High Power RF Induced Thermal Fatigue in the High Gradient CLIC Accelerating Structures

The need for high accelerating gradients for the CLIC (Compact Linear Collider) imposes considerable constraints on the materials of the accelerating structures. The surfaces exposed to high pulsed RF (Radio Frequency) currents are subjected to cyclic thermal stresses possibly resulting in surface break up by fatigue. Various high strength alloys from the group of high conductivity copper alloys have been selected and have been tested in different states, with different surface treatments and in different stress ratios. Low to medium cycle fatigue data (up to 108 cycles) of fully compressive surface thermal stresses has been collected by means of a pulsed laser surface heating apparatus. The surface damage has been characterized by SEM observations and roughness measurements. High cycle fatigue data, up to 7x1010 cycles, of varying stress ratio has been collected in high frequency bulk fatigue tests using an ultrasonic apparatus. Up-to-date results from these experiments are presented

Material Selection and Characterization for High Gradient RF Applications

The selection of candidate materials for the accelerating cavities of the Compact Linear Collider (CLIC) is carried out in parallel with high power RF testing. The maximum DC breakdown field of copper, copper alloys, refractory metals, aluminium and titanium have been measured with a dedicated setup. Higher maximum fields are obtained for refractory metals and for titanium, which exhibits, however, important damages after conditioning. Fatigue behaviour of copper alloys has been studied for surface and bulk by pulsed laser irradiation and ultrasonic excitation, respectively. The selected copper alloys show consistently higher fatigue resistance than copper in both experiments. In order to obtain the best local properties in the device a possible solution is a bi-metallic assembly. Junctions of molybdenum and copper-zirconium UNS C15000 alloy, achieved by HIP (Hot Isostatic Pressing) diffusion bonding or explosion bonding were evaluated for their mechanical strength. The reliability of the results obtained with both techniques should be improved. Testing in DC and radiofrequency (RF) is continued in order to select materials for a bi-metal exhibiting superior properties with respect to the combination C15000-Mo

Technical Specification for the CLIC Two-Beam Module

A high-energy (0.5-3 TeV centre-of-mass), highluminosity Compact Linear Collider (CLIC) is being studied at CERN [1]. The CLIC main linacs, 21-km long each, are composed of 2-m long two beam modules. This paper presents their current layout, the main requirements for the different sub-systems (alignment, supporting, stabilization, cooling and vacuum) as well as the status of their integration

SLAC/CERN high gradient tests on an X-band accelerating section

High frequency linear collider schemes envisage the use of rather high accelerating gradients: 50 to 100 MV/m for X-band and 80 MV/m for CLIC. Because these gradients are well above those commonly used in accelerators, high gradient studies of high frequency structures have been initiated and test facilities have been constructed at KEK [1], SLAC [2] and CERN [3]. The studies seek to demonstrate that the above mentioned gradients are both achievable and practical. There is no well-defined criterion for the maximum acceptable level of dark current but it must be low enough not to generate unacceptable transverse wakefields, disturb beam position monitor readings or cause RF power losses. Because there are of the order of 10,000 accelerating sections in a high frequency linear collider, the conditioning process should not be too long or difficult. The test facilities have been instrumented to allow investigation of field emission and RF breakdown mechanisms. With an understanding of these effects, the high gradient performance of accelerating sections may be improved through modifications in geometry, fabrication methods and surface finish. These high gradient test facilities also allow the ultimate performance of high frequency/short pulse length accelerating structures to be probed. This report describes the high gradient test at SLAC of an X-band accelerating section built at CERN using technology developed for CLIC

Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)

Background: In critically ill patients, tigecycline (TGC) remains an important therapeutic option due to its efficacy against multiresistant Gram-positive and Gram-negative bacteria. TGC is metabolized and eliminated predominantly by the liver. Critical illness-induced liver failure may have a profound impact on the pharmacokinetic of TGC. In the present study, we aimed to establish a link between the degree of liver dysfunction and TGC plasma concentration using the novel maximum liver function capacity (LiMAx) test, as a dynamic liver function test. Materials/methods: The prospective study included 33 patients from a surgical ICU with the clinical indication for antibiotic therapy with TGC. The patients received 100 mg loading dose of TGC followed by intermittent standard doses of 50 mg q12. Blood samples for TGC plasma concentration were collected at 0.3, 2, 5, 8 and 11.5 h in a steady-state condition after at least 36 h post-standard dosage. The results were analyzed by means of a high-performance liquid chromatography (HPLC) method. Within the same day, the LiMAx test was carried out and routine blood parameters were measured. Results: Peak plasma concentrations of TGC were significantly higher in patients with severe liver failure (LiMAx  300 µg/kg/h). The pharmacokinetic curves revealed higher values in severe liver failure at any measured point. Moreover, LiMAx and total bilirubin were the only liver-related parameters that correlated with TGC Cmax. Conclusions: The present study demonstrates a high variability of TGC plasma concentrations in critically ill patients. The results show a significant correlation between the degree of liver dysfunction, measured by the LiMAx test, and TGC Cmax. LiMAx test may be a helpful tool beyond others for adjusting the required dosage of hepatic metabolized antibiotics in critically ill patients. Trial registry DRKS—German clinical trials register; Trial registration number: DRKS00008888; Date of registration: 07-17-2015; Date of enrolment of the first participant to the trial: 12-10-201

High-Power Testing of X-Band CLIC Power Generating Structures

A fundamental element of the CLIC concept is two-beam acceleration, where rf power is extracted from a high-current and low-energy beam in order to accelerate the low-current main beam to high energy. The power extraction occurs in special Xband Power Extraction and Transfer Structures (PETS). The structures are large aperture, high-group velocity and overmoded periodic structures. Following the substantial changes of the CLIC baseline parameters in 2006, the PETS design has been thoroughly updated along with the fabrication methods and corresponding rf components. Two PETS prototypes have been fabricated and high power tested. Test results and future plans are presented