Di-μ-chlorido-bis­[(2′-carb­oxybiphen­yl-2-carboxyl­ato-κO)(2,2′:6′,2′′-terpyridine-κ3 N,N′,N′′)cadmium(II)] hemihydrate

In the centrosymmetric dinuclear title compound, [Cd2(C14H9O4)2Cl2(C15H11N3)2]·0.5H2O, each of the CdII ions is coordinated by three N atoms from a chelating 2,2′:6′,2′′-terpyridine ligand, two bridging Cl atoms and one O atom of a 2′-carb­oxy-[1,1′-biphen­yl]-2-carboxyl­ate anion. The coordination environment is distorted octa­hedral. In the crystal, inter­molecular O—H⋯O hydrogen bonds link symmetry-related mol­ecules, forming an infinite chain. The half-occupancy water mol­ecule is disordered over two general sites with 0.25 occupancy and is, in turn, disordered over an inversion center

Discovery of six high-redshift quasars with the Lijiang 2.4m telescope and the Multiple Mirror Telescope

Quasars with redshifts greater than 4 are rare, and can be used to probe the structure and evolution of the early universe. Here we report the discovery of six new quasars with $i$-band magnitudes brighter than 19.5 and redshifts between 2.4 and 4.6 from the YFOSC spectroscopy of the Lijiang 2.4m telescope in February, 2012. These quasars are in the list of $z>3.6$ quasar candidates selected by using our proposed $J-K/i-Y$ criterion and the photometric redshift estimations from the SDSS optical and UKIDSS near-IR photometric data. Nine candidates were observed by YFOSC, and five among six new quasars were identified as $z>3.6$ quasars. One of the other three objects was identified as a star and the other two were unidentified due to the lower signal-to-noise ratio of their spectra. This is the first time that $z>4$ quasars have been discovered using a telescope in China. Thanks to the Chinese Telescope Access Program (TAP), the redshift of 4.6 for one of these quasars was confirmed by the Multiple Mirror Telescope (MMT) Red Channel spectroscopy. The continuum and emission line properties of these six quasars, as well as their central black hole masses and Eddington ratios, were obtained.Comment: 7 pages, 2 figures, published in Research in Astronomy and Astrophysics (RAA) as a lette

Obesity and Heart Diseases, a Worsened Epidemic in Recent Decades

Overweight and obesity are major risk factors for a number of chronic diseases, including diabetes, cardiovascular diseases and metabolic diseases. Obesity induces serious heart diseases such as hypertension, heart failure, and coronary disease by multiple mechanisms. The endothelial dysfunction and artherosclerosis induced by obesity lead to the result of coronary artery disease. In addition, obesity is a substantial public health crisis worldwide, and internationally, with the prevalence increasing rapidly in numerous industrialized nations. Worldwide, 39% of adults aged 18 years and over were overweight in 2014, and 13% were obese. The first choice of treatment is weight loss by life-style modification, such as diet and exercise. Medication and surgery are for moderate obese patients with comorbidity. How to find the appropriate method of weight losing is the most important issue

优质护理服务对骨科空巢患者心理障碍的应用效果

Objective: To investigate the effect of high quality nursing service in empty-nest patients of psychological barriers among orthopedic ward. Methods: 60 empty-nester patients were chosen from orthopedic ward, 30 patients treated with high quality care demonstration were the observation group and 30 patients treated with conventional care demonstration were the control group, 30 patients in control group were given the conventional nursing methods during hospitalization, observation group given the high quality nursing service, observe the nursing satisfaction in two groups. Results: Observation group nursing care and nurses job satisfaction are higher than the control group and the depression, psychological mood of anxiety in observation patients are lower than the control group，the difference was statistically significant (P<0.05). Conclusion: Using the high quality nursing service in empty-nest patients among orthopedic ward, could effectively relieve patients' anxiety and other negative emotions, improve patients care satisfaction experience of nursing care and nurses job satisfaction, help to promote the high quality nursing service demonstration project. 目的  探讨骨科空巢患者住院期间采取优质护理服务的应用效果。方法  选取60例骨科住院空巢患者，骨科优质护理示范病房收治的30例空巢患者为观察组，骨科非优质护理示范病房收治的30例空巢患者为对照组，对照组在住院期间给予常规护理方法，观察组在此基础上采用优质护理服务，观察两组护理满意度。结果  观察组的患者对护理工作满意度高于对照组，观察组空巢患者抑郁、焦虑的心理情绪低于对照组，观察组护士职业满意度高于对照组，差异有统计学意义（P<0.05）。结论  对骨科住院空巢焦虑患者采用优质护理服务，可有效减轻患者焦虑等负性情绪，

Inflammasomes and Fibrosis

Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors. There are four main members of the inflammasomes, such as NOD-like receptor protein 1 (NLRP1), NOD-like receptor protein 3 (NLRP3), NOD-like receptor C4 (NLRC4), and absent in melanoma 2 (AIM2), among which NLRP3 inflammasome is the most studied. NLRP3 inflammasome is typically composed of NLRP3, ASC and pro-caspase-1. The activation of inflammasome involves both “classical” and “non-classical” pathways and the former pathway is better understood. The “classical” activation pathway of inflammasome is that the backbone protein is activated by endogenous/exogenous stimulation, leading to inflammasome assembly. After the formation of “classic” inflammasome, pro-caspase-1 could self-activate. Caspase-1 cleaves cytokine precursors into mature cytokines, which are secreted extracellularly. At present, the “non-classical” activation pathway of inflammasome has not formed a unified model for activation process. This article reviews the role of NLRP1, NLRP3, NLRC4, AIM2 inflammasome, Caspase-1, IL-1β, IL-18 and IL-33 in the fibrogenesis