The transformation of scenery to landscape in Zuber wallpapers from a cross-cultural perspective

As a pioneering type of industrial printmaking, wallpaper is a record of the landscapes of different cities in different countries and is the focus of our inquiry into the development of cityscape art. This paper takes Zuber&Cie wallpaper as an example, firstly, it briefly describes the development of wallpaper from a mere decorative commodity to a redesigned natural landscape painting in the 19th-20th centuries, and compares the process of transformation of land to landscape in Zuber wallpaper, i.e. the transformation process of scenery to landscape, and at the same time, by analysing the selected paintings in The second is an interdisciplinary analysis of the narrative content and narrative techniques used in Zuber\u27s wallpaper painting using art historical research methods such as iconography and formal analysis. Finally, a cross-cultural perspective is adopted to examine the historical and socio-political significance behind the transformation of the landscape from a pastoral rustic to a national park and its cultural transmission and change as a result of international trade

放線菌MG-1はdTHP-1マクロファージ細胞において炎症反応を誘導する

大阪歯科大学Osaka Dental University博士（歯学）Actinomycetes, as one of the earliest colonizers in the oral environment, have been studied because previous research has found that they facilitate the colonization of other oral pathogens. Although the inflammatory responses triggered by Actinomycete in the oral cavity have not been considered very important, they may play a significant role in the progression of oral inflammatory diseases. We treated differentiated THP-1 cells (dTHP-1) transiently with Actinomyces oris (A. oris) MG-1 as an inflammatory model. We also used resveratrol, a naturally derived anti­inflammatory compound, as an inflammatory inhibitor in our model. Using CCK­8, ELISA, and western blotting to analyze the inflammatory model, we discovered that A. oris MG-1 reduced the viability of dTHP-1 cells. The secretion of IL-1β into the supernatant indicated an inflammatory response, which was further confirmed by the western blot results. We found that resveratrol has potential as an antiinflammatory intervention and is worthy of further investigation.doctoral thesi

Differentially Private Average Consensus with Improved Accuracy-Privacy Trade-off

This paper studies the average consensus problem with differential privacy of initial states, for which it is widely recognized that there is a trade-off between the mean-square computation accuracy and privacy level. Considering the trade-off gap between the average consensus algorithm and the centralized averaging approach with differential privacy, we propose a distributed shuffling mechanism based on the Paillier cryptosystem to generate correlated zero-sum randomness. By randomizing each local privacy-sensitive initial state with an i.i.d. Gaussian noise and the output of the mechanism using Gaussian noises, it is shown that the resulting average consensus algorithm can eliminate the gap in the sense that the accuracy-privacy trade-off of the centralized averaging approach with differential privacy can be almost recovered by appropriately designing the variances of the added noises. We also extend such a design framework with Gaussian noises to the one using Laplace noises, and show that the improved privacy-accuracy trade-off is preserved

Retinal OCT Synthesis with Denoising Diffusion Probabilistic Models for Layer Segmentation

Modern biomedical image analysis using deep learning often encounters the challenge of limited annotated data. To overcome this issue, deep generative models can be employed to synthesize realistic biomedical images. In this regard, we propose an image synthesis method that utilizes denoising diffusion probabilistic models (DDPMs) to automatically generate retinal optical coherence tomography (OCT) images. By providing rough layer sketches, the trained DDPMs can generate realistic circumpapillary OCT images. We further find that more accurate pseudo labels can be obtained through knowledge adaptation, which greatly benefits the segmentation task. Through this, we observe a consistent improvement in layer segmentation accuracy, which is validated using various neural networks. Furthermore, we have discovered that a layer segmentation model trained solely with synthesized images can achieve comparable results to a model trained exclusively with real images. These findings demonstrate the promising potential of DDPMs in reducing the need for manual annotations of retinal OCT images.Comment: ISBI 202

“Cultural and Creative IP” Empowerment Model for Red Culture under the New Media Environment

Boasting exemplary national qualities and high educational value, Red Culture is a unique spiritual wealth that make the Chinese nation stand out from the rest nations. Under the new media environment, however, the collision between the disparate characteristics of Red Culture and new media has given rise to the predicament plaguing the communication of Red Culture. With the advent of the 100th anniversary of the founding of the Communist Party of China, both tangible and intangible cultural heritage and resources are being valued, tapped and cultivated across the country. With the cultural and creative industry in the ascendant, the concept of intellectual property (“IP”) has seeped into all aspects of our everyday lives. Against that backdrop, this study attempts to explore novel ways to link up the Red Culture resources scattered across China, to combine education with cultural tourism through the “4+5+2” cultural and creative IP empowerment model, and to pass on and spread Red Culture and add new value to the industry on the strength of influential IPs

