1,982 research outputs found
Paramagnetic Resonance Absorption in Some Organic Biradicals
Four compounds of the form 4,4âČâpolymethylenebistriphenylmethyl, one compound of the form (1,4âphenylene)bisdiarylmethyl, three compounds of the form (4,4âČâbiphenylene)bisdiarylmethyl, and one compound, 4,4âČâoxybistriphenylmethyl have been shown to possess unpaired electrons by paramagnetic resonance absorption. The resonance spectra of 0.01 M solutions of these compounds in benzene exhibit a hyperfine structure arising from a spherically symmetrical contribution of the magnetic dipole interaction between the unpaired electron and the nuclear magnetic moments of the hydrogen atoms. The gâfactors for the compounds investigated in the first three classes were found to be 2.0025±0.0004 and 2.0031±0.0004 for the last compound. Such a close approach of the gâfactor to the free electron value plus the sharpness of the hyperfine structure lines indicates that the anisotropic contributions of the spinâorbit interaction, which would normally lift the degeneracy of the triplet state, are averaged out by the tumbling of the molecules.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70965/2/JCPSA6-25-4-697-1.pd
Scattering of cosmic strings by black holes: loop formation
We study the deformation of a long cosmic string by a nearby rotating black
hole. We examine whether the deformation of a cosmic string, induced by the
gravitational field of a Kerr black hole, may lead to the formation of a loop
of cosmic string. The segment of the string which enters the ergosphere of a
rotating black hole gets deformed and, if it is sufficiently twisted, it can
self-intersect chopping off a loop of cosmic string. We find that the formation
of a loop, via this mechanism, is a rare event. It will only arise in a small
region of the collision phase space, which depends on the string velocity, the
impact parameter and the black hole angular momentum. We conclude that
generically, the cosmic string is simply scattered or captured by the rotating
black hole.Comment: 11 pages, 2 figures, RevTe
Enhanced Peculiar Velocities in Brane-Induced Gravity
The mounting evidence for anomalously large peculiar velocities in our
Universe presents a challenge for the LCDM paradigm. The recent estimates of
the large scale bulk flow by Watkins et al. are inconsistent at the nearly 3
sigma level with LCDM predictions. Meanwhile, Lee and Komatsu have recently
estimated that the occurrence of high-velocity merging systems such as the
Bullet Cluster (1E0657-57) is unlikely at a 6.5-5.8 sigma level, with an
estimated probability between 3.3x10^{-11} and 3.6x10^{-9} in LCDM cosmology.
We show that these anomalies are alleviated in a broad class of
infrared-modifed gravity theories, called brane-induced gravity, in which
gravity becomes higher-dimensional at ultra large distances. These theories
include additional scalar forces that enhance gravitational attraction and
therefore speed up structure formation at late times and on sufficiently large
scales. The peculiar velocities are enhanced by 24-34% compared to standard
gravity, with the maximal enhancement nearly consistent at the 2 sigma level
with bulk flow observations. The occurrence of the Bullet Cluster in these
theories is 10^4 times more probable than in LCDM cosmology.Comment: 15 pages, 6 figures. v2: added reference
Extreme objects with arbitrary large mass, or density, and arbitrary size
We consider a generalization of the interior Schwarzschild solution that we
match to the exterior one to build global C^1 models that can have arbitrary
large mass, or density, with arbitrary size. This is possible because of a new
insight into the problem of localizing the center of symmetry of the models and
the use of principal transformations to understand the structure of space.Comment: 20 pages, 6 figures. Fixed one reference. Added a new equatio
The Dynamical Instability of Static, Spherically Symmetric Solutions in Nonsymmetric Gravitational Theories
We consider the dynamical stability of a class of static,
spherically-symmetric solutions of the nonsymmetric gravitational theory. We
numerically reproduce the Wyman solution and generate new solutions for the
case where the theory has a nontrivial fundamental length scale \mu^{-1}. By
considering spherically symmetric perturbations of these solutions we show that
the Wyman solutions are generically unstable.Comment: 13 pages, uses amslatex, graphicx and subfigure package
Structural and torsional properties of the RAD51-dsDNA nucleoprotein filament
Human RAD51 is a key protein in the repair of DNA by homologous recombination. Its assembly onto DNA, which induces changes in DNA structure, results in the formation of a nucleoprotein filament that forms the basis of strand exchange. Here, we determine the structural and mechanical properties of RAD51-dsDNA filaments. Our measurements use two recently developed magnetic tweezers assays, freely orbiting magnetic tweezers and magnetic torque tweezers, designed to measure the twist and torque of individual molecules. By directly monitoring changes in DNA twist on RAD51 binding, we determine the unwinding angle per RAD51 monomer to be 45°, in quantitative agreement with that of its bacterial homolog, RecA. Measurements of the torque that is built up when RAD51-dsDNA filaments are twisted show that under conditions that suppress ATP hydrolysis the torsional persistence length of the RAD51-dsDNA filament exceeds that of its RecA counterpart by a factor of three. Examination of the filament's torsional stiffness for different combinations of divalent ions and nucleotide cofactors reveals that the Ca2+ ion, apart from suppressing ATPase activity, plays a key role in increasing the torsional stiffness of the filament. These quantitative measurements of RAD51-imposed DNA distortions and accumulated mechanical stress suggest a finely tuned interplay between chemical and mechanical interactions within the RAD51 nucleoprotein filament
Isotropy, shear, symmetry and exact solutions for relativistic fluid spheres
The symmetry method is used to derive solutions of Einstein's equations for
fluid spheres using an isotropic metric and a velocity four vector that is
non-comoving. Initially the Lie, classical approach is used to review and
provide a connecting framework for many comoving and so shear free solutions.
