2.79-μm high peak power LiNbO3 acousto-optic Q-switched Er,Cr:YSGG laser with thermal lensing effect compensation

A new type of lithium niobate (LiNbO3) acousto-optic Q-switched Er,Cr:YSGG laser with high peak power was designed and the thermal lensing effect compensation was studied. The values of thermal focal length in the gain medium were calculated theoretically and measured experimentally. The experimental results validate the designed plane-convex resonator validity, and the output performance of the 2.79 μm Er,Cr:YSGG laser was obviously improved. When the laser operated at free running region, the maximum values of pulse energy was 160 mJ at 60 Hz, compared with the plane-parallel resonator, the pulse energy was increased by 2 times in the plane-convex resonator. When the LiNbO3 Q-switched laser operated at 60 Hz, the maximum values of pulse energy was 8.5 mJ, and the minimum values of pulse duration was 60.8 ns, and the corresponding peak power approximately was 140 kW, respectively. Compared with the plane-parallel resonator, the pulse energy was increased by 1.6 times in the plane-convex resonator, the corresponding peak power was increased by 2.3 times

Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands

International audienceGlucose-stimulated insulin secretion (GSIS) from pancreatic beta cells is regulated by paracrine factors, the identity and mechanisms of action of which are incompletely understood. Activins are expressed in pancreatic islets and have been implicated in the regulation of GSIS. Activins A and B signal through a common set of intracellular components, but it is unclear whether they display similar or distinct functions in glucose homeostasis

Wearable Perovskite‐Based Shadow Recognition Sensor for Ambient and Nonobtrusive Human–Computer Interaction

Driven by the Internet of Everything, one of the main goals in human–computer interaction is to achieve intuitive, effortless, and easy‐to‐learn communication. Thus, senseless optoelectronic devices with high response performance under ambient environment have an extensive application space in improving the interfacing between users and computers. Herein, a concept of wearable perovskite‐based shadow recognition sensor is demonstrated for ambient and nonobtrusive human–computer interaction. The multidimensional ordered nucleation and growth of perovskite crystals are promoted by introducing the self‐driving effect of liquid crystal (LC) oligomers. The resulted LC‐doped perovskite film (LC‐PVK) with micrometer‐sized grains can output relatively high photocurrent under indoor ambient light (≈500 lux). The LC‐based device exhibits over a hundred times of on–off ratio and fast response of millisecond level even after storage for more than 1200 h. The device also shows an ultratrace Pb2+ leakage of 1.02 μg L−1 in water, and still retains more than 90% of the photocurrent intensity after thousands of bending strains. Accordingly, a novel human–computer interaction is achieved by identifying external action commands with the recognition of shadows, which can provide a “haptic” perception for robots

Lateral Heterostructured Vis–NIR Photodetectors with Multimodal Detection for Rapid and Precise Classification of Glioma

Precise diagnosis of the boundary and grade of tumors is especially important for surgical dissection. Recently, visible and near-infrared (Vis–NIR) absorption differences of tumors are demonstrated for a precise tumor diagnosis. Here, a template-assisted sequential printing strategy is investigated to construct lateral heterostructured Vis–NIR photodetectors, relying on the up-conversion nanoparticles (UCNPs)/perovskite arrays. Under the sequential printing process, the synergistic effect and co-confinement are demonstrated to induce the UCNPs to cover both sides of the perovskite microwire. The side-wrapped lateral heterogeneous UCNPs/perovskite structure exhibits more satisfactory responsiveness to Vis–NIR light than the common fully wrapped structure, due to sufficient visible-light-harvesting ability. The Vis–NIR photodetectors with R reaching 150 mA W–1 at 980 nm and 1084 A W–1 at 450 nm are employed for the rapid classification of glioma. The detection accuracy rate of 99.3% is achieved through a multimodal analysis covering the Vis–NIR light, which provides a reliable basis for glioma grade diagnosis. This work provides a concrete example for the application of photodetectors in tumor detection and surgical diagnosis

Lateral Heterostructured Vis–NIR Photodetectors with Multimodal Detection for Rapid and Precise Classification of Glioma

