8 research outputs found
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome
- Author
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA genome. The highly conserved frameshift stimulation element (FSE), required for balanced expression of viral proteins, is a particularly attractive SARS-CoV-2 RNA target. Here we present a 6.9 Å resolution cryo-EM structure of the FSE (88 nucleotides, ~28 kDa), validated through an RNA nanostructure tagging method. The tertiary structure presents a topologically complex fold in which the 5′ end is threaded through a ring formed inside a three-stem pseudoknot. Guided by this structure, we develop antisense oligonucleotides that impair FSE function in frameshifting assays and knock down SARS-CoV-2 virus replication in A549-ACE2 cells at 100 nM concentration
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
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- Barrington Seth
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- Song Guowei
- Song Haoyue
- Song Li
- Song Yiran
- Song Yong Rafael
- Soni Abhinav
- Sonnier Matt
- Spatharas Panagiotis
- Srinivasan Keerthana
- Standforth Kyle
- Starkel John
- Stewart Thomas
- Stocks Jon
- Strasser Dominik
- Street Morgan
- Stuhlweissenburg Fynn
- Stukenberg Daniel
- Sudarshan Bhuvana
- Suer Gun
- Sumner Kylie
- Sun Dongchang
- Sun Kai
- Sun Shiyu
- Sun Ting
- Suss Beatrix
- Swart Pim
- Sweet Bailey
- Tairan Li
- Takeyasu Reanna
- Tamayo Diana
- Tan Huishuang
- Tan Li Yang
- Tang Cassie
- Tang Christian
- Tang Erting
- Tang Jiaqi
- Tang Weiyi
- Tang Yu-Cheng
- Tang Yu-Hsin
- Tao Yibing
- Tapia Jennifer
- Tariq Ali
- Taskar Poorva
- Taylor Max
- Telesz Lauren
- ten Dam Marjolijn
- Tharp Darron
- Thokachichu Pranav
- Thomas Sophie
- Thormar Eirikur Andri
- Throsberg Christian
- Tian Hong
- Tian Qinghe
- Tian Ruonan
- Tianyi Chang
- Ting Weiyu
- Tirad Alice
- Toanen Marion
- Tobin David
- Toghani Dorsa
- Torell Agnes
- Toro Bibiana
- Torres Ares
- Totten Stephanie
- Trevizo Cynthia Lizeth Gonzalez
- Trivellin Cecilia
- Trujillo-Rodriguez Lidimarie
- Tsai Leona
- Tsai You-Yang
- Tsang Helen
- Tsitsilonis Ourania E.
- Tsui Jennifer
- Tunaj Brigit
- Turner Matthew
- Turton Kristi
- Tutuianu Anna
- Tuzov Vladislav
- Twisk Simone
- Ucan Kutay
- Uday Adwaith B.
- Ueding Elisa
- Unal Tunc
- Urban Julia
- Uslu Attila
- Vaidya Anjali
- Vaitkus Dovydas
- Vanini Nadine Vaz
- Varaljay Vanessa
- Vardi Omri
- Velasco Maria Antonia Luna
- Velikov Lukas
- Vella Toni
- Venclovas Tomas
- Venkatraghavan Sankalpa
- Verhagen Mick
- Verma Yashna
- Vignoni Alejandro
- Vincent Annette
- Vincent Sara
- Viswanathan Ashwin
- Vitkute Kornelija
- von Schoenberg Sophie
- Voort Gemma van der
- Vornholt Tobias
- Vries Philip Gorter de
- Waard Jazzy de
- Wadhams George
- Wagner Camille
- Wai Leung Chung
- Wan Chan Tsey
- Wan Leon
- Wan Mitchell
- Wang Cheng-Chieh
- Wang Chenxi
- Wang Choi Seong
- Wang Hao
- Wang Huichao
- Wang Kai
- Wang Kelsey
- Wang Kelsey
- Wang Ken
- Wang Li
- Wang Pengying
- Wang Ping
- Wang Qiupeng
- Wang Raven
- Wang Sibo
- Wang Sihan
- Wang Tian
- Wang Wei
- Wang Xiangxuan
- Wang Xin
- Wang Xinyue
- Wang Xuan
- Wang Xueyao
- Wang Yaling
- Wang Yi
- Wang Yifan
- Wang Yuefei
- Wang Yunyi
- Wang Yuyang
- Wang Yuyao
- Wang Zihao
- Wang Ziru
- Wang Ziyu
- Wanji Li
- Warzecha Heribert
- Watson Emily
- Wawrzyniak Dominika
- Weber Elisa
- Wei Zemeng
- Weile Carl
- Wenhao Xu
- Went Sam
- Whalen Kathleen
- Whiteside Jonny
- Whittle Michaella
- Wickiser Ken
- Windo Joe
- Wintermute Edwin
- Withanage Shamal
- Wolfbeisz Chiara
- Wong Angel
- Wong Hei Man
- Wong Joanne
- Woodward Noble
- Workman C. T.
