Study on the radiative decays of hch_c via intermediate meson loops model

Recently, the BESIII Collaboration reported two new decay processes $h_c(1P)\to \gamma \eta$ and $\gamma \eta^\prime$. Inspired by this measurement, we propose to study the radiative decays of $h_c$ via intermediate charmed meson loops in an effective Lagrangian approach. With the acceptable cutoff parameter range, the calculated branching ratios of $h_c(1P)\to \gamma \eta$ and $\gamma \eta^\prime$ are orders of $10^{-4}\sim 10^{-3}$ and $10^{-3} \sim 10^{-2}$, respectively. The ratio $R_{h_c}= \mathcal{B}( h_c\to \gamma \eta )/\mathcal{B}( h_c\to \gamma \eta^\prime )$ can reproduce the experimental measurements with the commonly acceptable $\alpha$ range. This ratio provide us some information on the $\eta-\eta^\prime$ mixing, which may be helpful for us to test SU(3)-flavor symmetries in QCD.Comment: 11 pages, 5 figures, accepted for publication in EPJ

Activation domains can decouple the mean and noise of gene expression

Regulatory mechanisms set a gene\u27s average level of expression, but a gene\u27s expression constantly fluctuates around that average. These stochastic fluctuations, or expression noise, play a role in cell-fate transitions, bet hedging in microbes, and the development of chemotherapeutic resistance in cancer. An outstanding question is what regulatory mechanisms contribute to noise. Here, we demonstrate that, for a fixed mean level of expression, strong activation domains (ADs) at low abundance produce high expression noise, while weak ADs at high abundance generate lower expression noise. We conclude that differences in noise can be explained by the interplay between a TF\u27s nuclear concentration and the strength of its AD\u27s effect on mean expression, without invoking differences between classes of ADs. These results raise the possibility of engineering gene expression noise independently of mean levels in synthetic biology contexts and provide a potential mechanism for natural selection to tune the noisiness of gene expression

Production of X

We investigate the production of Xb in the process Υ(5S,6S)→γXb, where Xb is assumed to be the counterpart of X(3872) in the bottomonium sector as BB¯⁎ molecular state. We use the effective Lagrangian based on the heavy quark symmetry to explore the rescattering mechanism and calculate their production ratios. Our results have shown that the production ratios for Υ(5S,6S)→γXb are orders of 10-5 with reasonable cutoff parameter range α≃2~3. The sizeable production ratios may be accessible at the future experiments like forthcoming BelleII, which will provide important clues to the inner structures of the exotic state Xb

Study of PBLH and Its Correlation with Particulate Matter from One-Year Observation over Nanjing, Southeast China

The Planetary Boundary Layer Height (PBLH) plays an important role in the formation and development of air pollution events. Particulate Matter is one of major pollutants in China. Here, we present the characteristics of PBLH through three-methods of Lidar data inversion and show the correlation between the PBLH and the PM2.5 (PM2.5 with the diameter 75 μg/m3 and the PM2.5 \u3c 35 μg/m3 in daytime, respectively. The low PBLH often occurs with condition of the low wind speed and high relative humidity, which will lead to high PM2.5 concentration and the low visibility. On the other hand, the stability of PBL is enhanced by high PM concentration and low visibility

Exploring the mechanisms under Zuogui Pill’s treatment of ischemic stroke through network pharmacology and in vitro experimental verification

Due to its high mortality, incidence and disability rates, ischemic stroke poses heavy economic burdens to families and society. Zuogui Pill (ZGP) is a classic Chinese medicine for tonifying the kidney, which is effective for the recovery of neurological function after ischemic stroke. However, Zuogui Pill has not been evaluated for its potential effects on ischemic strokes. Using network pharmacology, the research aimed to explore the mechanisms of Zuogui Pill on ischemic stroke, which were further validated in SH-SY5Y cells injured by oxygen and glucose deprivation/reperfusion (OGD/R). Network analysis of Zuogui Pill identified 86 active ingredients and 107 compound-related targets correlated with ischemic stroke. Additionally, 11 core active compounds were obtained, such as Quercetin, beta sitosterol, and stigmasterol. Most of the compounds have been proven to have pharmacological activities. Based on pathway enrichment studies, Zuogui Pill may exert neuroprotection through MAPK signaling, PI3K-Akt signaling and apoptosis, as well as enhance neurite outgrowth and axonal regeneration effect via mTOR signaling, p53 signaling and Wnt signaling pathways. In vitro experiment, the viability of ischemic neuron treated with Zuogui Pill was increased, and the ability of neurite outgrowth was significantly improved. Western blot assays shown that the pro-neurite outgrowth effect of Zuogui Pill on ischemic stroke may be relate to PTEN/mTOR signal pathway. The results of the study provided new insights into Zuogui Pill’s molecular mechanism in treatment of ischemic stroke, as well as clinical references for its use

Ecological stoichiometry and homeostasis characteristics of plant-litter-soil system with vegetation restoration of the karst desertification control

It is of great significance to clarify the ecologically chemical stoichiometric characteristics of plant-litter-soil in vegetation restoration process for elucidating the nutrient cycling law and soil nutrient management of karst ecosystem. The carbon (C), nitrogen (N) and phosphorus (P) contents of leaves, litter and soil and their stoichiometry were determined in loquat (Eribotrya japonica) plantations in a karst plateau canyon after 3, 6, 10 and 15 years of restoration. The homeostasis characteristics of leaf N, P, and N:P with the change in soil nutrients during restoration were revealed. The results showed that leaf C, N, and P contents initially increased and then decreased with increasing years of restoration at the same sampling time. The contents of nutrients in soil and litter varied with increasing restoration years, with the highest values mostly appearing in May and July. This could be due to greater moisture in May and July, which helps with nutrient absorption and transformation. The leaf N:P ratio of loquat with different restoration years was 35.76-47.39, with an average of 40.06. Therefore, loquat leaves may experience P limitation in the growth process. The relationships between N, P and N:P in leaves and soil indexes could be simulated by a homeostasis model. Except for the weak sensitivity of loquat leaf N in 10 years, the other indexes and treatments had a certain homeostasis. Plants maintain homeostasis by regulating physiological responses in vivo in response to soil nutrient changes, indicating that loquat has good adaptability in karst desertification environments, but attention should focus on the management of soil P in the field as part of the vegetation restoration process. Therefore, in future research, we should combine the soil water and fertilizer conditions of different growing seasons in karst rocky desertification areas and provide scientific field management to ensure that the results of rocky desertification management can play a role in rural revitalization