Electronic Delocalization Engineering of β‐AsP Enabled High‐Efficient Multisource Logic Nanodevices

Delocalized electron and phonon structures are directives for rationally tuning the intrinsic physicochemical properties of 2D materials by redistributing electronic density. However, it is still challenging to accurately manipulate the delocalized electron and systematically study the relationships between physiochemical properties and practical nanodevices. Herein, the effects of delocalized electrons engineering on blue-arsenic-phosphorus (β-AsP)-based practical devices are systematically investigated via implementing vacancies or heteroatom doping. A tendency of carrier conductivity property from “half-metal” to “metal” is initially found when tuning the electronic structure of β-AsP with adjustable vacancy concentrations below 2 at% or above 3 at%, which can be ascribed to the introduction of delocalized electrons that cause asymmetric contributions to the electronic states near the implementation site. In optical logic device simulations, broadband response, triangular wave circuit system signal, and reverse polarization anisotropy are achieved by adjusting the vacancy concentration, while extinction ratios are as high as 1561. The electric and thermic-logic devices realize the highest available reported giant magnetoresistance (MR) up to 1013% and 1039% at vacancy concentrations of 1.67% and 0.89%, respectively, which is significantly superior to the reports. The results shed light on the electronic delocalization strategy of regulating internal structures to achieve highly efficient nanodevices

Crystal Structure of the Cysteine Desulfurase DndA from Streptomyces lividans Which Is Involved in DNA Phosphorothioation

DNA phosphorothioation is widespread among prokaryotes, and might function to restrict gene transfer among different kinds of bacteria. There has been little investigation into the structural mechanism of the DNA phosphorothioation process. DndA is a cysteine desulfurase which is involved in the first step of DNA phosphorothioation. In this study, we determined the crystal structure of Streptomyces lividans DndA in complex with its covalently bound cofactor PLP, to a resolution of 2.4 Å. Our structure reveals the molecular mechanism that DndA employs to recognize its cofactor PLP, and suggests the potential binding site for the substrate L-cysteine on DndA. In contrast to previously determined structures of cysteine desulfurases, the catalytic cysteine of DndA was found to reside on a β strand. This catalytic cysteine is very far away from the presumable location of the substrate, suggesting that a conformational change of DndA is required during the catalysis process to bring the catalytic cysteine close to the substrate cysteine. Moreover, our in vitro enzymatic assay results suggested that this conformational change is unlikely to be a simple result of random thermal motion, since moving the catalytic cysteine two residues forward or backward in the primary sequence completely disabled the cysteine desulfurase activity of DndA

Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes

Explosive growth in the study of microbial epigenetics has revealed a diversity of chemical structures and biological functions of DNA modifications in restriction-modification (R-M) and basic genetic processes. Here, we describe the discovery of shared consensus sequences for two seemingly unrelated DNA modification systems, [superscript 6m]A methylation and phosphorothioation (PT), in which sulfur replaces a nonbridging oxygen in the DNA backbone. Mass spectrometric analysis of DNA from Escherichia coli B7A and Salmonella enterica serovar Cerro 87, strains possessing PT-based R-M genes, revealed d(G[subscript PS] [superscript 6m]A) dinucleotides in the G[subscript PS] [superscript 6m]AAC consensus representing ∼5% of the 1,100 to 1,300 PT-modified d(G[subscript PS] A) motifs per genome, with [superscript 6m]A arising from a yet-to-be-identified methyltransferase. To further explore PT and 6m A in another consensus sequence, G[subscript PS] [superscript 6m]ATC, we engineered a strain of E. coli HST04 to express Dnd genes from Hahella chejuensis KCTC2396 (PT in G[subscript PS] ATC) and Dam methyltransferase from E. coli DH10B ( [superscript 6m] A in G [superscript 6m] ATC). Based on this model, in vitro studies revealed reduced Dam activity in G PS ATC-containing oligonucleotides whereas single-molecule real-time sequencing of HST04 DNA revealed [superscript 6m] A in all 2,058 G[subscript PS] ATC sites (5% of 37,698 total GATC sites). This model system also revealed temperature-sensitive restriction by DndFGH in KCTC2396 and B7A, which was exploited to discover that [superscript 6m] A can substitute for PT to confer resistance to restriction by the DndFGH system. These results point to complex but unappreciated interactions between DNA modification systems and raise the possibility of coevolution of interacting systems to facilitate the function of each