AN ANALYSIS OF AFFECTION ON THE WATER TRANSPARENCY FACTOR OF WEST LAKE

This paper is a special topic study on affecting the water transparency factor and supervising the water transparency of West Lake, 10 years in succession, and expounds the present situation variable, regularity variable, reasons and improvement methods to the water transparency of West Lake systematically and thoroughly. It gains the conclusion that the water transparency of West Lake bears less relationship with the dissolved substance, and the water transparency is mainly affected by the suspended substance. Because the nutrient substance from the base sludge dissolves out and takes place biological transformation very quick, the phosphorus density has a certain drop, however not affecting the growth and propagation of the algae, and not presenting the phenomena of the phosphorus inhibition. We regard the phosphorus isn't the nutrient element inhibiting the algae growth.Article信州大学理学部附属諏訪臨湖実験所報告 11: 3-12(1999)departmental bulletin pape

ADMINISTRATION OF THE WEST LAKE WATER AREA, HANGZHOU

The comparison test of the function of aquatic biology, such as Viviparidae, Hyriopsis Cvmingiilleal, water spinach and underwater plants on the purification of the water body, has been made in the test area of West Lake. The result shows that the spiral is the test one to improve the transparency of the water body, then the Hyriopsis Cvmingiilleal, water spinach and underwater plant in succession. At the same time planting method, raising density, purification function of water body, and the possibility of planting, have been studied.Article信州大学理学部附属諏訪臨湖実験所報告 11: 13-20(1999)departmental bulletin pape

Data_Sheet_1_Association between red blood cell distribution width-to-albumin ratio and the prognosis in patients with autoimmune encephalitis: a retrospective cohort study.docx

AimRed blood cell distribution width-to-albumin ratio (RAR) is a combined new indicator reflecting immunology and has been reported to predict the prognosis of inflammation-related diseases and brain diseases. However, the association and predictive value of RAR in the prognosis of patients with autoimmune encephalitis (AE) has not been reported.MethodsThis was a retrospective cohort study, and data were collected from the Henan Provincial People’s Hospital. RAR was categorized according to quartile. The prognosis was assessed using the modified Rankin Scale (mRS), and an mRS score of ≥3 was defined as a poor prognosis. The logistical regression model was used to explore the association between RAR and the prognosis, with results reported as odds ratio (OR) and 95% confidence interval (CI). The predictive value of RAR was evaluated by calculating the area under the receiving operating curve (AUC), sensitivity, specificity, and accuracy.ResultsA total of 175 eligible patients were included for analysis, and 51 patients were identified as having poor prognosis. After adjusting age, cancer, other diseases, histological subtype, antiepileptic therapy, anti-tumor treatment, ICU treatment, and length of stay, RAR in the highest quartile (Q4) was found to be significantly associated with the high odds of poor prognosis (OR = 5.63, 95%CI: 1.98–16.02) compared to RAR in the lowest quartile (Q1). In addition, RAR was identified as a predictor for the prognosis of AE patients (AUC = 0.660, 95%CI: 0.574–0.746).ConclusionThis study found the close association and predictive value of RAR for the prognosis of AE patients, indicating that RAR might help clinicians identify high-risk populations.</p

IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma

<p>Allergic asthma is a common airway inflammatory disease in which B cells play important roles through IgE production and antigen presentation. SNP (single nucleotide polymorphism) analysis showed that <i>Atg</i> (autophagy-related) allele mutations are involved in asthma. It has been demonstrated that macroautophagy/autophagy is essential for B cell survival, plasma cell differentiation and immunological memory maintenance. However, whether B cell autophagy participates in asthma pathogenesis remains to be investigated. In this report, we found that autophagy was enhanced in pulmonary B cells from asthma-prone mice. Autophagy deficiency in B cells led to attenuated immunopathological symptoms in asthma-prone mice. Further investigation showed that IL4 (interleukin 4), a key effector Th2 cytokine in allergic asthma, was critical for autophagy induction in B cells both in vivo and in vitro, which further sustained B cell survival and enhanced antigen presentation by B cells. Moreover, IL4-induced autophagy depended on JAK signaling via an MTOR-independent, PtdIns3K-dependent pathway. Together, our data indicate that B cell autophagy aggravates experimental asthma through multiple mechanisms.</p

Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line

<p>The differential steroid production in the theca and granulosa cells in ovary are resulted from unique enzyme expression profiles. Among them, c-fos, a downstream target of mitogen and extracellular signal-regulated kinases (MEK/ERK) signaling, takes part in this compartment. In this study, we investigated the effect of c-fos on the steady-state levels of CYP17 and CYP19 in human ovarian granulosa-like tumor cell line (KGN) by inhibiting MEK/ERK pathway with PD98059. As a result, our finding demonstrated the distinct distribution patterns of CYP17 and CYP19 in KGN. Moreover, the MEK/ERK pathway functions to inhibit the production of CYP17, while enhance the production of CYP19 in granulosa cells, probably involving a c-fos-dependent mechanism. In conclusion, factors such as c-fos may play a crucial role in the down-regulation of CYP17 and up-regulation of CYP19 in granulosa cells, thereby suppressing androstenedione synthesis.</p