Precise diagnosis of the boundary and grade of tumors is especially important for surgical dissection. Recently, visible and near-infrared (Vis–NIR) absorption differences of tumors are demonstrated for a precise tumor diagnosis. Here, a template-assisted sequential printing strategy is investigated to construct lateral heterostructured Vis–NIR photodetectors, relying on the up-conversion nanoparticles (UCNPs)/perovskite arrays. Under the sequential printing process, the synergistic effect and co-confinement are demonstrated to induce the UCNPs to cover both sides of the perovskite microwire. The side-wrapped lateral heterogeneous UCNPs/perovskite structure exhibits more satisfactory responsiveness to Vis–NIR light than the common fully wrapped structure, due to sufficient visible-light-harvesting ability. The Vis–NIR photodetectors with R reaching 150 mA W–1 at 980 nm and 1084 A W–1 at 450 nm are employed for the rapid classification of glioma. The detection accuracy rate of 99.3% is achieved through a multimodal analysis covering the Vis–NIR light, which provides a reliable basis for glioma grade diagnosis. This work provides a concrete example for the application of photodetectors in tumor detection and surgical diagnosis

Lateral Heterostructured Vis–NIR Photodetectors with Multimodal Detection for Rapid and Precise Classification of Glioma

Precise diagnosis of the boundary and grade of tumors is especially important for surgical dissection. Recently, visible and near-infrared (Vis–NIR) absorption differences of tumors are demonstrated for a precise tumor diagnosis. Here, a template-assisted sequential printing strategy is investigated to construct lateral heterostructured Vis–NIR photodetectors, relying on the up-conversion nanoparticles (UCNPs)/perovskite arrays. Under the sequential printing process, the synergistic effect and co-confinement are demonstrated to induce the UCNPs to cover both sides of the perovskite microwire. The side-wrapped lateral heterogeneous UCNPs/perovskite structure exhibits more satisfactory responsiveness to Vis–NIR light than the common fully wrapped structure, due to sufficient visible-light-harvesting ability. The Vis–NIR photodetectors with R reaching 150 mA W–1 at 980 nm and 1084 A W–1 at 450 nm are employed for the rapid classification of glioma. The detection accuracy rate of 99.3% is achieved through a multimodal analysis covering the Vis–NIR light, which provides a reliable basis for glioma grade diagnosis. This work provides a concrete example for the application of photodetectors in tumor detection and surgical diagnosis

Change in caregiver health-related quality of life from before to early after surgery: SUSTAIN-IT study

Background: Information about health-related quality of life (HRQOL) among caregivers of older patients with heart failure who receive heart transplantation (HT) and mechanical circulatory support (MCS) is sparse. We describe differences and factors associated with change in HRQOL before and early post-surgery among caregivers of older heart failure patients who underwent 3 surgical therapies: HT with pretransplant MCS (HT MCS), HT without pretransplant MCS (HT non-MCS), and long-term MCS. Methods: Caregivers of older patients (60-80 years) from 13 US sites completed the EQ-5D-3 L visual analog scale (0 [worst]-100 [best] imaginable health state) and dimensions before and 3 and 6 months post-surgery. Analyses included linear regression, t tests, and nonparametric tests. Results: Among 227 caregivers (HT MCS=54, HT non-MCS=76, long-term MCS=97; median age 62.7 years, 30% male, 84% White, 83% spouse/partner), EQ-5D visual analog scale scores were high before (84.8±14.1) and at 3 (84.7±13.0) and 6 (83.9±14.7) months post-surgery, without significant differences among groups or changes over time. Patient pulmonary hypertension presurgery (β=-13.72 [95% CI, -21.07 to -6.36]; PP=0.035) were associated with the largest decrements in caregiver HRQOL; patient marital/partner status (β=6.21 [95% CI, 1.34-11.08]; P=0.013) and presurgery coronary disease (β=8.98 [95% CI, 4.07-13.89]; P Conclusions: Caregivers of older patients undergoing heart failure surgeries reported overall high HRQOL before and early post-surgery. Understanding factors associated with caregiver HRQOL may inform decision-making and support needs. Registration:NCT02568930