- Wu Chenhai
- Wu Justin
- Wu Kangjie
- Wu Mengxuan
- Wu Michelle
- Wu Yaxuan
- Wu Yi
- Wu Yuxuan
- Wu Zishi
- Xi Yukun
- Xia Ruoyu
- Xiang Meredith
- Xiang Yuening
- Xiao Ziyang
- Xiaojin Li
- Xiaowen Mao
- Xilei Peng
- Xin Li
- Xin Tian
- Xing Jinming
- Xinguang Chen
- Xinlei Fang
- Xinyu Liu
- Xinyu Liu
- Xinyu Teng
- Xinyue Ma
- Xiong Xin
- Xiong Zhenyu
- Xirui Chen
- Xiu Yao
- Xiujing Hong
- Xu Guiyang
- Xu Hanning
- Xu Hao
- Xu Huandi
- Xu Sheng
- Xu Shirly
- Xu Xia
- Xu Xin
- Xu Yinsong
- Xuan Chen Zi
- Xue Fang
- Xue Han
- Xun Shu
- Yadav Ravineet
- Yadav Yash
- Yadi Liu
- Yan Calvin
- Yan Cathy
- Yan Han
- Yan Hongfa
- Yan Qingyan
- Yan Tsui Shing
- Yan Yeung Wing
- Yan Yining
- Yang Chao
- Yang Chenghao
- Yang Chuyi
- Yang Fan
- Yang Fuqiang
- Yang Hanyeol
- Yang Jake
- Yang Jianzhe
- Yang Jindian
- Yang Jinshu
- Yang Jun
- Yang Leyi
- Yang Ruofan
- Yang Shaobo
- Yang Shuting
- Yang Xilin
- Yang Yuchen
- Yang Zhuoyi
- Yang Zisang
- Yang Zon En
- Yao Andrew
- Yarbrough Hayden
- Yaxi Zhang
- Ye Yusheng
- Yee Chong Yuk
- Yeh Chan-yu
- Yehouessi Tamara
- Yeliseyeva Hanna
- Yesley Phillip
- Yeung Wong Tsz
- Yifan Li
- Yihang Qiu
- Yiming Quan
- Yin Jiacheng
- Yin Lee Ka
- Yin Xianqi
- Yong Nur Liyana Binte Ayub Ow
- Yong Zhangxiang
- Yongjie Lin
- Yoo Hojun
- Yoon Soohyun
- You Jaewon
- Young Cam
- Yu Haimeng
- Yu Jiacheng
- Yu Kai-Chiang
- Yu Liuhong
- Yu Tam Chi
- Yu Wenfei
- Yu Yuen Wai
- Yuan Hetian
- Yuan Long
- Yuan Xing
- Yuan Zhe
- Yuanxu Jiang
- Yucheng Chen
- Yue Qing
- Yueyi Li
- Yuhan Cheng
- Yujie Peng
- Yun Yejie
- Yung Jay
- Yutong Pan
- Zadeh Daniel
- Zamora Alejandro Robles
- Zanoni Paul
- Zanotti Violetta
- Zeng Chenxu
- Zeng Yuanhong
- Zepeng Xu
- Zerva Anastasia
- Zhan Yang
- Zhang Alice
- Zhang Bonan
- Zhang Jianxiang
- Zhang Jige
- Zhang Jinhan
- Zhang Kaida
- Zhang Kecheng
- Zhang Qian
- Zhang Shuyan
- Zhang Tianyi
- Zhang Wanli
- Zhang Xianyin
- Zhang Xinyu
- Zhang Yihao
- Zhang Yuanzhen
- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Recommended from our members
Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge
- Author
- Acharya Gagan
- Agarwal Manu
- Alam Mahbubul
- Alberts Esther
- Albiol Alberto
- Albiol Antonio
- Albiol Francisco J
- Alex Varghese
- Allinson Nigel
- Amorim Pedro HA
- Amrutkar Abhijit
- Anand Ganesh
- Andermatt Simon
- Arbel Tal
- Arbelaez Pablo
- Avery Aaron
- Azmat Muneeza
- Bai W
- Baid Ujjwal
- Bakas Spyridon
- Banerjee Subhashis
- Barth Bill
- Batchelder Thomas
- Batmanghelich Kayhan
- Battistella Enzo
- Bauer Stefan
- Beers Andrew
- Belyaev Mikhail
- Bendszus Martin
- Benson Eze
- Berger Christoph
- Bernal Jose
- Bharath Halandur Nagaraja
- Bilello Michel
- Biros George
- Bisdas Sotirios
- Brown James
- Cabezas Mariano
- Cao Shilei
- Cardoso Jorge M
- Carver Eric N
- Casamitjana Adrià
- Castillo Laura Silvana
- Cattin Philippe
- Catà Marcel
- Cerigues Albert
- Chagas Vinicius S
- Chandra Siddhartha
- Chang Ken
- Chang Shiyu
- Chang Yi-Ju
- Chazalon Joseph
- Chen Jefferson W
- Chen Shengcong
- Chen Wei
- Chen Zhaolin
- Cheng Kun
- Choudhury Ahana Roy
- Chylla Roger
- Clérigues Albert
- Colen Rivka
- Colleman Steven
- Colmeiro Ramiro German Rodriguez
- Combalia Marc
- Costa Anthony
- Crimi Alessandro
- Cui Xiaomeng
- Dai Lutao
- Dai Zhenzhen
- Davatzikos Christos
- Daza Laura Alexandra
- Deutsch Eric
- Ding Changxing
- Dong Chao
- Dong Shidu
- Dudzik Wojciech
- Eaton-Rosen Zach
- Egan Gary
- Escudero Guilherme
- Estienne Théo
- Everson Richard
- Fabrizio Jonathan
- Fan Yong
- Fang Longwei
- Farahani Keyvan
- Fathallah-Shaykh Hassan
- Feng Xue
- Ferrante Enzo
- Fidon Lucas
- Fischer Martin
- French Andrew P
- Freymann John
- Fridman Naomi
- Fu Huan
- Fuentes David
- Gao Yaozong
- Gates Evan
- Gering David
- Gerstner Elizabeth
- Gholami Amir
- Gierke Willi
- Glocker Ben
- Gong Mingming
- González-Villá Sandra
- Grosges T
- Guan Yuanfang
- Guo Sheng
- Gupta Sudeep
- Ha Sung Min
- Han Il Song
- Han Woo-Sup
- Harmuth Konstantin
- He Huiguang
- Hernández-Sabaté Aura
- Herrmann Evelyn
- Himthani Naveen
- Hsu Cheyu
- Hsu Winston
- Hu Xiaobin
