Declining Rotation Curve and Brown Dwarf MACHOs

If the Galactic rotation speed at the Solar circle is $\sim 200$ km s$^{-1}$ or smaller, which is supported by several recent studies, the rotation curve of the Galaxy could be declining in the outermost region. Motivated by this, we investigate the effect of such declining rotation curve on the estimate of the MACHO mass and the fractional contribution of the MACHOs to the Galactic dark halo. Using Hernquist and Plummer halo models instead of the standard halo model, we find that the MACHO mass could be significantly smaller than that for the standard halo case. In particular, there exists a certain set of halo parameters for which the MACHO mass is 0.1$M_\odot$ or less and at the same time the MACHO contribution to the total mass of the halo is almost 100 %. This result indicates that a halo which consists solely of brown dwarfs can be consistent with both of the observed microlensing properties and the constraints from the rotation curve, provided the outer rotation curve is indeed declining.Comment: 8 pages and 4 figures, accepted for publication in ApJ Letter

Digital Art Capture (DAC): Software For System Control

This paper presents the results of a project whose aim was to design, develop and write 20,000 lines of computer program code incorporating feedback loops for real time control of a motorised mechanical and optical hardware syste

Superconducting gap variations induced by structural supermodulation in BSCCO

We discuss the possibility that the strain field introduced by the structural supermodulation in Bi-2212 and certain other cuprate materials may modulate the superconducting pairing interaction. We calculate the amplitude of this effect, visible in scanning tunneling spectroscopy experiments, and thereby relate a change in the local superconducting gap with the change in the local dopant displacements induced by the supermodulation. In principle, since this modulation is periodic, sufficiently accurate x-ray measurements or ab initio calculations should enable one to determine which atomic displacements enhance pairing and therefore T_c.Comment: 4 pages, 3 figure

Patient-specific virtual stent-graft deployment for Type B aortic dissection: a pilot study of the impact of stent-graft length

Thoracic endovascular aortic repair (TEVAR) has been accepted as a standard treatment option for complicated type B aortic dissection. Distal stent-graft induced new entry (SINE) is recognized as one of the main post-TEVAR complications, which can lead to fatal prognosis. Previous retrospective cohort studies suggested that short stent-graft (SG) length (<165 mm) might correlate with increased risk of distal SINE. However, the influence of SG length on changes in local biomechanical conditions before and after TEVAR is unknown. In this paper, we aim to address this issue using a virtual SG deployment simulation model developed for application in type B aortic dissection. Our model incorporates detailed SG design and hyperelastic behaviour of the aortic wall. By making use of patient-specific geometry reconstructed from pre-TEVAR computed tomography angiography (CTA) scan, our model can predict post-TEVAR SG configuration and wall stress. Virtual SG deployment simulations were performed on a patient who underwent TEVAR with a short SG (158 mm in length), mimicking the actual clinical procedure. Further simulations were carried out on the same patient geometry but with different SG lengths (183 mm and 208 mm) in order to evaluate the effect of SG length on changes in local stress in the treated aorta

Nonsurgical repair of the ascending aorta: why less is more

Objective: Advanced endovascular options for acute and chronic pathology of the ascending aorta are emerging; however, several problems with stent grafts placed in the ascending aorta have been identified in patients unsuitable for surgical repair, such as migration and erosion at aorta interface. Method: Among the six cases analysed in this report, three were treated with a stent graft in the ascending aorta to manage chronic dissection in the proximal aorta; dimensions of those stent grafts varied between 34 and 45 mm in diameter, and from 77 to 100 mm in length. Three patients, matched by age, sex and their nature of pathology, were subjected to the focal closure of a single communicating entry by the use of an occluding device (Amplatzer ASD and PFO occluders between 14 and 18 mm disc diameter) with similar Charlson comorbidity score. Results: Both conceptually different nonsurgical management strategies were technically feasible; however, with stent grafts, an early or delayed erosion to full re-dissection was documented with stent grafts, in contrast to complete seal, with an induced remodelling and a long-term survival after the successful placing of coils and occluder devices. Moreover, aortic root motion was not impaired by the focal occlusion of a communication with an occluder, while free motion was impeded after stent graft placement. Conclusions: The intriguing observation in our small series was that stent grafts placed in the ascending aorta portends the risk of an either early (post-procedural) or delayed migration and erosion of aortic tissues at the landing site or biological interface between 12 and 16 months after the procedure, a phenomenon not seen with the use of focal occluding devices up to 5 years of follow-up. Obviously, the focal approach avoids the erosion of the aortic wall as the result of minimal interaction with the biological interface, such as a diseased aortic wall. Potential explanations may be related to a reduced motion of the aortic root after the placement of stent graft in the ascending aorta, whereas the free motion of aortic root was preserved with an occluder. The causality of erosion may however not be fully understood, as besides the stiffness and radial force of the stent graft, other factors such as the induced inflammatory reactions of aortic tissue and local adhesions within the chest may also play a role. With stent grafts failing to portend long-term success, they may still have a role as a temporizing solution for elective surgical conversion. Larger datasets from registries are needed to further explore this evolving field of interventions to the ascending aorta

