Improved Hybrid Navigation for Space Transportation

This paper presents a tightly coupled hybrid navigation system for space transportation applications. The tightly integrated set-up, selected for its robustness and design flexibility, is here updated with GPS Pseudoranges and Time-Differenced GPS Carrier Phases (TDCP) to promote fast-dynamics estimation. The receiver clock errors affecting both GNSS observables are analysed and modelled. Tropospheric delay-rate is found to cause major disturbance to the TDCP during atmospheric ascent. A robust correction scheme for this effect is devised. Performance is evaluated using real GPS measurements

Aircraft Cockpit Ergonomic Layout Evaluation Based on Uncertain Linguistic Multiattribute Decision Making

In the view of the current cockpit information interaction, facilities and other characteristics are increasingly multifarious; the early layout evaluation methods based on single or partial components, often cause comprehensive evaluation unilateral, leading to the problems of long development period and low efficiency. Considering the fuzziness of ergonomic evaluation and diversity of evaluation information attributes, we refine and build an evaluation system based on the characteristics of the current cockpit man-machine layout and introduce the different types of uncertain linguistic multiple attribute combination decision making (DTULDM) method in the cockpit layout evaluation process. Meanwhile, we also establish an aircraft cockpit ergonomic layout evaluation model. Finally, an experiment about cockpit layout evaluation is given, and the result demonstrates that the proposed method about cockpit ergonomic layout evaluation is feasible and effective

PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway

Mixed lineage leukemia (MLL) fusion proteins directly activate the expression of key downstream genes such as MEIS1, HOXA9 to drive an aggressive form of human leukemia. However, it is still poorly understood what additional transcriptional regulators, independent of the MLL fusion pathway, contribute to the development of MLL leukemia. Here we show that the transcription factor PU.1 is essential for MLL leukemia and is required for the growth of MLL leukemic cells via the promotion of cell-cycle progression and inhibition of apoptosis. Importantly, PU.1 expression is not under the control of MLL fusion proteins. We further identified a PU.1-governed 15-gene signature, which contains key regulators in the MEIS-HOX program (MEIS1, PBX3, FLT3, and c-KIT). PU.1 directly binds to the genomic loci of its target genes in vivo, and is required to maintain active expression of those genes in both normal hematopoietic stem and progenitor cells and in MLL leukemia. Finally, the clinical significance of