- Hu Xiaojun
- Hu Yan
- Hu Yifan
- Hua Rui
- Huang Teng-Yi
- Huang Weilin
- Huffel Sabine Van
- Huo Quan
- Iftekharuddin Khan M
- Isensee Fabian
- Islam Mobarakol
- Jackson Aaron S
- Jakab Andras
- Jambawalikar Sachin R
- Jesson Andrew
- Jian Weijian
- Jin Peter
- Jose V Jeya Maria
- Jungo Alain
- Kainz B
- Kalpathy-Cramer Jayashree
- Kamnitsas Konstantinos
- Kao Po-Yu
- Karnawat Ayush
- Kellermeier Thomas
- Kermi Adel
- Keutzer Kurt
- Khadir Mohamed Tarek
- Khened Mahendra
- Kickingereder Philipp
- Kim Geena
- King Nik
- Kirby Justin
- Kirschke Jan
- Knapp Haley
- Knecht Urspeter
- Kohli Lisa
- Kong Deren
- Kong Xiangmao
- Koppers Simon
- Kori Avinash
- Kotrotsou Aikaterini
- Krishnamurthi Ganapathy
- Krivov Egor
- Kumar Piyush
- Kushibar Kaisar
- Kwon Dongjin
- Lachinov Dmitrii
- Lambrou Tryphon
- Lamontagne Pamela
- Lee Chengen
- Lee Joon
- Lee M
- Lee Yuehchou
- Leemput Koen van
- Lefkovits Laszlo
- Lefkovits Szidonia
- Levitt James
- Li Heng
- Li Hongwei
- Li Hongyang
- Li Tengfei
- Li Wenqi
- Li Wenqi
- Li Xiaochuan
- Li XiaoGang
- Li Xiaoyu
- Li Yuexiang
- Li Zeju
- Li Zhenye
- Lin Fengming
- Lin Zheng-Shen
- Lio Pietro
- Lipkova Jana
- Liu Boqiang
- Liu Chang
- Liu Ju
- Liu Luyan
- Liu Mingyuan
- Liu Xiang
- Llado Xavier
- Lopez Marc Moreno
- Lorenzo Pablo Ribalta
- Lu Zhentai
- Luo Lin
- Luo Zhigang
- Ma Jun
- Ma Kai
- Mackie Thomas
- Madabushi Anant
- Mahajan Abhishek
- Mahmoudi Issam
- Maier-Hein Klaus H
- Maji Pradipta
- Mammen CP
- Mang Andreas
- Manjunath BS
- Marcinkiewicz Michal
- Marcus Daniel
- McDonagh S
- McKenna Stephen
- McKinley Richard
- Mehl Miriam
- Mehta Raghav
- Mehta Sachin
- Meier Raphael
- Meinel Christoph
- Menze Bjoern
- Merhof Dorit
- Meyer Craig
- Milchenko Mikhail
- Miller Robert
- Mitra Sushmita
- Moiyadi Aliasgar
- Molina-Garcia David
- Monteiro Miguel AB
- Mrukwa Grzegorz
- Myronenko Andriy
- Nalepa Jakub
- Nazeri Arash
- Ngo Thuyen
- Nie Dong
- Ning Holly
- Niu Chen
- Nuechterlein Nicholas K
- Oermann Eric
- Oliveira Arlindo
- Oliveira Diego DC
- Oliver Arnau
- Osman Alexander FI
- Ou Yu-Nian
- Ourselin Sebastien
- Paragios Nikos
- Park Moo Sung
- Paschke Brad
- Pauloski J Gregory
- Pawar Kamlesh
- Pawlowski Nick
- Pei Linmin
- Peng Suting
- Pereira Silvio M
- Perez-Beteta Julian
- Perez-Garcia Victor M
- Pezold Simon
- Pham Bao
- Phophalia Ashish
- Piella Gemma
- Pillai GN
- Piraud Marie
- Pisov Maxim
- Popli Anmol
- Pound Michael P
- Pourreza Reza
- Pranjal B
- Prasanna Prateek
- Prastawa Marcel
- Pridmore Tony P
- Prkovska Vesna
- Puch Santi
- Puybareau Élodie
- Qian Buyue
- Qiao Xu
- Rajchl Martin
- Rane Swapnil
- Rebsamen Michael
- Rempfler Markus
- Ren Hongliang
- Ren Xuhua
- Revanuru Karthik
- Reyes Mauricio
- Rezaei Mina
- Rippel Oliver
- Rivera Luis Carlos
- Robert Charlotte
- Rosen Bruce
- Rozycki Martin
- Rueckert Daniel
- Safwan Mohammed
- Salem Mostafa
- Salvi Joaquim
- Sanchez Irina
- Santos Heitor M
- Sartor Emmett
- Schellingerhout Dawid
- Scheufele Klaudius
- Scott Matthew R
- Scussel Artur A
- Sedlar Sara
- Serrano-Rubio Juan Pablo
- Shah N Jon
- Shah Nameetha
- Shaikh Mazhar
- Shankar B Uma
- Shboul Zeina
- Shen Dinggang
- Shen Haipeng
- Shen Haocheng
- Shen Linlin
- Shenoy Varun
- Shi Feng
- Shin Hyung Eun
- Shinohara Russell Takeshi
- Shu Hai
- Sima Diana
- Sinclair M
- Smedby Orjan
- Snyder James M
- Soltaninejad Mohammadreza
- Song Guidong
- Soni Mehul
- Stawiaski Jean
- Subramanian Shashank
- Sun Guoxia
- Sun Jiawei
- Sun Kay
- Sun Li
- Sun Roger
- Sun Shuang
- Sun Yu
- Suter Yannick R
- Szilagyi Laszlo
- Sánchez Irina
- Talbar Sanjay
- Tao Dacheng
- Tao Dacheng
- Teng Zhongzhao
- Thakur Meenakshi H
- Thakur Siddhesh
- Tharakan Sameer
- Tiwari Pallavi
- Tochon Guillaume
- Tran Tuan
- Tsai Yuhsiang M
- Tseng Kuan-Lun
- Tuan Tran Anh
- Turlapov Vadim
- Tustison Nicholas
- Vakalopoulou Maria
- Valverde Sergi
- Vanguri Rami
- Vasiliev Evgeny
- Ventura Jonathan
- Vera Luis
- Vercauteren Tom
- Verrastro CA
- Vidyaratne Lasitha
- Vilaplana Veronica
- Vivek HV
- Vivekanandan Ajeet
- Wang Chiatse J
- Wang Chunliang
- Wang Duo
- Wang Guotai
