10 research outputs found
Long-term incorporation of manure with chemical fertilizers reduced total nitrogen loss in rain-fed cropping systems
No full textLong-term combined application of manure and NPK fertilizers influenced nitrogen retention and stabilization of organic C in Loess soil
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Challenges of hemodialysis in Vietnam: experience from the first standardized district dialysis unit in Ho Chi Minh City
No full textComparison of straw-biochar-mediated changes in nitrification and ammonia oxidizers in agricultural oxisols and cambosols
No full textExpression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
No full textDendritic cells (DCs), known to support immune activation during infections, may also regulate immune homeostasis in resting animals. Here we show that mice lacking A20 specifically in DCs spontaneously exhibited DC activation and expansion of activated T cells. DC-specific epistasis experiments using A20(fl/fl) Myd88(fl/fl) Cd11c-Cre compound mice revealed that A20 restricts both MyD88-independent signals, which drive DC and T cell activation, and MyD88-dependent signals, which drive T cell expansion. In addition, A20(fl/fl) Cd11c-Cre mice spontaneously developed lymphocyte-dependent colitis, sero-negative ankylosing arthritis and enthesitis, conditions stereotypical for human inflammatory bowel disease (IBD). These findings indicate that DCs require A20 to preserve immune quiescence and suggest that A20-dependent DC functions may underlie IBD and IBD-associated arthritides
Redox-responsive micelles self-assembled from multi-block copolymer for co-delivery of siRNA and hydrophobic anticancer drug
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