4,146 research outputs found
Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16.
In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18
A model for the generic alpha relaxation of viscous liquids
Dielectric measurements on molecular liquids just above the glass transition
indicate that alpha relaxation is characterized by a generic high-frequency
loss varying as , whereas deviations from this come from one or
more low-lying beta processes [Olsen et al, Phys. Rev. Lett. {\bf 86} (2001)
1271]. Assuming that long-wavelength fluctuations dominate the dynamics, a
model for the dielectric alpha relaxation based on the simplest coupling
between the density and dipole density fields is proposed here. The model,
which is solved in second order perturbation theory in the Gaussian
approximation, reproduces the generic features of alpha relaxation
Solidity of viscous liquids. IV. Density fluctuations
This paper is the fourth in a series exploring the physical consequences of
the solidity of highly viscous liquids. It is argued that the two basic
characteristics of a flow event (a jump between two energy minima in
configuration space) are the local density change and the sum of all particle
displacements. Based on this it is proposed that density fluctuations are
described by a time-dependent Ginzburg-Landau equation with rates in k-space of
the form with where is the average
intermolecular distance. The inequality expresses a long-wavelength dominance
of the dynamics which implies that the Hamiltonian (free energy) may be taken
to be ultra local. As an illustration of the theory the case with the simplest
non-trivial Hamiltonian is solved to second order in the Gaussian
approximation, where it predicts an asymmetric frequency dependence of the
isothermal bulk modulus with Debye behavior at low frequencies and an
decay of the loss at high frequencies. Finally, a general
formalism for the description of viscous liquid dynamics, which supplements the
density dynamics by including stress fields, a potential energy field, and
molecular orientational fields, is proposed
Magic wavelengths for the transition in rubidium
Magic wavelengths, for which there is no differential ac Stark shift for the
ground and excited state of the atom, allow trapping of excited Rydberg atoms
without broadening the optical transition. This is an important tool for
implementing quantum gates and other quantum information protocols with Rydberg
atoms, and reliable theoretical methods to find such magic wavelengths are thus
extremely useful. We use a high-precision all-order method to calculate magic
wavelengths for the transition of rubidium, and compare the
calculation to experiment by measuring the light shift for atoms held in an
optical dipole trap at a range of wavelengths near a calculated magic value
Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors
The NMDA type of ligand-gated glutamate receptor requires the presence of both glutamate and glycine for gating. These receptors are hetero-oligomers of NR1 and NR2 subunits. Previously it was thought that the binding sites for glycine and glutamate were formed by residues on the NR1 subunit. Indeed, it has been shown that the effects of glycine are controlled by residues on the NR1 subunit, and a “Venus flytrap” model for the glycine binding site has been suggested by analogy with bacterial periplasmic amino acid binding proteins. By analysis of 10 mutant NMDA receptors, we now show that residues on the NR2A subunit control glutamate potency in recombinant NR1/NR2A receptors, without affecting glycine potency. Furthermore, we provide evidence that, at least for some mutated residues, the reduced potency of glutamate cannot be explained by alteration of gating but has to be caused primarily by impairing the binding of the agonist to the resting state of the receptor. One NR2A mutant, NR2A(T671A), had anEC50for glutamate 1000-fold greater than wild type and a 255-fold reduced affinity for APV, yet it had single-channel openings very similar to those of wild type. Therefore we propose that the glutamate binding site is located on NR2 subunits and (taking our data together with previous work) is not on the NR1 subunit. Our data further imply that each NMDA receptor subunit possesses a binding site for an agonist (glutamate or glycine).</jats:p
Solidity of Viscous Liquids
Recent NMR experiments on supercooled toluene and glycerol by Hinze and
Bohmer show that small rotation angles dominate with only few large molecular
rotations. These results are here interpreted by assuming that viscous liquids
are solid-like on short length scales. A characteristic length, the "solidity
length", separates solid-like behavior from liquid-like behavior.Comment: Plain RevTex file, no figure
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