- Wang Guotai
- Wang Qian
- Wang Ruixuan
- Wang Weichung
- Wang Yuanyuan
- Weber Marc-Andre
- Wen Ning
- Wen Xin
- Weninger Leon
- Wick Wolfgang
- Wiest Roland
- Wiestler Benedikt
- Wu Qiang
- Wu Shaocheng
- Wu Yihong
- Xia Yong
- Xu Peiyuan
- Xu Xiaowen
- Xu Yanwu
- Yang Guang
- Yang Hao-Yu
- Yang Haojin
- Yang Junlin
- Yang Tsai-Ling
- Yang Xiaoping
- Yao Hongdou
- Ye Xujiong
- Yin Changchang
- Young-Moxon Brett
- Yu Jinhua
- Yue Xiangyu
- Zhang Angela
- Zhang Jianguo
- Zhang Kun
- Zhang Lei
- Zhang Lichi
- Zhang Songtao
- Zhang Tianhao
- Zhang Xiang
- Zhang Xiaoyue
- Zhang Xuejie
- Zhang Yazhuo
- Zhao Liang
- Zhao Sicheng
- Zhao Xiaomei
- Zhao Yu
- Zheng Yefeng
- Zhong Liming
- Zhou Chenhong
- Zhou Fan
- Zhou Xiaobing
- Zhu Hongtu
- Zhu Jin
- Zhuge Ying
- Zong Weiwei
- Publication venue
- Publication date
- 13/04/2019
- Field of study
Gliomas are the most common primary brain malignancies, with different
degrees of aggressiveness, variable prognosis and various heterogeneous
histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic
core, active and non-enhancing core. This intrinsic heterogeneity is also
portrayed in their radio-phenotype, as their sub-regions are depicted by
varying intensity profiles disseminated across multi-parametric magnetic
resonance imaging (mpMRI) scans, reflecting varying biological properties.
Their heterogeneous shape, extent, and location are some of the factors that
make these tumors difficult to resect, and in some cases inoperable. The amount
of resected tumor is a factor also considered in longitudinal scans, when
evaluating the apparent tumor for potential diagnosis of progression.
Furthermore, there is mounting evidence that accurate segmentation of the
various tumor sub-regions can offer the basis for quantitative image analysis
towards prediction of patient overall survival. This study assesses the
state-of-the-art machine learning (ML) methods used for brain tumor image
analysis in mpMRI scans, during the last seven instances of the International
Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we
focus on i) evaluating segmentations of the various glioma sub-regions in
pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue
of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO
criteria, and iii) predicting the overall survival from pre-operative mpMRI
scans of patients that underwent gross total resection. Finally, we investigate
the challenge of identifying the best ML algorithms for each of these tasks,
considering that apart from being diverse on each instance of the challenge,
the multi-institutional mpMRI BraTS dataset has also been a continuously
evolving/growing dataset
Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge
- Author
- Acharya Gagan
- Agarwal Manu
- Alam Mahbubul
- Alberts Esther
- Albiol Alberto
- Albiol Antonio
- Albiol Francisco J
- Alex Varghese
- Allinson Nigel
- Amorim Pedro HA
- Amrutkar Abhijit
- Anand Ganesh
- Andermatt Simon
- Arbel Tal
- Arbelaez Pablo
- Avery Aaron
- Azmat Muneeza
- Bai W
- Baid Ujjwal
- Bakas Spyridon
- Banerjee Subhashis
- Barth Bill
- Batchelder Thomas
- Batmanghelich Kayhan
- Battistella Enzo
- Bauer Stefan
- Beers Andrew
- Belyaev Mikhail
- Bendszus Martin
- Benson Eze
- Berger Christoph
- Bernal Jose
- Bharath Halandur Nagaraja
- Bilello Michel
- Biros George
- Bisdas Sotirios
- Brown James
- Cabezas Mariano
- Cao Shilei
- Cardoso Jorge M
- Carver Eric N
- Casamitjana Adrià
- Castillo Laura Silvana
- Cattin Philippe
- Catà Marcel
- Cerigues Albert
- Chagas Vinicius S
- Chandra Siddhartha
- Chang Ken
- Chang Shiyu
- Chang Yi-Ju
- Chazalon Joseph
- Chen Jefferson W
- Chen Shengcong
- Chen Wei
- Chen Zhaolin
- Cheng Kun
- Choudhury Ahana Roy
- Chylla Roger
- Clérigues Albert
- Colen Rivka
- Colleman Steven
- Colmeiro Ramiro German Rodriguez
- Combalia Marc
- Costa Anthony
- Crimi Alessandro
- Cui Xiaomeng
- Dai Lutao
- Dai Zhenzhen
- Davatzikos Christos
- Daza Laura Alexandra
- Deutsch Eric
- Ding Changxing
- Dong Chao
- Dong Shidu
- Dudzik Wojciech
- Eaton-Rosen Zach
- Egan Gary
