Histamine and Tyramine Content of South African Wine

The histamine content of 184 wines and tyramine content of 156 wines, produced in South Africa was measured. The histamine and tyramine content of the wine was found to be similar to those of wines produced in other countries. The average histamine content of South African red wines that had undergone malo-lactic fermentation was more than double that of red wines that had not undergone malo-lactic fermentation. All the red wines containing relatively large amounts of histamine had pH's above 3, 7. Six selected strains of malo-lactic bacteria were tested for their ability to form histamine and tyramine in white and red wine. No histamine or tyramine was formed

The Development of Alcoholic Fermented Beverages Utilizing Plums with the Application of Innovative Beverage Fermentation Technology

The adaptation of existing technologies toward producing a white wine style alcoholic fermented plum beverage was undertaken. The Independent Variables (ID) were yeast strains (Saccharomyces cerevisiae VIN13 and Saccharomyces bayanus N96), with formulations containing various percentage pulp concentrations at (40%, 50% and 60%). The Dependent Variables (DV) constituted key quality parameters for white wines, namely %methanol, %ethanol, titratable acidity (TA), objective colour, total soluble solids (TDS), pH and sensory profile were measured. %Methanol was not detected in the samples, %ethanol, TA, colour, TDS and pH were within the range typical for white wine. The overall sensorial profile of the beverage samples, fruity aroma and sweet associated aroma were rated significantly higher as the pulp concentration increased from 40% to 50% (p < 0.05). Exhibiting comparable sensory attributes namely fruity aroma, sweet-associated aroma, yeasty aroma, sweet taste, sour taste, bitter taste, astringency and fruity flavour, that was typically associated with white wines (Sokolowsky et al., 2015). The results showed that existing technology can be adapted to produce an alcoholic fermented plum beverage of which the key quality parameters and attributes are comparable to white wines

The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer

Background: Tumour budding has been reported to reflect invasiveness, metastasis and unfavourable prognosis in colorectal cancer. The aim of the study was to examine the relationship between tumour budding and clinicopathological characteristics, tumour microenvironment and survival in patients with primary operable colorectal cancer. Methods: A total of 303 patients from a prospective data set of patients with primary operable colorectal cancer were included in the study. The presence of budding was determined through assessment of all tumour-containing H&E slides and the number of tumour buds was counted using a 10 high-powered field method. Routine pathologic sections were used to assess: tumour necrosis, the tumour inflammatory cell infiltrate using Klintrup–Makinen (KM) grade and tumour stroma percentage (TSP) combined as the Glasgow Microenvironment Score (GMS). Results: High-grade tumour budding was present in 39% of all tumours and in 28% of node-negative tumours respectively. High-grade budding was significantly associated with T stage (P<0.001), N stage (P<0.001), TNM stage (P<0.001), serosal involvement (P<0.001), venous invasion (P<0.005), KM grade (P=0.022), high tumour stroma (P<0.001) and GMS (P<0.001). Tumour budding was associated with reduced cancer-specific survival (CSS) (HR=4.03; 95% confidence interval (CI), 2.50–6.52; P<0.001), independent of age (HR=1.47; 95% CI, 1.13–1.90; P=0.004), TNM stage (HR=1.52; 95% CI, 1.02–2.25; P=0.040), venous invasion (HR=1.73; 95% CI, 1.13–2.64; P=0.012) and GMS (HR=1.54; 95% CI, 1.15–2.07; P=0.004). Conclusions: The presence of tumour budding was associated with elements of the tumour microenvironment and was an independent adverse prognostic factor in patients with primary operable colorectal cancer. Specifically high tumour budding stratifies effectively the prognostic value of tumour stage, venous invasion and GMS. Taken together, tumour budding should be assessed routinely in patients with primary operable colorectal cancer

Ambulatory blood pressure monitoring - comparison with office blood pressure in patients on antihypertensive therapy in private practice

Introduction. Available data on the use of 24-hour ambulatory blood pressure recordings in private practice are limited. For this purpose we studied 39 consecutive hypertensive patients on treatment in a private practice.Method. Office blood pressure, 24-hour ambulatory blood pressure, daytime ambulatory blood pressure and M-mode echocardiography were undertaken in 39 consecutive hypertensive patients (21 men, 18 women) on treatment.Results. Mean 24-hour ambulatory blood pressure and mean daytime ambulatory blood pressure were lower than office blood pressure, similar to findings seen in academic settings. A blood pressure load of more than 50% was seen in 12 out of 39 patients (31 %). Left ventricular hypertrophy, assessed by means of Framingham criteria, was seen in 33% of patients. A white-coat effect was seen in 15.4% of patients.Conclusions. A large proportion (33%) of patients on treatment for hypertension had left ventricular hypertrophy, despite normal electrocardiograms. Ambulatory blood pressure measurements identified a blood pressure load of more than 50% in 31 % of patients on treatment for hypertension

