30,334 research outputs found
Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1
In a screen designed to discover suppressors of mitotic catastrophe, we identified the Xenopus ortholog of 53BP1 (X53BP1), a BRCT protein previously identified in humans through its ability to bind the p53 tumor suppressor. X53BP1 transcripts are highly expressed in ovaries, and the protein interacts with Xp53 throughout the cell cycle in embryonic extracts. However, no interaction between X53BP1 and Xp53 can be detected in somatic cells, suggesting that the association between the two proteins may be developmentally regulated. X53BP1 is modified via phosphorylation in a DNA damage-dependent manner that correlates with the dispersal of X53BP1 into multiple foci throughout the nucleus in somatic cells. Thus, X53BP1 can be classified as a novel participant in the DNA damage response pathway. We demonstrate that X53BP1 and its human ortholog can serve as good substrates in vitro as well as in vivo for the ATM kinase. Collectively, our results reveal that 53BP1 plays an important role in the checkpoint response to DNA damage, possibly in collaboration with ATM
The Physical Connections Among IR QSOs, PG QSOs and Narrow-Line Seyfert 1 Galaxies
We study the properties of infrared-selected QSOs (IR QSOs),
optically-selected QSOs (PG QSOs) and Narrow Line Seyfert 1 galaxies (NLS1s).
We compare their properties from the infrared to the optical and examine
various correlations among the black hole mass, accretion rate, star formation
rate and optical and infrared luminosities. We find that the infrared excess in
IR QSOs is mostly in the far infrared, and their infrared spectral indices
suggest that the excess emission is from low temperature dust heated by
starbursts rather than AGNs. The infrared excess is therefore a useful
criterion to separate the relative contributions of starbursts and AGNs. We
further find a tight correlation between the star formation rate and the
accretion rate of central AGNs for IR QSOs. The ratio of the star formation
rate and the accretion rate is about several hundred for IR QSOs, but decreases
with the central black hole mass. This shows that the tight correlation between
the stellar mass and the central black hole mass is preserved in massive
starbursts during violent mergers. We suggest that the higher Eddington ratios
of NLS1s and IR QSOs imply that they are in the early stage of evolution toward
classical Seyfert 1's and QSOs, respectively.Comment: 32 pages, 6 figures, accepted by Ap
An collider based on proton-driven plasma wakefield acceleration
Recent simulations have shown that a high-energy proton bunch can excite
strong plasma wakefields and accelerate a bunch of electrons to the energy
frontier in a single stage of acceleration. This scheme could lead to a future
collider using the LHC for the proton beam and a compact electron
accelerator of length 170 m, producing electrons of energy up to 100 GeV. The
parameters of such a collider are discussed as well as conceptual layouts
within the CERN accelerator complex. The physics of plasma wakefield
acceleration will also be introduced, with the AWAKE experiment, a proof of
principle demonstration of proton-driven plasma wakefield acceleration, briefly
reviewed, as well as the physics possibilities of such an collider.Comment: 6 pages, 2 figures, to appear in the proceedings of the DIS 2014
Workshop, 28 April - 2 May, Warsaw, Polan
Collider design issues based on proton-driven plasma wakefield acceleration
Recent simulations have shown that a high-energy proton bunch can excite
strong plasma wakefields and accelerate a bunch of electrons to the energy
frontier in a single stage of acceleration. It therefore paves the way towards
a compact future collider design using the proton beams from existing
high-energy proton machines, e.g. Tevatron or the LHC. This paper addresses
some key issues in designing a compact electron-positron linear collider and an
electron-proton collider based on existing CERN accelerator infrastructure
Luminous Infrared Galaxies in the Local Universe
We study the morphology and star formation properties of 159 local luminous
infrared galaxy (LIRG) using multi-color images from Data Release 2 (DR2) of
the Sloan Digital Sky Survey (SDSS). The LIRGs are selected from a
cross-correlation analysis between the IRAS survey and SDSS. They are all
brighter than 15.9 mag in the r-band and below redshift ~ 0.1, and so can be
reliably classified morphologically. We find that the fractions of
interacting/merging and spiral galaxies are ~ 48% and ~ 40% respectively. Our
results complement and confirm the decline (increase) in the fraction of spiral
(interacting/merging) galaxies from z ~1 to z ~ 0.1, as found by Melbourne, Koo
& Le Floc'h (2005). About 75% of spiral galaxies in the local LIRGs are barred,
indicating that bars may play an important role in triggering star formation
rates > 20 M_{sun}/yr in the local universe. Compared with high redshift LIRGs,
local LIRGs have lower specific star formation rates, smaller cold gas
fractions and a narrower range of stellar masses. Local LIRGs appear to be
either merging galaxies forming intermediate mass ellipticals or spiral
galaxies undergoing high star formation activities regulated by bars.Comment: 22 pages, 5 figures, accepted for publication in ApJ, title changed,
typos corrected,major revisions following referee's comments,updated
reference
Probing for cosmological parameters with LAMOST measurement
In this paper we study the sensitivity of the Large Sky Area Multi-Object
Fiber Spectroscopic Telescope (LAMOST) project to the determination of
cosmological parameters, employing the Monte Carlo Markov Chains (MCMC) method.
For comparison, we first analyze the constraints on cosmological parameters
from current observational data, including WMAP, SDSS and SN Ia. We then
simulate the 3D matter power spectrum data expected from LAMOST, together with
the simulated CMB data for PLANCK and the SN Ia from 5-year Supernovae Legacy
Survey (SNLS). With the simulated data, we investigate the future improvement
on cosmological parameter constraints, emphasizing the role of LAMOST. Our
results show the potential of LAMOST in probing for the cosmological
parameters, especially in constraining the equation-of-state (EoS) of the dark
energy and the neutrino mass.Comment: 7 pages and 3 figures. Replaced with version accepted for publication
in JCA
Magneto-frictional Modeling Of Coronal Nonlinear Force-free Fields. I. Testing With Analytic Solutions
We report our implementation of the magneto-frictional method in the Message Passing Interface Adaptive Mesh Refinement Versatile Advection Code (MPI-AMRVAC). The method aims at applications where local adaptive mesh refinement (AMR) is essential to make follow-up dynamical modeling affordable. We quantify its performance in both domain-decomposed uniform grids and block-adaptive AMR computations, using all frequently employed force-free, divergence-free, and other vector comparison metrics. As test cases, we revisit the semi-analytic solution of Low and Lou in both Cartesian and spherical geometries, along with the topologically challenging Titov-Démoulin model. We compare different combinations of spatial and temporal discretizations, and find that the fourth-order central difference with a local Lax-Friedrichs dissipation term in a single-step marching scheme is an optimal combination. The initial condition is provided by the potential field, which is the potential field source surface model in spherical geometry. Various boundary conditions are adopted, ranging from fully prescribed cases where all boundaries are assigned with the semi-analytic models, to solar-like cases where only the magnetic field at the bottom is known. Our results demonstrate that all the metrics compare favorably to previous works in both Cartesian and spherical coordinates. Cases with several AMR levels perform in accordance with their effective resolutions. The magneto-frictional method in MPI-AMRVAC allows us to model a region of interest with high spatial resolution and large field of view simultaneously, as required by observation-constrained extrapolations using vector data provided with modern instruments. The applications of the magneto-frictional method to observations are shown in an accompanying paper
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