- Escudero Guilherme
- Estienne Théo
- Everson Richard
- Fabrizio Jonathan
- Fan Yong
- Fang Longwei
- Farahani Keyvan
- Fathallah-Shaykh Hassan
- Feng Xue
- Ferrante Enzo
- Fidon Lucas
- Fischer Martin
- French Andrew P
- Freymann John
- Fridman Naomi
- Fu Huan
- Fuentes David
- Gao Yaozong
- Gates Evan
- Gering David
- Gerstner Elizabeth
- Gholami Amir
- Gierke Willi
- Glocker Ben
- Gong Mingming
- González-Villá Sandra
- Grosges T
- Guan Yuanfang
- Guo Sheng
- Gupta Sudeep
- Ha Sung Min
- Han Il Song
- Han Woo-Sup
- Harmuth Konstantin
- He Huiguang
- Hernández-Sabaté Aura
- Herrmann Evelyn
- Himthani Naveen
- Hsu Cheyu
- Hsu Winston
- Hu Xiaobin
- Hu Xiaojun
- Hu Yan
- Hu Yifan
- Hua Rui
- Huang Teng-Yi
- Huang Weilin
- Huffel Sabine Van
- Huo Quan
- Iftekharuddin Khan M
- Isensee Fabian
- Islam Mobarakol
- Jackson Aaron S
- Jakab Andras
- Jambawalikar Sachin R
- Jesson Andrew
- Jian Weijian
- Jin Peter
- Jose V Jeya Maria
- Jungo Alain
- Kainz B
- Kalpathy-Cramer Jayashree
- Kamnitsas Konstantinos
- Kao Po-Yu
- Karnawat Ayush
- Kellermeier Thomas
- Kermi Adel
- Keutzer Kurt
- Khadir Mohamed Tarek
- Khened Mahendra
- Kickingereder Philipp
- Kim Geena
- King Nik
- Kirby Justin
- Kirschke Jan
- Knapp Haley
- Knecht Urspeter
- Kohli Lisa
- Kong Deren
- Kong Xiangmao
- Koppers Simon
- Kori Avinash
- Kotrotsou Aikaterini
- Krishnamurthi Ganapathy
- Krivov Egor
- Kumar Piyush
- Kushibar Kaisar
- Kwon Dongjin
- Lachinov Dmitrii
- Lambrou Tryphon
- Lamontagne Pamela
- Lee Chengen
- Lee Joon
- Lee M
- Lee Yuehchou
- Leemput Koen van
- Lefkovits Laszlo
- Lefkovits Szidonia
- Levitt James
- Li Heng
- Li Hongwei
- Li Hongyang
- Li Tengfei
- Li Wenqi
- Li Wenqi
- Li Xiaochuan
- Li XiaoGang
- Li Xiaoyu
- Li Yuexiang
- Li Zeju
- Li Zhenye
- Lin Fengming
- Lin Zheng-Shen
- Lio Pietro
- Lipkova Jana
- Liu Boqiang
- Liu Chang
- Liu Ju
- Liu Luyan
- Liu Mingyuan
- Liu Xiang
- Llado Xavier
- Lopez Marc Moreno
- Lorenzo Pablo Ribalta
- Lu Zhentai
- Luo Lin
- Luo Zhigang
- Ma Jun
- Ma Kai
- Mackie Thomas
- Madabushi Anant
- Mahajan Abhishek
- Mahmoudi Issam
- Maier-Hein Klaus H
- Maji Pradipta
- Mammen CP
- Mang Andreas
- Manjunath BS
- Marcinkiewicz Michal
- Marcus Daniel
- McDonagh S
- McKenna Stephen
- McKinley Richard
- Mehl Miriam
- Mehta Raghav
- Mehta Sachin
- Meier Raphael
- Meinel Christoph
- Menze Bjoern
- Merhof Dorit
- Meyer Craig
- Milchenko Mikhail
- Miller Robert
- Mitra Sushmita
- Moiyadi Aliasgar
- Molina-Garcia David
- Monteiro Miguel AB
- Mrukwa Grzegorz
- Myronenko Andriy
- Nalepa Jakub
- Nazeri Arash
- Ngo Thuyen
- Nie Dong
- Ning Holly
- Niu Chen
- Nuechterlein Nicholas K
- Oermann Eric
- Oliveira Arlindo
- Oliveira Diego DC
- Oliver Arnau
- Osman Alexander FI
- Ou Yu-Nian
- Ourselin Sebastien
- Paragios Nikos
- Park Moo Sung
- Paschke Brad
- Pauloski J Gregory
- Pawar Kamlesh
- Pawlowski Nick
- Pei Linmin
- Peng Suting
- Pereira Silvio M
- Perez-Beteta Julian
- Perez-Garcia Victor M
- Pezold Simon
- Pham Bao
- Phophalia Ashish
- Piella Gemma
- Pillai GN
- Piraud Marie
- Pisov Maxim
- Popli Anmol
- Pound Michael P
- Pourreza Reza
- Pranjal B
- Prasanna Prateek
- Prastawa Marcel
- Pridmore Tony P
- Prkovska Vesna
- Puch Santi
- Puybareau Élodie
- Qian Buyue
- Qiao Xu
- Rajchl Martin
- Rane Swapnil
- Rebsamen Michael
- Rempfler Markus
- Ren Hongliang
- Ren Xuhua
- Revanuru Karthik
- Reyes Mauricio
- Rezaei Mina
- Rippel Oliver
- Rivera Luis Carlos
- Robert Charlotte
- Rosen Bruce
- Rozycki Martin
- Rueckert Daniel
- Safwan Mohammed
- Salem Mostafa
- Salvi Joaquim
- Sanchez Irina
- Santos Heitor M
- Sartor Emmett
- Schellingerhout Dawid
- Scheufele Klaudius
- Scott Matthew R
- Scussel Artur A
- Sedlar Sara
- Serrano-Rubio Juan Pablo
- Shah N Jon
- Shah Nameetha
- Shaikh Mazhar
- Shankar B Uma
- Shboul Zeina
- Shen Dinggang
- Shen Haipeng
- Shen Haocheng
- Shen Linlin
- Shenoy Varun
- Shi Feng
- Shin Hyung Eun
- Shinohara Russell Takeshi
- Shu Hai
- Sima Diana
- Sinclair M
- Smedby Orjan
- Snyder James M
- Soltaninejad Mohammadreza
- Song Guidong
- Soni Mehul
- Stawiaski Jean
- Subramanian Shashank