This provides the basis for the derivation of the classical point symmetries
for the more general and mathematicaly less tractable description of Einstein's
equations in the non-comoving frame. Although the range of symmetries is
restrictive, existing and new symmetry solutions with non-zero shear are
derived. The range is then extended using the non-classical direct symmetry
approach of Clarkson and Kruskal and so additional new solutions with non-zero
shear are also presented. The kinematics and pressure, energy density, mass
function of these solutions are determined.Comment: To appear in Classical and Quantum Gravit
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SLC19A1 transports immunoreactive cyclic dinucleotides.
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway3. The binding of DNA to cGAS activates its enzymatic activity, leading to the synthesis of a second messenger, cyclic guanosine monophosphate-adenosine monophosphate (2'3'-cGAMP)4-7. This cyclic dinucleotide (CDN) activates STING8, which in turn activates the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor Îș-light-chain-enhancer of activated B cells (NF-ÎșB), promoting the transcription of genes encoding type I interferons and other cytokines and mediators that stimulate a broader immune response. Exogenous 2'3'-cGAMP produced by malignant cells9 and other CDNs, including those produced by bacteria10-12 and synthetic CDNs used in cancer immunotherapy13,14, must traverse the cell membrane to activate STING in target cells. How these charged CDNs pass through the lipid bilayer is unknown. Here we used a genome-wide CRISPR-interference screen to identify the reduced folate carrier SLC19A1, a folate-organic phosphate antiporter, as the major transporter of CDNs. Depleting SLC19A1 in human cells inhibits CDN uptake and functional responses, and overexpressing SLC19A1 increases both uptake and functional responses. In human cell lines and primary cells ex vivo, CDN uptake is inhibited by folates as well as two medications approved for treatment of inflammatory diseases, sulfasalazine and the antifolate methotrexate. The identification of SLC19A1 as the major transporter of CDNs into cells has implications for the immunotherapeutic treatment of cancer13, host responsiveness to CDN-producing pathogenic microorganisms11 and-potentially-for some inflammatory diseases
Magnetogenesis from Cosmic String Loops
Large-scale coherent magnetic fields are observed in galaxies and clusters,
but their ultimate origin remains a mystery. We reconsider the prospects for
primordial magnetogenesis by a cosmic string network. We show that the magnetic
flux produced by long strings has been overestimated in the past, and give
improved estimates. We also compute the fields created by the loop population,
and find that it gives the dominant contribution to the total magnetic field
strength on present-day galactic scales. We present numerical results obtained
by evolving semi-analytic models of string networks (including both one-scale
and velocity-dependent one-scale models) in a Lambda-CDM cosmology, including
the forces and torques on loops from Hubble redshifting, dynamical friction,
and gravitational wave emission. Our predictions include the magnetic field
strength as a function of correlation length, as well as the volume covered by
magnetic fields. We conclude that string networks could account for magnetic
fields on galactic scales, but only if coupled with an efficient dynamo
amplification mechanism.Comment: 10 figures; v3: small typos corrected to match published version.
MagnetiCS, the code described in paper, is available at
http://markcwyman.com/ and
http://www.damtp.cam.ac.uk/user/dhw22/code/index.htm
On the divergences of inflationary superhorizon perturbations
We discuss the infrared divergences that appear to plague cosmological
perturbation theory. We show that within the stochastic framework they are
regulated by eternal inflation so that the theory predicts finite fluctuations.
Using the formalism to one loop, we demonstrate that the infrared
modes can be absorbed into additive constants and the coefficients of the
diagrammatic expansion for the connected parts of two and three-point functions
of the curvature perturbation. As a result, the use of any infrared cutoff
below the scale of eternal inflation is permitted, provided that the background
fields are appropriately redefined. The natural choice for the infrared cutoff
would of course be the present horizon; other choices manifest themselves in
the running of the correlators. We also demonstrate that it is possible to
define observables that are renormalization group invariant. As an example, we
derive a non-perturbative, infrared finite and renormalization point
independent relation between the two-point correlators of the curvature
perturbation for the case of the free single field.Comment: 12 page
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