Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano-Bio-Platforms

Engineering advanced therapeutic and diagnostic nano-bio-platforms (NBPFs) have emerged as rapidly-developed pathways against a wide range of challenges in antitumor, antipathogen, tissue regeneration, bioimaging, and biosensing applications. Emerged 2D materials have attracted extensive scientific interest as fundamental building blocks or nanostructures among material scientists, chemists, biologists, and doctors due to their advantageous physicochemical and biological properties. This timely review provides a comprehensive summary of creating advanced NBPFs via emerging 2D materials (2D-NBPFs) with unique insights into the corresponding molecularly restructured microenvironments and biofunctionalities. First, it is focused on an up-to-date overview of the synthetic strategies for designing 2D-NBPFs with a cross-comparison of their advantages and disadvantages. After that, the recent key achievements are summarized in tuning the biofunctionalities of 2D-NBPFs via molecularly programmed microenvironments, including physiological stability, biocompatibility, bio-adhesiveness, specific binding to pathogens, broad-spectrum pathogen inhibitors, stimuli-responsive systems, and enzyme-mimetics. Moreover, the representative therapeutic and diagnostic applications of 2D-NBPFs are also discussed with detailed disclosure of their critical design principles and parameters. Finally, current challenges and future research directions are also discussed. Overall, this review will provide cutting-edge and multidisciplinary guidance for accelerating future developments and therapeutic/diagnostic applications of 2D-NBPFs

Characterization of loss mechanisms in a fluxonium qubit

Using a fluxonium qubit with in situ tunability of its Josephson energy, we characterize its energy relaxation at different flux biases as well as different Josephson energy values. The relaxation rate at qubit energy values, ranging more than one order of magnitude around the thermal energy $k_B T$, can be quantitatively explained by a combination of dielectric loss and $1/f$ flux noise with a crossover point. The amplitude of the $1/f$ flux noise is consistent with that extracted from the qubit dephasing measurements at the flux sensitive points. In the dielectric loss dominant regime, the loss is consistent with that arises from the electric dipole interaction with two-level-system (TLS) defects. In particular, as increasing Josephson energy thus decreasing qubit frequency at the flux insensitive spot, we find that the qubit exhibits increasingly weaker coupling to TLS defects thus desirable for high-fidelity quantum operations

Analysis of the joint detection capability of the SMILE satellite and EISCAT-3D radar

The Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) satellite is a small magnetosphere–ionosphere link explorer developed cooperatively between China and Europe. It pioneers the use of X-ray imaging technology to perform large-scale imaging of the Earth’s magnetosheath and polar cusp regions. It uses a high-precision ultraviolet imager to image the overall configuration of the aurora and monitor changes in the source of solar wind in real time, using in situ detection instruments to improve human understanding of the relationship between solar activity and changes in the Earth’s magnetic field. The SMILE satellite is scheduled to launch in 2025. The European Incoherent Scatter Sciences Association (EISCAT)-3D radar is a new generation of European incoherent scatter radar constructed by EISCAT and is the most advanced ground-based ionospheric experimental device in the high-latitude polar region. It has multibeam and multidirectional quasi-real-time three-dimensional (3D) imaging capabilities, continuous monitoring and operation capabilities, and multiple-baseline interferometry capabilities. Joint detection by the SMILE satellite and the EISCAT-3D radar is of great significance for revealing the coupling process of the solar wind–magnetosphere–ionosphere. Therefore, we performed an analysis of the joint detection capability of the SMILE satellite and EISCAT-3D, analyzed the period during which the two can perform joint detection, and defined the key scientific problems that can be solved by joint detection. In addition, we developed Web-based software to search for and visualize the joint detection period of the SMILE satellite and EISCAT-3D radar, which lays the foundation for subsequent joint detection experiments and scientific research

Analysis of risk factors and short-term prognostic factors of arrhythmia in patients infected with mild/moderate SARS-CoV-2 Omicron variant

BackgroundComplications, including arrhythmia, following severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection continue to be of concern. Omicron is the mainstream SARS-CoV-2 mutant circulating in mainland China. At present, there are few epidemiological studies concerning the relationship between arrhythmia and Omicron variant infection in mainland China.ObjectivesTo investigate the risk factors of arrhythmia in patients infected with the SARS-CoV-2 Omicron variant and the factors influencing prognosis.MethodsData from 192 Omicron infected patients with symptoms of arrhythmia (AH group) and 100 Omicron infected patients without arrhythmia (Control group) were collected. Patients in the AH group were divided into the good and poor prognosis groups, according to the follow-up results 4–6 weeks after infection. The general and clinical data between the AH and Control groups, and between the good and poor prognosis groups were compared. The variables with differences between the groups were included in the multivariate logistic regression analysis, and the quantitative variables were analyzed by receiver operating characteristic curve to obtain their cut-off values.ResultsCompared with the control group, the body mass index (BMI), proportion of patients with a history of arrhythmia, proportion of antibiotics taken, heart rate, moderate disease severity, white blood cell (WBC) count, and the aspartate aminotransferase, creatine kinase (CK), CK isoenzyme (CK-MB), myoglobin (Mb), high-sensitive troponin I (hs-cTnI), lymphocyte ratio and high sensitivity C-reactive protein (hs-CRP) levels in the AH group were significantly higher (p < 0.05). In addition, obesity (BMI ≥24 kg/m2), fast heart rate (≥100 times/min), moderate disease severity, and WBC, CK-MB and hs-cTnI levels were independent risk factors of arrhythmia for patients with Omicron infection (p < 0.05), and hs-CRP was a protective factor (p < 0.05). Compared with the good prognosis group, the age, proportion of patients with a history of arrhythmia, heart rate, proportion of moderate disease severity, and hs-CRP, CK, Mb and hs-cTnI levels were significantly higher in the poor prognosis group, while the proportion of vaccination was lower in the poor prognosis group (p < 0.05). Advanced age (≥65 years old), proportion of history of arrhythmia, moderate disease severity, vaccination, and hs-CRP, Mb and cTnI levels were independent factors for poor prognosis of patients with arrhythmia (p < 0.05).ConclusionThe factors that affect arrhythmia and the prognosis of patients infected with Omicron include obesity, high heart rate, severity of the disease, age. history of arrhythmia, WBC, hs-CRP, and myocardial injury indexes, which could be used to evaluate and prevent arrhythmia complications in patients in the future

