328 research outputs found
5-Methyl-N-[2-(trifluoroÂmethÂyl)phenÂyl]isoxazole-4-carboxamide
In the title compound, C12H9F3N2O2, the benzene ring is nearly perpendicular to the isoxazole ring, making a dihedral angle of 82.97 (2)°. In the crystal, molÂecules are linked by N—H⋯O hydrogen bonds into a supraÂmolecular chain running along the c axis
Lithium tantalate electro-optical photonic integrated circuits for high volume manufacturing
Photonic integrated circuits based on Lithium Niobate have demonstrated the
vast capabilities afforded by material with a high Pockels coefficient,
allowing linear and high-speed modulators operating at CMOS voltage levels for
applications ranging from data-center communications and photonic accelerators
for AI. However despite major progress, the industrial adoption of this
technology is compounded by the high cost per wafer. Here we overcome this
challenge and demonstrate a photonic platform that satisfies the dichotomy of
allowing scalable manufacturing at low cost, while at the same time exhibiting
equal, and superior properties to those of Lithium Niobate. We demonstrate that
it is possible to manufacture low loss photonic integrated circuits using
Lithium Tantalate, a material that is already commercially adopted for acoustic
filters in 5G and 6G. We show that LiTaO3 posses equally attractive optical
properties and can be etched with high precision and negligible residues using
DUV lithography, diamond like carbon (DLC) as a hard mask and alkaline wet
etching. Using this approach we demonstrate microresonators with an intrinsic
cavity linewidth of 26.8 MHz, corresponding to a linear loss of 5.6 dB/m and
demonstrate a Mach Zehnder modulator with Vpi L = 4.2 V cm half-wave voltage
length product. In comparison to Lithium Niobate, the photonic integrated
circuits based on LiTaO3 exhibit a much lower birefringence, allowing
high-density circuits and broadband operation over all telecommunication bands
(O to L band), exhibit higher photorefractive damage threshold, and lower
microwave loss tangent. Moreover, we show that the platform supports generation
of soliton microcombs in X-Cut LiTaO3 racetrack microresonator with
electronically detectable repetition rate, i.e. 30.1 GHz.Comment: 8 pages, 4 figure
Exploring the Potential of Integrated Optical Sensing and Communication (IOSAC) Systems with Si Waveguides for Future Networks
Advanced silicon photonic technologies enable integrated optical sensing and
communication (IOSAC) in real time for the emerging application requirements of
simultaneous sensing and communication for next-generation networks. Here, we
propose and demonstrate the IOSAC system on the silicon nitride (SiN) photonics
platform. The IOSAC devices based on microring resonators are capable of
monitoring the variation of analytes, transmitting the information to the
terminal along with the modulated optical signal in real-time, and replacing
bulk optics in high-precision and high-speed applications. By directly
integrating SiN ring resonators with optical communication networks,
simultaneous sensing and optical communication are demonstrated by an optical
signal transmission experimental system using especially filtering amplified
spontaneous emission spectra. The refractive index (RI) sensing ring with a
sensitivity of 172 nm/RIU, a figure of merit (FOM) of 1220, and a detection
limit (DL) of 8.2*10-6 RIU is demonstrated. Simultaneously, the 1.25 Gbps
optical on-off-keying (OOK) signal is transmitted at the concentration of
different NaCl solutions, which indicates the bit-error-ratio (BER) decreases
with the increase in concentration. The novel IOSAC technology shows the
potential to realize high-performance simultaneous biosensing and communication
in real time and further accelerate the development of IoT and 6G networks.Comment: 11pages, 5 figutre
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays.
Spatially resolved transcriptomic technologies are promising tools to study complex biological processes such as mammalian embryogenesis. However, the imbalance between resolution, gene capture, and field of view of current methodologies precludes their systematic application to analyze relatively large and three-dimensional mid- and late-gestation embryos. Here, we combined DNA nanoball (DNB)-patterned arrays and in situ RNA capture to create spatial enhanced resolution omics-sequencing (Stereo-seq). We applied Stereo-seq to generate the mouse organogenesis spatiotemporal transcriptomic atlas (MOSTA), which maps with single-cell resolution and high sensitivity the kinetics and directionality of transcriptional variation during mouse organogenesis. We used this information to gain insight into the molecular basis of spatial cell heterogeneity and cell fate specification in developing tissues such as the dorsal midbrain. Our panoramic atlas will facilitate in-depth investigation of longstanding questions concerning normal and abnormal mammalian development.This work is part of the ‘‘SpatioTemporal Omics Consortium’’ (STOC) paper package. A list of STOC members is available at: http://sto-consortium.org. We would
like to thank the MOTIC China Group, Rongqin Ke (Huaqiao University, Xiamen,
China), Jiazuan Ni (Shenzhen University, Shenzhen, China), Wei Huang (Center
for Excellence in Brain Science and Intelligence Technology, Chinese Academy
of Sciences, Shanghai, China), and Jonathan S. Weissman (Whitehead Institute,
Boston, USA) for their help. This work was supported by the grant of Top Ten
Foundamental Research Institutes of Shenzhen, the Shenzhen Key Laboratory
of Single-Cell Omics (ZDSYS20190902093613831), and the Guangdong Provincial Key Laboratory of Genome Read and Write (2017B030301011); Longqi Liu
was supported by the National Natural Science Foundation of China
(31900466) and Miguel A. Esteban’s laboratory at the Guangzhou Institutes of
Biomedicine and Health by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030502), National Natural Science Foundation of China (92068106), and the Guangdong Basic and Applied Basic Research
Foundation (2021B1515120075).S
Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and the fourth most lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little of the mutational processes responsible. To identify genome-wide mutational signatures, we performed either whole-genome sequencing (WGS) or whole-exome sequencing (WES) on 104 ESCC individuals and combined our data with those of 88 previously reported samples. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in ESCC. Moreover, PIK3CA hotspot mutations (c.1624G>A [p.Glu542Lys] and c.1633G>A [p.Glu545Lys]) were enriched in APOBEC-signature tumors, and no smoking-associated signature was observed in ESCC. In the samples analyzed by WGS, we identified focal (<100 kb) amplifications of CBX4 and CBX8. In our combined cohort, we identified frequent inactivating mutations in AJUBA, ZNF750, and PTCH1 and the chromatin-remodeling genes CREBBP and BAP1, in addition to known mutations. Functional analyses suggest roles for several genes (CBX4, CBX8, AJUBA, and ZNF750) in ESCC. Notably, high activity of hedgehog signaling and the PI3K pathway in approximately 60% of 104 ESCC tumors indicates that therapies targeting these pathways might be particularly promising strategies for ESCC. Collectively, our data provide comprehensive insights into the mutational signatures of ESCC and identify markers for early diagnosis and potential therapeutic targets
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