs from SLE patients showed characteristics of senescence. The expressions of p53 and p21 were significantly increased, whereas levels of Cyclin E, cyclin-dependent kinase-2, and phosphorylation of retinoblastoma protein were decreased in the BM-MSCs from SLE patients and knockdown of p21 expression reversed the senescent features of BM-MSCs from SLE patients. Our results demonstrated that p53/p21 pathway played an important role in the senescence process of BM-MSCs from SLE
Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1
SummaryWe report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct cell-cell contact, ECs secrete factors that promoted the CSC phenotype in CRC cells via Notch activation. In human CRC specimens, CD133 and Notch intracellular domain-positive CRC cells colocalized in perivascular regions. An EC-derived, soluble form of Jagged-1, via ADAM17 proteolytic activity, led to Notch activation in CRC cells in a paracrine manner; these effects were blocked by immunodepletion of Jagged-1 in EC-conditioned medium or blockade of ADAM17 activity. Collectively, ECs play an active role in promoting Notch signaling and the CSC phenotype by secreting soluble Jagged-1
An experimental study on cervix cancer with combination of HSV-TK/GCV suicide gene therapy system and 60Co radiotherapy
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