Intermolecular C–H Quaternary Alkylation of Aniline Derivatives Induced by Visible-Light Photoredox Catalysis

The intermolecular direct C–H alkylation of aniline derivatives with α-bromo ketones to build a quaternary carbon center was reported with a visible-light catalysis procedure. The reaction covers a variety of functional groups with good to excellent yields. A regioselectivity favoring the <i>ortho</i> position for the amine group was observed and investigated with Fukui indices and spectral methods

Intermolecular C–H Quaternary Alkylation of Aniline Derivatives Induced by Visible-Light Photoredox Catalysis

The intermolecular direct C–H alkylation of aniline derivatives with α-bromo ketones to build a quaternary carbon center was reported with a visible-light catalysis procedure. The reaction covers a variety of functional groups with good to excellent yields. A regioselectivity favoring the <i>ortho</i> position for the amine group was observed and investigated with Fukui indices and spectral methods

Univariate analysis of tumor grade and T and N status.

<p>A.Five-year OS of the well/moderately differentiated group was better than that of the poorly/undifferentiated group (30.5% vs. 22.4%, P = 0.046); B. Five-year OS of the T1–2 group was better than that of the T3–4 group (32.2% vs. 20.3%, P = 0.031); C. Five-year OS of the lymph node negative group was better than that of the lymph node positive group (33.9% vs. 9.5%, P = 0.000).</p

Kaplan-Meier estimates of the OS and DFS according to the rate of membrane expression to whole cellular expression (M/C) in ESCC patients.

<p>A. Kaplan-Meier curves illustrating the OS of the high M/C ratio group versus the low M/C ratio group. Five-year OS of the high ratio M/C group was significantly higher compared to that of the low M/C ratio group (41.0% vs. 6.7%, P = 0.000); B. Kaplan-Meier curves illustrating the DFS of the high M/C ratio group versus the low M/C ratio group. Five-year DFS of the high M/C ratio group were significantly higher compared to those of the low M/C ratio group (44.1% vs. 24.9%, P = 0.007).</p

Relationship between p120ctn localization and histological and clinical variables.

<p>Relationship between p120ctn localization and histological and clinical variables.</p

Schematic diagrams of rs2295418 and rs360057 locations within the translated region of <i>Lefty-2</i> and <i>Lefty -1</i> genes and transforming growth factor-β-like domain of the proteins.

<p>A: Lefty-1; B: Lefty-2.</p

SNP rs2295418, rs360057 within Lefty-2 and Lefty-1 associated with the risk of congenital heart diseases in Chinese populations.

<p>a: The minimum expected count;</p><p>b: Not assuming the null hypothesis;</p><p>c: Using the asymptotic standard error assuming the null hypothesis;</p><p>d: Based on normal approximation.</p

Immunostaining of P120ctn in ESCC and esophageal epithelial tissues.

<p>A. Immunohistochemical staining showed p120^ctn expressed in tumor cells (the lower left part of the figure) and normal cells (the upper right part of the figure); B. P120^ctn was mainly located in tumor cell cytoplasm. C.P120^ctn was mainly located in tumor cell cytomembrane.</p

The genotype and allele frequency of SNP rs2295418, rs360057 and g.G169A in 230 Chinese Han CHD patients and 263 non-CHD controls.

<p>The genotype and allele frequency of SNP rs2295418, rs360057 and g.G169A in 230 Chinese Han CHD patients and 263 non-CHD controls.</p

PCR primers used for Lefty sequence analysis.

<p>PCR primers used for Lefty sequence analysis.</p