Francois Jacobus van Zyl, hoogleraar 1960-1978

Francois Jacobus van Zyl, professor 1960-1978Professor Francois Jacobus van Zyl (6th May 1913-) served as head of the Department of Science of Religion and Missiology, Faculty of Theology (Sec A),University of Pretoria, during the period 1960-1978. This article (compiled from two previously published articles) contains a short biography, a discussion of hisviews on theology, Science of Religion, Philosophy of Religion, and Missiology. He is portrayed as a theologian with Barthian convictions. He worked from a broad theological base which can be described as ‘theology of the Word’. His primary audience was the Nederduitsch Hervormde Kerk and his theological activities(especially in the period 1960-1983) must be seen in relation to his influential role in the same church

Maternal and foetal outcomes among 4118 women with HIV infection treated with lopinavir/ritonavir during pregnancy: analysis of population-based surveillance data from the national study of HIV in pregnancy and childhood in the United Kingdom and Ireland

BACKGROUND: The National Study of HIV in Pregnancy and Childhood (NSHPC) conducts comprehensive population-based surveillance of pregnancies in women with HIV infection in the United Kingdom/Ireland. Use of antepartum antiretroviral therapy (ART) for prevention of mother-to-child transmission (MTCT) and to treat maternal infection, if required, is standard practise in this population; lopinavir/ritonavir (LPV/r) is commonly used. The study objective was to examine the use of LPV/r among pregnant women with HIV infection to describe maternal and foetal outcomes. METHODS: The NSHPC study collected maternal, perinatal and paediatric data through confidential and voluntary obstetric and paediatric reporting schemes. Pregnancies reported to the NSHPC by June 2013, due to deliver 2003-2012 and with LPV/r exposure were included in this analysis, using pregnancy as the unit of observation. RESULTS: Four thousand eight hundred sixty-four LPV/r-exposed pregnancies resulting in 4702 deliveries in 4118 women were identified. Maternal region of birth was primarily sub-Saharan Africa (77 %) or United Kingdom/Ireland (14 %). Median maternal age at conception was 30 years. LPV/r was initiated preconception in 980 (20 %) and postconception in 3884 (80 %) pregnancies; median duration of antepartum LPV/r exposure was 270 and 107 days, respectively. Viral load close to delivery was <50 copies/mL in 73 % and <1000 copies/mL in 94 % of women. 63 % of deliveries were by caesarean section (elective, 62 %; emergency, 38 %). Among singleton live births, 13 % were <37 weeks of gestation (2.5 % <32 weeks) and 15 % had birth weight <2500 g (2.3 % <1500 g). MTCT rates were 1.1 (2003-2007) and 0.5 % (2008-2012). 134 live born children (2.9 %) had ≥1 congenital abnormality. CONCLUSIONS: The results of this analysis using real-world data from a large number of pregnant women with HIV infection in the United Kingdom and Ireland who received LPV/r-containing ART regimens demonstrate that these regimens have a good safety profile and are effective for viral suppression during pregnancy, with associated low rates of MTCT

Neutron activation and high resolution gamma spectrometry - activation analysis

KI

Symmetry breaking in MAST plasma turbulence due to toroidal flow shear

The flow shear associated with the differential toroidal rotation of tokamak plasmas breaks an underlying symmetry of the turbulent fluctuations imposed by the up-down symmetry of the magnetic equilibrium. Using experimental Beam-Emission-Spectroscopy (BES) measurements and gyrokinetic simulations, this symmetry breaking in ion-scale turbulence in MAST is shown to manifest itself as a tilt of the spatial correlation function and a finite skew in the distribution of the fluctuating density field. The tilt is a statistical expression of the "shearing" of the turbulent structures by the mean flow. The skewness of the distribution is related to the emergence of long-lived density structures in sheared, near-marginal plasma turbulence. The extent to which these effects are pronounced is argued (with the aid of the simulations) to depend on the distance from the nonlinear stability threshold. Away from the threshold, the symmetry is effectively restored

Some Volatile Aroma Components of Vitis Vinifera L. cv. Sauvignon blanc

Volatile aroma components of Vitis vinifera L. cv. Sauvignon blanc grapes were studied to identify the components responsible for the characteristic aroma of this grape cultivar. Thirty three volatile components were identified. Amongst these methional and trans-2, cis-6-nonadienal are reported present in Vitis for the first time. Evidence is also presented for the presence of three methoxypyrazines which are believed to be key substances responsible for the typical aroma present in grapes and wines of this cultivar

Chenin blanc Wine Volatiles and the Intensity of a Guava-like Flavour

A guava-like flavour occurring in some South African Chenin blanc and Colombard dry white wines was investigated. Headspace volatiles of some of these wines, as well as those of fresh guava fruits, were analysed by means of a gas chromatograph equipped with a "sniffer-detector". In contrast to the headspace concentrate of guava fruits, no single fraction with a typical guava flavour was found in the wines analysed. The pattern recognition system "ARTHUR" was therefore used to investigate relationships between the more important wine volatiles and the intensity of a guava-like flavour of a set of wines originating from the same Chenin blanc must. Sensory scores for this flavour were used in both category and continuous property analysis in each case. Category and correlation to property plots were used to elucidate the results. Several promising variables and ratios between variables were singled out for further investigation, notably ethyl butyrate and the ratios ethyl butyrate/ethyl decanoate and ethyl butyrate/ethyl octanoate