- Sun Guoxia
- Sun Jiawei
- Sun Kay
- Sun Li
- Sun Roger
- Sun Shuang
- Sun Yu
- Suter Yannick R
- Szilagyi Laszlo
- Sánchez Irina
- Talbar Sanjay
- Tao Dacheng
- Tao Dacheng
- Teng Zhongzhao
- Thakur Meenakshi H
- Thakur Siddhesh
- Tharakan Sameer
- Tiwari Pallavi
- Tochon Guillaume
- Tran Tuan
- Tsai Yuhsiang M
- Tseng Kuan-Lun
- Tuan Tran Anh
- Turlapov Vadim
- Tustison Nicholas
- Vakalopoulou Maria
- Valverde Sergi
- Vanguri Rami
- Vasiliev Evgeny
- Ventura Jonathan
- Vera Luis
- Vercauteren Tom
- Verrastro CA
- Vidyaratne Lasitha
- Vilaplana Veronica
- Vivek HV
- Vivekanandan Ajeet
- Wang Chiatse J
- Wang Chunliang
- Wang Duo
- Wang Guotai
- Wang Guotai
- Wang Qian
- Wang Ruixuan
- Wang Weichung
- Wang Yuanyuan
- Weber Marc-Andre
- Wen Ning
- Wen Xin
- Weninger Leon
- Wick Wolfgang
- Wiest Roland
- Wiestler Benedikt
- Wu Qiang
- Wu Shaocheng
- Wu Yihong
- Xia Yong
- Xu Peiyuan
- Xu Xiaowen
- Xu Yanwu
- Yang Guang
- Yang Hao-Yu
- Yang Haojin
- Yang Junlin
- Yang Tsai-Ling
- Yang Xiaoping
- Yao Hongdou
- Ye Xujiong
- Yin Changchang
- Young-Moxon Brett
- Yu Jinhua
- Yue Xiangyu
- Zhang Angela
- Zhang Jianguo
- Zhang Kun
- Zhang Lei
- Zhang Lichi
- Zhang Songtao
- Zhang Tianhao
- Zhang Xiang
- Zhang Xiaoyue
- Zhang Xuejie
- Zhang Yazhuo
- Zhao Liang
- Zhao Sicheng
- Zhao Xiaomei
- Zhao Yu
- Zheng Yefeng
- Zhong Liming
- Zhou Chenhong
- Zhou Fan
- Zhou Xiaobing
- Zhu Hongtu
- Zhu Jin
- Zhuge Ying
- Zong Weiwei
- Publication venue
- Publication date
- 05/11/2018
- Field of study
Gliomas are the most common primary brain malignancies, with different
degrees of aggressiveness, variable prognosis and various heterogeneous
histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic
core, active and non-enhancing core. This intrinsic heterogeneity is also
portrayed in their radio-phenotype, as their sub-regions are depicted by
varying intensity profiles disseminated across multi-parametric magnetic
resonance imaging (mpMRI) scans, reflecting varying biological properties.
Their heterogeneous shape, extent, and location are some of the factors that
make these tumors difficult to resect, and in some cases inoperable. The amount
of resected tumor is a factor also considered in longitudinal scans, when
evaluating the apparent tumor for potential diagnosis of progression.
Furthermore, there is mounting evidence that accurate segmentation of the
various tumor sub-regions can offer the basis for quantitative image analysis
towards prediction of patient overall survival. This study assesses the
state-of-the-art machine learning (ML) methods used for brain tumor image
analysis in mpMRI scans, during the last seven instances of the International
Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we
focus on i) evaluating segmentations of the various glioma sub-regions in
pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue
of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO
criteria, and iii) predicting the overall survival from pre-operative mpMRI
scans of patients that underwent gross total resection. Finally, we investigate
the challenge of identifying the best ML algorithms for each of these tasks,
considering that apart from being diverse on each instance of the challenge,
the multi-institutional mpMRI BraTS dataset has also been a continuously
evolving/growing dataset
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
- Author
- Abdelmohsen Kotb
- Abe Akihisa
- Abedin Md Joynal
- Abeliovich Hagai
- Adachi Hiroaki
- Adams Christopher M.
- Adams Peter D.
- Adeli Khosrow
- Adhihetty Peter J.
- Adler Sharon G.
- Agam Galila
- Agarwal Rajesh
- Aghi Manish K.
- Agnello Maria
- Agostinis Patrizia
- Aguilar Patricia V.
- Aguirre-Ghiso Julio
- Airoldi Edoardo M.
- Ait-Si-Ali Slimane
- Akematsu Takahiko
- Akporiaye Emmanuel T.
- Al-Rubeai Mohamed
- Albaiceta Guillermo M.
- Albanese Chris
- Albani Diego
- Albert Matthew L.
- Aldudo Jesus
- Algül Hana
- Alirezaei Mehrdad
- Alloza Iraide
- Almasan Alexandru
- Almonte-Beceril Maylin
- Alnemri Emad S.
- Alonso Covadonga
- Altan-Bonnet Nihal
- Altieri Dario C.