Titanium Nitride Film on Sapphire Substrate with Low Dielectric Loss for Superconducting Qubits

Dielectric loss is one of the major decoherence sources of superconducting qubits. Contemporary high-coherence superconducting qubits are formed by material systems mostly consisting of superconducting films on substrate with low dielectric loss, where the loss mainly originates from the surfaces and interfaces. Among the multiple candidates for material systems, a combination of titanium nitride (TiN) film and sapphire substrate has good potential because of its chemical stability against oxidization, and high quality at interfaces. In this work, we report a TiN film deposited onto sapphire substrate achieving low dielectric loss at the material interface. Through the systematic characterizations of a series of transmon qubits fabricated with identical batches of TiN base layers, but different geometries of qubit shunting capacitors with various participation ratios of the material interface, we quantitatively extract the loss tangent value at the substrate-metal interface smaller than $8.9 \times 10^{-4}$ in 1-nm disordered layer. By optimizing the interface participation ratio of the transmon qubit, we reproducibly achieve qubit lifetimes of up to 300 $\mu$s and quality factors approaching 8 million. We demonstrate that TiN film on sapphire substrate is an ideal material system for high-coherence superconducting qubits. Our analyses further suggest that the interface dielectric loss around the Josephson junction part of the circuit could be the dominant limitation of lifetimes for state-of-the-art transmon qubits

Social Support and Drug Abstention Motivation among Chinese Male Drug Addicts: A Moderated Mediation Model of Self-Control and Sensation-Seeking

The goal of this study is to examine how social support affects Chinese male drug addicts’ abstention motivation. To elucidate the mechanism as well as the boundary condition of the aforesaid influence, self-control and sensation-seeking were induced. Using the questionnaire method, the cross-sectional data were collected from 498 male drug addicts from one hospital and four compulsory isolation drug abstention centers in Central China region. The results indicated that social support has a positive direct and indirect effect on abstention motivation. The indirect influence is that the impact of social support on abstention motivation is mediated by self-control. The direct effect was moderated by sensation-seeking. Specifically, for individuals with low sensation-seeking, social support can significantly increase drug abstinence motivation, but this effect was not significant for those with high sensation-seeking. Theoretical and practical implications of the results were discussed

Linking Cognitive Reappraisal and Expressive Suppression to Mindfulness: A Three-Level Meta-Analysis

Cognitive reappraisal and expressive suppression have long been considered the two most important emotion regulation strategies. Increasingly, studies have found that mindfulness has a relationship with them. However, the magnitude and direction of the relationship between them have yet to reach a consistent conclusion. To this end, a three-level meta-analysis was used to explore the relationship between mindfulness, cognitive reappraisal, and expressive suppression. Thirty-six studies were included in the meta-analysis through a literature search, including 36 samples with 83 effect sizes and a total of 12,026 subjects. The three-level random effects model showed that mindfulness was positively correlated with cognitive reappraisal to a low to moderate degree but was not correlated with expressive suppression. The moderating effect analysis showed that the relationship between mindfulness and cognitive reappraisal was slightly closer in males than in females. The study found a relatively stable positive relationship between mindfulness and cognitive reappraisal, an adaptive emotion regulation mode, while the relationship with expressive suppression was insignificant. The finding supported the affect regulation training model and also shed light on potential areas for future studies

Authenticity Mediates the Relationship between Risk Perception of COVID-19 and Subjective Well-Being: A Daily Diary Study

The present research investigated whether risk perception of COVID-19 relates to subjective well-being and the mediating role of authenticity in this association. We conducted a 12-day daily diary study with 133 undergraduates (Mage = 19.9 years, SD = 1.27 years; 64 females). Participants self-reported risk perception of COVID-19, authenticity, and subjective well-being every day. Results revealed that (1) risk perception of COVID-19 was negatively related to subjective well-being at the interindividual level; (2) authenticity mediated the relationship between risk perception of COVID-19 and subjective well-being at the interindividual level but not at the intraindividual level. In general, findings suggested that risk perception of COVID-19 is negatively related to subjective well-being only at the interindividual level, and authenticity plays a mediating role in this relationship. The finding suggested that keeping authenticity is a good strategy for avoiding the disruption caused by COVID-19. Longitudinal studies on samples with a broader age range, larger sample size, and extended sociodemographic background, as well as experimental studies, should be conducted to explore the causal relationship among interested variables that the current research has not detected

Low charge overpotentials in lithium–oxygen batteries based on tetraglyme electrolytes with a limited amount of water

High charge overpotentials are a great challenge for the realization of lithium–oxygen batteries. Here, we construct a Li–O2 battery system by introducing a limited amount of water into tetraglyme based electrolytes and electrolytic MnO2 (EMD) and Ru supported on Super P as cathodes for Li–O2 batteries. This results in low charge potentials of around 3.2 V, corresponding to overpotentials of 0.24 V, and outstanding rate capability and cycling performance