7,068 research outputs found
Steady Bell state generation via magnon-photon coupling
We show that parity-time () symmetry can be spontaneously
broken in the recently reported energy level attraction of magnons and cavity
photons. In the -broken phase, magnon and photon form a
high-fidelity Bell state with maximum entanglement. This entanglement is steady
and robust against the perturbation of environment, in contrast to the general
wisdom that expects instability of the hybridized state when the symmetry is
broken. This anomaly is further understood by the compete of non-Hermitian
evolution and particle number conservation of the hybridized system. As a
comparison, neither -symmetry broken nor steady magnon-photon
entanglement is observed inside the normal level repulsion case. Our results
may open a novel window to utilize magnon-photon entanglement as a resource for
quantum technologies.Comment: 5 pages, 4 figure
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Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling.
Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced cardiac apoptosis in vivo and in vitro via regulating HIF-1α signalling pathway. Rat myocardial I/R was induced by occluding the left anterior descending artery for 30 minutes followed by 6-hours reperfusion, and cardiomyocyte hypoxia/reoxygenation (H/R) was induced by oxygen-glucose deprivation for 6 hours followed by 3-hours reoxygenation. Dexmedetomidine administration at the beginning of reperfusion or reoxygenation attenuated I/R-induced myocardial injury or H/R-induced cell death, alleviated mitochondrial dysfunction, reduced the number of apoptotic cardiomyocytes, inhibited the activation of HIF-1α and modulated the expressions of apoptosis-related proteins including BCL-2, BAX, BNIP3, cleaved caspase-3 and cleaved PARP. Conversely, the HIF-1α prolyl hydroxylase-2 inhibitor IOX2 partly blocked DEX-mediated cardioprotection both in vivo and in vitro. Mechanistically, DEX down-regulated HIF-1α expression at the post-transcriptional level and inhibited the transcriptional activation of the target gene BNIP3. Post-treatment with DEX protects against cardiac I/R injury in vivo and H/R injury in vitro. These effects are, at least in part, mediated via the inhibition of cell apoptosis by targeting HIF-1α signalling
Low-molecular-weight heparin in addition to low-dose aspirin for preventing preeclampsia and its complications: A systematic review and meta-analysis
BackgroundIn this systematic review, we aimed to investigate the efficacy and safety of adding low-molecular-weight heparin (LMWH) or unfractionated heparin to low-dose aspirin (LDA) started ≤16 weeks'gestation in the prevention of preeclampsia (PE) in high-risk women.MethodsPubMed, Cochrane Library, Embase, and ClinicalTrials.gov databases were searched from their inception to April 2022 for randomized controlled trials (RCTs) that to determine whether the combined treatment of LMWH and LDA is better than single anticoagulant drugs in preventing PE and improving live birth rate of fetus in high-risk women with pregnancy ≤16 weeks. We also searched Embase, OVID MEDLINE and OVID MEDLINE in-process using the OVID platform.Results14 RCTs involving 1,966 women were found. The LMWH (or unfractionated heparin) and LDA groups included 1,165 wemen, and the LDA group included 960 women. The meta-analysis showed that the addition of LMWH to LDA reduced the risk of PE (RR: 0.59, 95% CI: 0.44-0.79, P < 0.05), small-for-gestational age (SGA, RR: 0.71, 95% CI: 0.52-0.97, P = 0.03), fetal and neonatal death (RR: 0.45, 95% CI: 0.23-0.88, P = 0.02) and gestational hypertension (RR: 0.47, 95% CI: 0.25-0.90, P = 0.02). It is worth emphasizing that LMWH (or unfractionated heparin) combined with LDA did not increase the risk of bleeding.ConclusionsLMWH combined with LDA can effectively improve the pregnancy outcome of women with high risk factors for PE and its complications. Although this study showed that combined medication also did not increase the risk of bleeding, but such results lack the support of large sample size studies. The clinical safety analysis of LMWH combined with LDA in patients with PE should be more carried out
Hierarchical Integration Diffusion Model for Realistic Image Deblurring
Diffusion models (DMs) have recently been introduced in image deblurring and
exhibited promising performance, particularly in terms of details
reconstruction. However, the diffusion model requires a large number of
inference iterations to recover the clean image from pure Gaussian noise, which
consumes massive computational resources. Moreover, the distribution
synthesized by the diffusion model is often misaligned with the target results,
leading to restrictions in distortion-based metrics. To address the above
issues, we propose the Hierarchical Integration Diffusion Model (HI-Diff), for
realistic image deblurring. Specifically, we perform the DM in a highly
compacted latent space to generate the prior feature for the deblurring
process. The deblurring process is implemented by a regression-based method to
obtain better distortion accuracy. Meanwhile, the highly compact latent space
ensures the efficiency of the DM. Furthermore, we design the hierarchical
integration module to fuse the prior into the regression-based model from
multiple scales, enabling better generalization in complex blurry scenarios.
Comprehensive experiments on synthetic and real-world blur datasets demonstrate
that our HI-Diff outperforms state-of-the-art methods. Code and trained models
are available at https://github.com/zhengchen1999/HI-Diff.Comment: Code is available at https://github.com/zhengchen1999/HI-Dif
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