- Alvarez Silvia
- Alvarez-Erviti Lydia
- Alves Sandro
- Amadoro Giuseppina
- Amano Atsuo
- Amantini Consuelo
- Ambrosio Santiago
- Amelio Ivano
- Amer Amal O.
- Amessou Mohamed
- Amon Angelika
- An Zhenyi
- Anania Frank A.
- Andersen Stig U.
- Andley Usha P.
- Andreadi Catherine K.
- Andrieu-Abadie Nathalie
- Anel Alberto
- Ann David K.
- Anoopkumar-Dukie Shailendra
- Antonioli Manuela
- Aoki Hiroshi
- Apostolova Nadezda
- Aquila Saveria
- Aquilano Katia
- Araki Koichi
- Arama Eli
- Aranda Agustin
- Araya Jun
- Arcaro Alexandre
- Arias Esperanza
- Arimoto Hirokazu
- Ariosa Aileen R.
- Armstrong Jane L.
- Arnould Thierry
- Arozena Abraham Acevedo
- Arsov Ivica
- Asanuma Katsuhiko
- Askanas Valerie
- Asselin Eric
- Atarashi Ryuichiro
- Atherton Sally S.
- Atkin Julie D.
- Attardi Laura D.
- Auberger Patrick
- Auburger Georg
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avantaggiati Maria Laura
- Avrahami Limor
- Awale Suresh
- Azad Neelam
- Bachetti Tiziana
- Backer Jonathan M.
- Bae Dong-Hun
- Bae Jae-Sung
- Bae Ok-Nam
- Bae Soo Han
- Baehrecke Eric H.
- Baek Seung-Hoon
- Baghdiguian Stephen
- Bagniewska-Zadworna Agnieszka
- Bai Hua
- Bai Jie
- Bai Xue-Yuan
- Bailly Yannick
- Balaji Kithiganahalli Narayanaswamy
- Balduini Walter
- Ballabio Andrea
- Balzan Rena
- Banerjee Rajkumar
- Bao Haijun
- Barbato Daniele Lettieri
- Barbeau Benoit
- Barrachina Maria D.
- Barreiro Esther
- Bartel Bonnie
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- Bassham Diane C.
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- Beaulieu Jean-François
- Beck George R.
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- Bejarano Eloy
- Belaid Amine
- Belleudi Francesca
- Berchem Guy
- Bergamaschi Daniele
- Bergami Matteo
- Berkhout Ben
- Berliocchi Laura
- Bernard Amélie
- Bernard Monique
- Bernassola Francesca
- Bertolotti Anne
- Bess Amanda S.
- Besteiro Sébastien
- Bettuzzi Saverio
- Bhalla Savita
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- Billes Viktor
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- Bitoun Marc
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- Cavallini Gabriella
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- Chen Peiwen
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- Chen Shang-Der
- Chen Si
- Chen Steve S. -L.
- Chen Wei
- Chen Wei-Jung
- Chen Wen Qiang
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- Chen Yau-Hung
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- Chou Tsui-Fen
- Chouaib Salem
- Choubey Divaker
- Choubey Vinay
- Chow Kuan-Chih
- Chowdhury Kamal
- Chu Charleen T.
- Chuang Tsung-Hsien
- Chun Taehoon
- Chung Hyewon
- Chung Taijoon
- Chung Yuen-Li
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- Dash Srikanta
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- de la Cruz Verónica Pérez
- de la Fuente José
- De Martino Luisa
- De Matteis Antonella
- de Melo Edesio Jose Tenorio
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- Wang Bo
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- Wang Dong
- Wang Fen
- Wang Fuxin
- Wang Guanghui
- Wang Hai-Jie
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- Wang Hong-Gang
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- Wang Horng-Dar
- Wang Jing
- Wang Junjun
- Wang Mei
- Wang Mei-Qing
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- Wang Peng
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- Wang Shuo
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- Wang Xiao-Jia
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- Wang Yipeng
- Wang Yu
- Wang Yu Tian
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- Wang Zhi-Nong
- Wappner Pablo
- Ward Carl
- Ward Diane McVey
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- Weekes Colin D.
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- Weis Simone Nardin
- Wen Longping
- Wen Xin
- Wen Yunfei
- Westermann Benedikt
- Weyand Cornelia M.
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- Whitworth Alexander J.
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- Wild Franziska
- Wildenberg Manon E.
- Wileman Tom
- Wilkinson Deepti Srinivas
- Wilkinson Simon
- Willbold Dieter
- Williams Chris
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- Williamson Peter R.
- Winklhofer Konstanze F.
- Witkin Steven S.
- Wohlgemuth Stephanie E.
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- Xiong Yuyan
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- Xu Congfeng
- Xu Feng
- Xu Haoxing
- Xu Hongwei
- Xu Jian
- Xu Jianzhen
- Xu Jinxian
- Xu Liang
- Xu Xiaolei
- Xu Yangqing
- Xu Ye
- Xu Zhi-Xiang
- Xu Ziheng
- Xue Yu
- Yamada Takahiro
- Yamamoto Ai
- Yamanaka Koji
- Yamashina Shunhei
- Yamashiro Shigeko
- Yan Bing
- Yan Bo
- Yan Xianghua
- Yan Zhen
- Yanagi Yasuo
- Yang Dun-Sheng
- Yang Jin-Ming
- Yang Liu
- Yang Minghua
- Yang Pei-Ming
- Yang Peixin
- Yang Qian
- Yang Wannian
- Yang Wei Yuan
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yang Zhifen
- Yang Zhihong
- Yao Meng-Chao
- Yao Pamela J.
- Yao Xiaofeng
- Yao Zhenyu
- Yao Zhiyuan
- Yasui Linda S.
- Ye Mingxiang
- Yedvobnick Barry
- Yeganeh Behzad
- Yeh Elizabeth S.
