271 research outputs found
Local transformation of mixed states of two qubits to Bell diagonal states
The optimal entanglement manipulation for a single copy of mixed states of
two qubits is to transform it to a Bell diagonal state. In this paper we derive
an explicit form of the local operation that can realize such a transformation.
The result obtained is universal for arbitrary entangled two-qubit states and
it discloses that the corresponding local filter is not unique for density
matrices with rank and can be exclusively determined for that with
and 4. As illustrations, a four-parameters family of mixed states are explored,
the local filter as well as the transformation probability are given
explicitly, which verify the validity of the general result.Comment: 5 pages, to be published in Phys. Rev.
Sketch-based modeling with a differentiable renderer
© 2020 The Authors. Computer Animation and Virtual Worlds published by John Wiley & Sons, Ltd. Sketch-based modeling aims to recover three-dimensional (3D) shape from two-dimensional line drawings. However, due to the sparsity and ambiguity of the sketch, it is extremely challenging for computers to interpret line drawings of physical objects. Most conventional systems are restricted to specific scenarios such as recovering for specific shapes, which are not conducive to generalize. Recent progress of deep learning methods have sparked new ideas for solving computer vision and pattern recognition issues. In this work, we present an end-to-end learning framework to predict 3D shape from line drawings. Our approach is based on a two-steps strategy, it converts the sketch image to its normal image, then recover the 3D shape subsequently. A differentiable renderer is proposed and incorporated into this framework, it allows the integration of the rendering pipeline with neural networks. Experimental results show our method outperforms the state-of-art, which demonstrates that our framework is able to cope with the challenges in single sketch-based 3D shape modeling
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
Rett syndrome (RTT) is an inherited neurodevelopmental disorder
of females that occurs once in 10,000–15,000 births1,2.
Affected females develop normally for 6–18 months, but then
lose voluntary movements, including speech and hand skills.
Most RTT patients are heterozygous for mutations in the Xlinked
gene MECP2 (refs. 3–12), encoding a protein that binds
to methylated sites in genomic DNA and facilitates gene silencing13–
17. Previous work with Mecp2-null embryonic stem cells
indicated that MeCP2 is essential for mouse embryogenesis18.
Here we generate mice lacking Mecp2 using Cre-loxP technology.
Both Mecp2-null mice and mice in which Mecp2 was
deleted in brain showed severe neurological symptoms at
approximately six weeks of age. Compensation for absence of
MeCP2 in other tissues by MeCP1 (refs. 19,20) was not apparent
in genetic or biochemical tests. After several months, heterozygous
female mice also showed behavioral symptoms. The overlapping
delay before symptom onset in humans and mice,
despite their profoundly different rates of development, raises
the possibility that stability of brain function, not brain development
per se, is compromised by the absence of MeCP2
Construction and On-site Performance of the LHAASO WFCTA Camera
The focal plane camera is the core component of the Wide Field-of-view
Cherenkov/fluorescence Telescope Array (WFCTA) of the Large High-Altitude Air
Shower Observatory (LHAASO). Because of the capability of working under
moonlight without aging, silicon photomultipliers (SiPM) have been proven to be
not only an alternative but also an improvement to conventional photomultiplier
tubes (PMT) in this application. Eighteen SiPM-based cameras with square light
funnels have been built for WFCTA. The telescopes have collected more than 100
million cosmic ray events and preliminary results indicate that these cameras
are capable of working under moonlight. The characteristics of the light
funnels and SiPMs pose challenges (e.g. dynamic range, dark count rate,
assembly techniques). In this paper, we present the design features,
manufacturing techniques and performances of these cameras. Finally, the test
facilities, the test methods and results of SiPMs in the cameras are reported
here.Comment: 45 pages, 21 figures, articl
DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery
To address the increasing need for detecting and validating protein biomarkers in clinical specimens, mass spectrometry (MS)-based targeted proteomic techniques, including the selected reaction monitoring (SRM), parallel reaction monitoring (PRM), and massively parallel data-independent acquisition (DIA), have been developed. For optimal performance, they require the fragment ion spectra of targeted peptides as prior knowledge. In this report, we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue samples. To build the spectral resource, we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on Docker. We then applied the workflow to generate DPHL, a comprehensive DIA pan-human library, from 1096 data-dependent acquisition (DDA) MS raw files for 16 types of cancer samples. This extensive spectral resource was then applied to a proteomic study of 17 prostate cancer (PCa) patients. Thereafter, PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was validated. As a second application, the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma (DLBCL) patients and 18 healthy control subjects. Differentially expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by PRM. These data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker discovery. DPHL is freely accessible at https://www.iprox.org/page/project.html?id=IPX0001400000
Does or did the supernova remnant Cassiopeia A operate as a PeVatron?
For decades, supernova remnants (SNRs) have been considered the prime sources
of Galactic Cosmic rays (CRs). But whether SNRs can accelerate CR protons to
PeV energies and thus dominate CR flux up to the knee is currently under
intensive theoretical and phenomenological debate. The direct test of the
ability of SNRs to operate as CR PeVatrons can be provided by ultrahigh-energy
(UHE; ~TeV) -rays. In this context, the historical
SNR Cassiopeia A (Cas A) is considered one of the most promising target for UHE
observations. This paper presents the observation of Cas A and its vicinity by
the LHAASO KM2A detector. The exceptional sensitivity of LHAASO KM2A in the UHE
band, combined with the young age of Cas A, enabled us to derive stringent
model-independent limits on the energy budget of UHE protons and nuclei
accelerated by Cas A at any epoch after the explosion. The results challenge
the prevailing paradigm that Cas A-type SNRs are major suppliers of PeV CRs in
the Milky Way.Comment: 11 pages, 3 figures, Accepted by the APJ
Measurement of ultra-high-energy diffuse gamma-ray emission of the Galactic plane from 10 TeV to 1 PeV with LHAASO-KM2A
The diffuse Galactic -ray emission, mainly produced via interactions
between cosmic rays and the interstellar medium and/or radiation field, is a
very important probe of the distribution, propagation, and interaction of
cosmic rays in the Milky Way. In this work we report the measurements of
diffuse -rays from the Galactic plane between 10 TeV and 1 PeV
energies, with the square kilometer array of the Large High Altitude Air Shower
Observatory (LHAASO). Diffuse emissions from the inner
(, ) and outer
(, ) Galactic plane are detected with
and significance, respectively. The outer Galactic
plane diffuse emission is detected for the first time in the very- to
ultra-high-energy domain (~TeV). The energy spectrum in the inner Galaxy
regions can be described by a power-law function with an index of
, which is different from the curved spectrum as expected from
hadronic interactions between locally measured cosmic rays and the
line-of-sight integrated gas content. Furthermore, the measured flux is higher
by a factor of than the prediction. A similar spectrum with an index of
is found in the outer Galaxy region, and the absolute flux for
TeV is again higher than the prediction for hadronic
cosmic ray interactions. The latitude distributions of the diffuse emission are
consistent with the gas distribution, while the longitude distributions show
clear deviation from the gas distribution. The LHAASO measurements imply that
either additional emission sources exist or cosmic ray intensities have spatial
variations.Comment: 12 pages, 8 figures, 5 tables; accepted for publication in Physical
Review Letters; source mask file provided as ancillary fil
Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population
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