Magnetic Modulation and Cation-Exchange in a Series of Isostructural (4,8)-Connected Metal–Organic Frameworks with Butterfly-like [M₄(OH)₂(RCO₂)₈] Building Units

A series of isostructural metal-carboxylate frameworks [Me₂NH₂]­[M₂(bptc)­(μ₃-OH)­(H₂O)₂] (H₄bptc = 3,3′,4,4′-biphenyltetracarboxylic acid, M = Co, Co_0.83Ni_0.17, Co_0.55Ni_0.45, Co_0.13Ni_0.87, and Ni for <b>1</b>–<b>5</b>, respectively) have been synthesized, which feature (4,8)-connected <i><b>scu</b></i> topological anionic frameworks constructed by a butterfly-like [M₄(OH)₂(RCO₂)₈] cluster and have three-dimensional (3D) channels filled by in situ generated [Me₂NH₂]⁺ cations. Flame atomic absorption spectroscopy (FAAS), scanning electron microscope energy-disperse X-ray spectroscopy (SEM-EDS), infrared spectroscopy (IR), Raman spectroscopy, and powder X-ray diffraction (PXRD) measurements reveal that <b>1</b> can selectively exchange alkali metal cations. Magnetic properties display that monometallic <b>1</b> and <b>5</b> are characteristic of a antiferromagnet and a ferromagnet, respectively. Incorporation of Co and Ni into the system produced heterometallic compounds <b>2</b>, <b>3</b>, and <b>4</b>. Compound <b>2</b> with a very low ratio of Ni to Co shows antiferromagnetic behavior similar to <b>1</b>, while compounds <b>3</b> and <b>4</b> with a large ratio of Ni to Co are characteristic of ferrimagnetic-like behavior. This work demonstrates that magnetic tuning from antiferromagnetic, ferrimagnetic-like, to ferromagnetic behaviors can be achieved by heterometallic substitution in isostructural magnetic frameworks

Magnetic Modulation and Cation-Exchange in a Series of Isostructural (4,8)-Connected Metal–Organic Frameworks with Butterfly-like [M₄(OH)₂(RCO₂)₈] Building Units

A series of isostructural metal-carboxylate frameworks [Me₂NH₂]­[M₂(bptc)­(μ₃-OH)­(H₂O)₂] (H₄bptc = 3,3′,4,4′-biphenyltetracarboxylic acid, M = Co, Co_0.83Ni_0.17, Co_0.55Ni_0.45, Co_0.13Ni_0.87, and Ni for <b>1</b>–<b>5</b>, respectively) have been synthesized, which feature (4,8)-connected <i><b>scu</b></i> topological anionic frameworks constructed by a butterfly-like [M₄(OH)₂(RCO₂)₈] cluster and have three-dimensional (3D) channels filled by in situ generated [Me₂NH₂]⁺ cations. Flame atomic absorption spectroscopy (FAAS), scanning electron microscope energy-disperse X-ray spectroscopy (SEM-EDS), infrared spectroscopy (IR), Raman spectroscopy, and powder X-ray diffraction (PXRD) measurements reveal that <b>1</b> can selectively exchange alkali metal cations. Magnetic properties display that monometallic <b>1</b> and <b>5</b> are characteristic of a antiferromagnet and a ferromagnet, respectively. Incorporation of Co and Ni into the system produced heterometallic compounds <b>2</b>, <b>3</b>, and <b>4</b>. Compound <b>2</b> with a very low ratio of Ni to Co shows antiferromagnetic behavior similar to <b>1</b>, while compounds <b>3</b> and <b>4</b> with a large ratio of Ni to Co are characteristic of ferrimagnetic-like behavior. This work demonstrates that magnetic tuning from antiferromagnetic, ferrimagnetic-like, to ferromagnetic behaviors can be achieved by heterometallic substitution in isostructural magnetic frameworks

High-Grade Tumor Budding Stratifies Early-Stage Cervical Cancer with Recurrence Risk

<div><p>Objectives</p><p>This study investigated prognostic significance of tumor budding in early-stage cervical cancer (ESCC) following radical surgery and its contribution to improve the stratification of patients with recurrence risk.</p><p>Methods</p><p>The archival medical records and H&E-stained slides of 643 patients with IA2-IIA stage cervical cancer who underwent radical surgery were retrospectively reviewed. Clinicopathological parameters were noted, and tumor buds were counted using immunohistochemistry for each case. The prognostic significance of tumor budding was analyzed. Prediction models that comprised tumor budding were established, and the performance was compared between the novel models and classic criteria via log-rank test and receiver operating characteristic analysis.</p><p>Results</p><p>Tumors with high-grade tumor budding (HTB) exhibited a substantially increased risk of recurrence (hazard ratio = 4.287, <i>P</i> < 0.001). Nine predictive models for recurrence were established, in which HTB was combined with recognized risk factors. The model using of at least two risk factors of HTB, tumor size ≥ 4 cm, deep stromal invasion of outer 1/3, and lymphovascular space invasion to stratify patients with an intermediate risk was most predictive of recurrence compared with the classic criteria.</p><p>Conclusions</p><p>Tumor budding is an independent, unfavorable, prognostic factor for ESCC patients following radical surgery and holds promise for improved recurrence risk stratification.</p></div

Receive operating characteristic (ROC) curves for the accuracy of disease recurrence.

<p>A, ROC curve aiding the selection of the cut-off value for low-grade budding (LTB) and high-grade budding (HTB). A value of 5 buds was selected because of its high sensitivity and specificity. B, ROC curves using various clinicopathological risk factors. HTB exhibited higher areas under the curve (AUC = 0.727) than the other classic clinicopathological risk factors. Abbreviations: OUT 1/3, stromal invasion of the outer 1/3; 2CM, tumor size ≥ 2 cm; 4CM, tumor size ≥ 4 cm.</p

Participant flow and the frequency of tumor budding.

<p>A, patient selection flow chart. B, patient distribution by the intensity of tumor buds, counted in a microscopic field of 0.95 mm².</p

Correlations between tumor budding and clinicopathological characteristics (N = 643).

<p>Correlations between tumor budding and clinicopathological characteristics (N = 643).</p

Variation in the rates of SOC mineralization during the whole incubation at different incubation temperatures (5, 15, 25, and 35°C) in EBF (a), CF (b), SDF (c), and AM (d).

<p>Inserted panels e for EBF, f for CF, g for SDF, and h for AM show the cumulative percent of SOC mineralized during the whole incubation. Different letters indicate significant differences in the cumulative percent of SOC mineralized among different incubation temperatures at <i>P</i><0.05. Values are Mean±SE. EBF, evergreen broadleaf forest; CF, coniferous forest; SDF, sub-alpine dwarf forest; AM, alpine meadow.</p

Meta-analysis of XRCC1 Arg399Gln polymorphism in childhood ALL. a Additive model, b Dominant model.

<p>Meta-analysis of XRCC1 Arg399Gln polymorphism in childhood ALL. a Additive model, b Dominant model.</p

General characteristics of studies included in the meta-analysis.

a<p>HWE Hardy–Weinberg equilibrium.</p>b<p>Genotype distributions of Arg194Trp in the controls were significantly deviated from HWE 399 Arg399Gln, 194 Arg194Trp, 280 Arg280His.</p

Results of the meta-analysis on XRCC1 polymorphisms and childhood ALL risk.

<p>OR Odds ratio; 95% CI 95% confidence interval.</p><p>a:minor allele; A:major allele.</p