Exploiting individual creative inputs for team creativity: a role differentiation approach

Many creative tasks nowadays are undertaken by organizational teams. To produce high-quality outcomes in creative tasks (e.g., solutions, proposals, products) teams need to perform processes or activities, such as idea evaluation and selection, idea development, and idea implementation. The current literature on team creativity, however, has (implicitly) assumed that team members play the same role in performing creative tasks, ignoring the possibility that individuals specialize in their roles and differ in the creative processes or activities that they perform. In response, this dissertation offered a new perspective and developed the concept of role differentiation, to study the distribution of members’ engagement in different creative processes. Role differentiation is conceptualized as the extent to which team members specialize their engagement or participation during different taskwork (creativity) processes. Three chapters taken together explored 1) the effect of diversity of membership status and diversity of skills on the emergence of role differentiation; 2) the influence of role differentiation on team creativity and non-routine task performance; and 3) the contextual factors that affect the proposed relationships. Our findings provided support that teams specialize roles during creative processes (as a result of diversity), and such specialization benefited team performance especially when teams were under unfavorable situations (e.g., high pressure, lack of resources). In this regard, this dissertation has great practical implications in coordinating members’ engagement in creative tasks, and also offers important theoretical implications for team diversity and team creativity research

Numerical calculation and experimental research of pressure fluctuation in the pump under different operating conditions

Pressure fluctuation, which impacts on operating security, is the common phenomenon in the pump. In order to study pressure fluctuation phenomenon in the pump, TJ04-ZL-02 axial flow pump model is investigated under different operating conditions by experiment and unsteady calculation based on k-ω turbulence model. Numerical results show that the basic frequency amplitude of monitoring points in four sections under small operating condition are larger than that under design operating condition and large operating condition. And there are more random frequency components in each monitoring point, which are low frequency components. Experimental results show that compared with different operating conditions the basic frequency amplitude under design operation condition is not smallest. Under small operating condition the basic frequency amplitude is larger than that under large operating condition. Therefore, running under small operating condition will be easy to cause resonance. Based on this study, it’s recommended that avoiding small operating condition should contribute to improving operational stability

Membership change, idea generation, and group creativity:A motivated information processing perspective

Membership change has been found to stimulate collective idea generation but to not always benefit group creativity-the generation of final outcomes that are novel and useful. Based on motivated information processing theory, we propose that membership change challenges group members to generate more ideas, but that this only contributes to group creativity when members have high levels of prosocial motivation and are willing to process and integrate each other's ideas. In a laboratory study of 56 student groups, we found that incremental, but not radical, idea generation mediated the positive effect of membership change on group creativity, and only when group members were prosocially motivated. The present study points to different roles of incremental versus radical ideas and underscores the importance of accounting for prosocial motivation in groups for reaping the benefits of membership change in relation to group creativity

A Missense Mutation rs781536408 (c.2395G>A) of TYK2 Affects Splicing and Causes Skipping of Exon18 in vivo

TYK2 variants can impact disease onset or progression. In our previous study, we identified abnormal splicing that happened near rs781536408 in the TYK2 gene. The purpose of this research was to examine the effect of the mutation on alternative splicing in vivo and in vitro. Whole exome sequencing was performed to identify the mutations followed by bidirectional Sanger sequencing. Then the minigene analysis was carried out based on HeLa and HEK293T cell lines. The results showed that rs781536408 (c.2395G>A, p.G799R) was homozygous in the patient, but heterozygous in parents. PCR amplification confirmed the abnormal splicing in the somatic cells of the patients, but not in the parents. Sanger sequencing results showed that there was a skipping of exon18 near the mutation. For minigene analysis, there was no difference between the wild-type and the mutant type in the two minigene construction strategies, indicating that mutation c.2395G>A had no effect on splicing in vitro. Combining the results of in vivo, we speculated that the effect of the mutation on splicing was not absolute, but rather in degree

Critical parameters for the one-dimensional systems with long-range correlated disorder

We study the metal-insulator transition in a tight-binding one-dimensional (1D) model with long-range correlated disorder. In the case of diagonal disorder with site energy within $[-\frac{W}{2},\frac{W}{2}]$ and having a power-law spectral density $S(k)\propto k^{-\alpha}$, we investigate the competition between the disorder and correlation. Using the transfer-matrix method and finite-size scaling analysis, we find out that there is a finite range of extended eigenstates for $\alpha>2$, and the mobility edges are at $\pm E_{c}=\pm|2-W/2|$. Furthermore, we find the critical exponent $\nu$ of localization length ($\xi \sim |E-E_{c}|^{-\nu}$) to be $\nu=1+1.4e^{2-\alpha}$. Thus our results indicate that the disorder strength $W$ determines the mobility edges and the degree of correlation $\alpha$ determines the critical exponents.Comment: 6 pages, 6 figure

Intraoperative ultrasound-guided iodine-125 seed implantation for unresectable pancreatic carcinoma

<p>Abstract</p> <p>Background</p> <p>To assess the feasibility and efficacy of using ¹²⁵I seed implantation under intraoperative ultrasound guidance for unresectable pancreatic carcinoma.</p> <p>Methods</p> <p>Fourteen patients with pancreatic carcinoma that underwent laparotomy and considered unresectable were included in this study. Nine patients were pathologically diagnosed with Stage II disease, five patients with Stage III disease. Fourteen patients were treated with ¹²⁵I seed implantation guided by intraoperative ultrasound and received D₉₀of ¹²⁵I seeds ranging from 60 to 140 Gy with a median of 120 Gy. Five patients received an additional 35–50 Gy from external beam radiotherapy after seed implantation and six patients received 2–6 cycles of chemotherapy.</p> <p>Results</p> <p>87.5% (7/8) of patients received partial to complete pain relief. The response rate of tumor was 78.6%, One-, two-and three-year survival rates were 33.9% and 16.9%, 7.8%, with local control of disease achieved in 78.6% (11/14), and the median survival was 10 months (95% CI: 7.7–12.3).</p> <p>Conclusion</p> <p>There were no deaths related to ¹²⁵I seed implant. In this preliminary investigation, ¹²⁵I seed implant provided excellent palliation of pain relief, local control and prolong the survival of patients with stage II and III disease to some extent.</p

The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation

<p>Abstract</p> <p>Background</p> <p>This paper investigates the effects of a new radiosensitizer, doranidazole, and enhancing irradiation on colorectal cancer cells.</p> <p>Methods</p> <p>The radiosensitizing effect of doranidazole was determined using colony formation and propidium iodide (PI) assays to measure cell growth inhibition and the cell killing effect of human colorectal cancer cell lines exposed to high doses of γ-ray irradiation under hypoxic conditions <it>in vitro</it>. Fluorescence staining and cell migration assays were also used to assess the radiosensitizing effect.</p> <p>Results</p> <p>Cell proliferation evaluated by clonogenic survival curves was significantly inhibited by 5 mmol/L doranidazole, particularly at doses ranging from 10 to 30 Gy of irradiation. The radiosensitizing effect of doranidazole on colorectal cancer cells occurs in a time- and dose-dependent manner. Doranidazole also inhibited the mobility of cell invasion and migration.</p> <p>Conclusion</p> <p>Doranidazole can enhance the killing effect and the cell growth inhibition of colorectal cancer after high-dose irradiation in a time and dose-dependent manner.</p