Muscle recovery after ACL reconstruction with 4-strand semitendinosus graft harvested through either a posterior or anterior incision: A preliminary study

AbstractIntroductionHarvesting of a 4-strand semitendinosis (ST4) graft during anterior cruciate ligament (ACL) reconstruction can be performed through either a posterior or anterior approach. The objective of this study was to evaluate the recovery of the quadriceps and hamstring muscles as a function of the graft harvesting method. We hypothesized that posterior harvesting (PH) would lead to better recovery in hamstring strength than anterior harvesting (AH).MethodsIn this prospective study, the semitendinosus was harvested through an anterior incision in the first group of patients and through a posterior one in the second group of patients. The patients were enrolled consecutively, without randomization. Isokinetic muscle testing was performed three and six months postoperative to determine the strength deficit in the quadriceps and hamstring muscles of the operated leg relative to the uninjured contralateral leg.ResultsThirty-nine patients were included: 20 in the AH group and 19 in the PH group. The mean quadriceps strength deficit after three and six months was 42% and 26% for AH and 29% and 19% for the PH, respectively (P=0.01 after three months and P=0.16 after six months). The mean hamstring strength deficit after three and six months was 31% and 17% for AH and 23% and 15% for the PH, respectively (P=0.09 after three months and P=0.45 after six months). After three months, the PH group had recovered 12% more quadriceps muscle strength than the AH group (P=0.03).ConclusionOur hypothesis was not confirmed. Harvesting of a ST4 graft for ACL reconstruction using a posterior approach led to better muscle strength recovery in the quadriceps only after three months.Case control studyLevel 3

A New Process-Based Soil Methane Scheme:Evaluation Over Arctic Field Sites With the ISBA Land Surface Model

Permafrost soils and arctic wetlands methane emissions represent an important challenge for modeling the future climate. Here we present a process-based model designed to correctly represent the main thermal, hydrological, and biogeochemical processes related to these emissions for general land surface modeling. We propose a new multilayer soil carbon and gas module within the Interaction Soil-Biosphere-Atmosphere (ISBA) land-surface model (LSM). This module represents carbon pools, vertical carbon dynamics, and both oxic and anoxic organic matter decomposition. It also represents the soil gas processes for CH4, CO2, and O2 through the soil column. We base CH4 production and oxydation on an O2 control instead of the classical water table level strata approach used in state-of-the-art soil CH4 models. We propose a new parametrization of CH4 oxydation using recent field experiments and use an explicit O2 limitation for soil carbon decomposition. Soil gas transport is computed explicitly, using a revisited formulation of plant-mediated transport, a new representation of gas bulk diffusivity in porous media closer to experimental observations, and an innovative advection term for ebullition. We evaluate this advanced model on three climatically distinct sites : two in Greenland (Nuuk and Zackenberg) and one in Siberia (Chokurdakh). The model realistically reproduces methane and carbon dioxide emissions from both permafrosted and nonpermafrosted sites. The evolution and vertical characteristics of the underground processes leading to these fluxes are consistent with current knowledge. Results also show that physics is the main driver of methane fluxes, and the main source of variability appears to be the water table depth

SearchCal: a Virtual Observatory tool for searching calibrators in optical long baseline interferometry. I: The bright object case

In long baseline interferometry, the raw fringe contrast must be calibrated to obtain the true visibility and then those observables that can be interpreted in terms of astrophysical parameters. The selection of suitable calibration stars is crucial for obtaining the ultimate precision of interferometric instruments like the VLTI. We have developed software SearchCal that builds an evolutive catalog of stars suitable as calibrators within any given user-defined angular distance and magnitude around the scientific target. We present the first version of SearchCal dedicated to the bright-object case V<=10; K<=5). Star catalogs available at the CDS are consulted via web requests. They provide all the useful information for selecting of calibrators. Missing photometries are computed with an accuracy of 0.1 mag and the missing angular diameters are calculated with a precision better than 10%. For each star the squared visibility is computed by taking the wavelength and the maximum baseline of the foreseen observation into account.} SearchCal is integrated into ASPRO, the interferometric observing preparation software developed by the JMMC, available at the address: http://mariotti.fr

Quenched Chiral Perturbation Theory for Vector Mesons

We develop quenched chiral perturbation theory for vector mesons made of light quarks, in the limit where the vector meson masses are much larger than the pion mass. We use this theory to extract the leading nonanalytic dependence of the vector meson masses on the masses of the light quarks. By comparing with analogous quantities computed in ordinary chiral perturbation theory, we estimate the size of quenching effects, observing that in general they can be quite large. This estimate is relevant to lattice simulations, where the $\rho$ mass is often used to set the lattice spacing.Comment: 18 pages, 8 figures, uses REVTeX and epsf.st

Modeling the strangeness content of hadronic matter

The strangeness content of hadronic matter is studied in a string-flip model that reproduces various aspects of the QCD-inspired phenomenology, such as quark clustering at low density and color deconfinement at high density, while avoiding long range van der Waals forces. Hadronic matter is modeled in terms of its quark constituents by taking into account its internal flavor (u,d,s) and color (red, blue, green) degrees of freedom. Variational Monte-Carlo simulations in three spatial dimensions are performed for the ground-state energy of the system. The onset of the transition to strange matter is found to be influenced by weak, yet not negligible, clustering correlations. The phase diagram of the system displays an interesting structure containing both continuous and discontinuous phase transitions. Strange matter is found to be absolutely stable in the model.Comment: 14 pages, 1 table, 8 eps figures, revtex. Submitted to Phys. Rev. C, Presented at INPC2001 Berkeley, Ca. july 29-Aug

Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with a high prevalence of hypertension. NZBWF1 (SLE-Hyp) mice develop hypertension that can be prevented by modulating T cells. The peptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) decreases renal damage and improves renal function in a model of SLE without hypertension (MRL/lpr). However, it is not known whether Ac-SDKP prevents hypertension in NZBWF1 mice. We hypothesized that in SLE-Hyp, Ac-SDKP prevents hypertension and renal damage by modulating T cells. Animals were divided into four groups: (1) control + vehicle, (2) control + Ac-SDKP, (3) SLE + vehicle, and (4) SLE + Ac-SDKP Systolic blood pressure (SBP), albuminuria, renal fibrosis, and T-cell phenotype were analyzed. SBP was higher in SLE compared to control mice and was not decreased by Ac-SDKP treatment. Half of SLE mice developed an acute and severe form of hypertension accompanied by albuminuria followed by death. Ac-SDKP delayed development of severe hypertension, albuminuria, and early mortality, but this delay did not reach statistical significance. Ac-SDKP prevented glomerulosclerosis, but not interstitial fibrosis in SLE-Hyp mice. SLE-Hyp mice showed a decrease in helper and cytotoxic T cells as well as an increase in double negative lymphocytes and T helper 17 cells, but these cells were unaffected by Ac-SDKP In conclusion, Ac-SDKP prevents kidney damage, without affecting blood pressure in an SLE animal model. However, during the acute relapse of SLE, Ac-SDKP might also delay the manifestation of an acute and severe form of hypertension leading to early mortality. Ac-SDKP is a potential tool to treat renal damage in SLE-Hyp mice