URE and URA for Predicted LEO satellites Orbits at different altitudes

In recent years, low Earth orbit (LEO) satellites have been frequently discussed for their benefits in positioning and navigation services as an augmentation to the global navigation satellite systems (GNSSs). Similar to the positioning concept based on ranging to GNSS satellites, precise positioning of single-receiver users needs high-accuracy orbits and clocks of LEO satellites as a pre-condition. For real-time users, high prediction accuracies of these orbits at different latencies are needed. Unlike the satellite clocks, the GNSS orbits can be typically predicted for hours with high accuracy. LEO satellites, however, face more complicated perturbing dynamic terms due to their low altitudes. Therefore, the prediction accuracy and integrity of their orbits need to be addressed. In this study, using real data of three test LEO satellites GRACE C, Sentinel-1A and Sentinel-3B of different altitudes, various reduced-dynamic prediction strategies are assessed, with the appropriate methods selected for different prediction times up to 6 h. The global-averaged orbital user range errors (OUREs) are shown to be altitude-related. For the 700–800 km Sentinel satellites and 500 km GRACE satellite, the RMS of the OUREs is at sub-dm and dm-level for the prediction time of 1 h, respectively, and around 0.2 m and 0.6 m at the prediction time of 6 h, respectively. For integrity purposes, the worst-location OURE are calculated for the predicted orbits using a proposed algorithm considering the Earth as an Ellipsoid, not a sphere as usually done for the GNSS satellites. The orbital user range accuracy (OURA) is then evaluated for different prediction periods, having a time-dependent model proposed to compute the overbounding OURA at any prediction time within 6 h. With an integrity risk of 10 5, using hourly quadratic polynomials as the time-dependent model, the overbounding OURA is around 0.1 m at the prediction of 1 h, and at the sub-meter level for the prediction of 6 h for the Sentinel satellites. 2022 COSPAR. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org

Patient-specific simulation of stent-graft deployment in type B aortic dissection: model development and validation

Thoracic endovascular aortic repair (TEVAR) has been accepted as the mainstream treatment for type B aortic dissection, but post-TEVAR biomechanical-related complications are still a major drawback. Unfortunately, the stent-graft (SG) configuration after implantation and biomechanical interactions between the SG and local aorta are usually unknown prior to a TEVAR procedure. The ability to obtain such information via personalized computational simulation would greatly assist clinicians in pre-surgical planning. In this study, a virtual SG deployment simulation framework was developed for the treatment for a complicated aortic dissection case. It incorporates patient-specific anatomical information based on pre-TEVAR CT angiographic images, details of the SG design, and the mechanical properties of the stent wire, graft and dissected aorta. Hyperelastic material parameters for the aortic wall were determined based on uniaxial tensile testing performed on aortic tissue samples taken from type B aortic dissection patients. Pre-stress conditions of the aortic wall and the action of blood pressure were also accounted for. The simulated post-TEVAR configuration was compared with follow-up CT scans, demonstrating good agreement with mean deviations of 5.8% in local open area and 4.6 mm in stent strut position. Deployment of the SG increased the maximum principal stress by 24.30 KPa in the narrowed true lumen but reduced the stress by 31.38 KPa in the entry tear region where there was an aneurysmal expansion. Comparisons of simulation results with different levels of model complexity suggested that pre-stress of the aortic wall and blood pressure inside the stent-graft should be included in order to accurately predict the deformation of the deployed S

X-ray Dichroism and the Pseudogap Phase of Cuprates

A recent polarized x-ray absorption experiment on the high temperature cuprate superconductor Bi2Sr2CaCu2O8 indicates the presence of broken parity symmetry below the temperature, T*, where a pseudogap appears in photoemission. We critically analyze the x-ray data, and conclude that a parity-breaking signal of the kind suggested is unlikely based on the crystal structures reported in the literature. Possible other origins of the observed dichroism signal are discussed. We propose x-ray scattering experiments that can be done in order to determine whether such alternative interpretations are valid or not.Comment: final version to be published in Phys Rev B: some calculational details added, clarification of XNLD contamination and biaxiality, more discussion on possible space groups and previous optics result

Strategies for the production of maize-derived pharmaceuticals using cytoplasmic male sterile lines: In vitro tissue culture/transformation and field breeding approaches

Plant-made pharmaceuticals (PMPs) offer promise as efficient and cost-effective products for the treatment of human and animal diseases. An advantage of producing pharmaceuticals in maize is the large storage capacity and stability for proteins and starch in seed, allowing for manufacturing recombinant proteins such as antigens and antibodies. Other advantages of the maize system include safety, high yields, and scalability of production and processing. However, the benefits of this technology must be balanced against potential health and environmental risks that may be associated with its use. Because PMPs presently have no provision for regulatory tolerance, their inadvertent occurrence in foods and feeds remains an important economic consideration, even when the health and environmental risks are low. Pollen drift is considered a source of potential contamination of maizemade pharmaceuticals in the food chain. In addition to physical and temporal isolation requirements, open field pharmaceutical maize production also calls for controlled pollen release. Here, we describe two strategies to address the issue of transgenic pollen drift. First, we describe the development and genetic transformation of a tissue culture-amenable male-sterile line using biolistic- or Agrobacterium-mediated transformation methods. Secondly, we describe the introgression of a transgene from male-fertile transgenic maize to male-sterile germplasm by conventional breeding. After six seasons of breeding, this second strategy allows us to obtain 100% transgenic seeds from an open-field production using a non-transgenic line as the pollinator