- Yeyati Patricia L.
- Yi Fan
- Yi Long
- Yin Xiao-Ming
- Yip Calvin K.
- Yoo Yeong-Min
- Yoo Young Hyun
- Yoon Seung-Yong
- Yoshida Ken-Ichi
- Yoshimori Tamotsu
- Young Ken H.
- Yu Huixin
- Yu Jane J.
- Yu Jin-Tai
- Yu Jun
- Yu Li
- Yu W. Haung
- Yu Xiao-Fang
- Yu Zhengping
- Yuan Junying
- Yuan Zhi-Min
- Yue Beatrice Y. J. T.
- Yue Jianbo
- Yue Zhenyu
- Zacks David N.
- Zacksenhaus Eldad
- Zaffaroni Nadia
- Zaglia Tania
- Zakeri Zahra
- Zecchini Vincent
- Zeng Jinsheng
- Zeng Min
- Zeng Qi
- Zervos Antonis S.
- Zhang Donna D.
- Zhang Fan
- Zhang Guo
- Zhang Guo-Chang
- Zhang Hao
- Zhang Hong
- Zhang Hongbing
- Zhang Jian
- Zhang Jiangwei
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Li
- Zhang Lin
- Zhang Long
- Zhang Ming-Yong
- Zhang Xiangnan
- Zhang Xu Dong
- Zhang Yan
- Zhang Yang
- Zhang Yanjin
- Zhang Yingmei
- Zhang Yunjiao
- Zhao Mei
- Zhao Wei-Li
- Zhao Xiaonan
- Zhao Yan G.
- Zhao Ying
- Zhao Yongchao
- Zhao Yu-Xia
- Zhao Zhendong
- Zhao Zhizhuang J.
- Zheng Dexian
- Zheng Xi-Long
- Zheng Xiaoxiang
- Zhivotovsky Boris
- Zhong Qing
- Zhou Guang-Zhou
- Zhou Guofei
- Zhou Huiping
- Zhou Shu-Feng
- Zhou Xu-Jie
- Zhu Hongxin
- Zhu Hua
- Zhu Wei-Guo
- Zhu Wenhua
- Zhu Xiao-Feng
- Zhu Yuhua
- Zhuang Shi-Mei
- Zhuang Xiaohong
- Ziparo Elio
- Zois Christos E.
- Zoladek Teresa
- Zong Wei-Xing
- Zorzano Antonio
- Zughaier Susu M.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2016
- Field of study
non present
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- Author
- Abdelmohsen Kotb
- Abe Akihisa
- Abedin Md Joynal
- Abeliovich Hagai
- Adachi Hiroaki
- Adams Christopher M.
- Adams Peter D.
- Adeli Khosrow
- Adhihetty Peter J.
- Adler Sharon G.
- Agam Galila
- Agarwal Rajesh
- Aghi Manish K.
- Agnello Maria
- Agostinis Patrizia
- Aguilar Patricia V.
- Aguirre-Ghiso Julio
- Airoldi Edoardo M.
- Ait-Si-Ali Slimane
- Akematsu Takahiko
- Akporiaye Emmanuel T.
- Al-Rubeai Mohamed
- Albaiceta Guillermo M.
- Albanese Chris
- Albani Diego
- Albert Matthew L.
- Aldudo Jesus
- Alguel Hana
- Alirezaei Mehrdad
- Alloza Iraide
- Almasan Alexandru
- Almonte-Beceril Maylin
- Alnemri Emad S.
- Alonso Covadonga
- Altan-Bonnet Nihal
- Altieri Dario C.
- Alvarez Silvia
- Alvarez-Erviti Lydia
- Alves Sandro
- Amadoro Giuseppina
- Amano Atsuo
- Amantini Consuelo
- Ambrosio Santiago
- Amelio Ivano
- Amer Amal O.
- Amessou Mohamed
- Amon Angelika
- An Zhenyi
- Ana Gonzalez-Polo Rosa
- Anania Frank A.
- Andersen Stig U.
- Andley Usha P.
- Andreadi Catherine K.
- Andrieu-Abadie Nathalie
- Anel Alberto
- Ann David K.
- Anoopkumar-Dukie Shailendra
- Antonioli Manuela
- Aoki Hiroshi
- Apostolova Nadezda
- Aquila Saveria
- Aquilano Katia
- Araki Koichi
- Arama Eli
- Aranda Agustin
- Araya Jun
- Arcaro Alexandre
- Arias Esperanza
- Arimoto Hirokazu
- Ariosa Aileen R.
- Armstrong Jane L.
- Arnould Thierry
- Arozena Abraham Acevedo
- Arsov Ivica
- Asanuma Katsuhiko
- Askanas Valerie
- Asselin Eric
- Atarashi Ryuichiro
- Atherton Sally S.
- Atkin Julie D.
- Attardi Laura D.
- Auberger Patrick
- Auburger Georg
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avantaggiati Maria Laura
- Avrahami Limor
- Awale Suresh
- Azad Neelam
- Bachetti Tiziana
- Backer Jonathan M.
- Bae Dong-Hun
- Bae Jae-Sung
- Bae Ok-Nam
- Bae Soo Han
- Baehrecke Eric H.
- Baek Seung-Hoon
- Baghdiguian Stephen
- Bagniewska-Zadworna Agnieszka
- Bai Hua
- Bai Jie
- Bai Xue-Yuan
- Bailly Yannick
- Balaji Kithiganahalli Narayanaswamy
- Balduini Walter
- Ballabio Andrea
- Balzan Rena
- Banerjee Rajkumar
- Banhegyi Gabor
- Bao Haijun
- Barbato Daniele Lettieri
- Barbeau Benoit
- Barrachina Maria D.
- Barreiro Esther
- Bartel Bonnie
- Bartolome Alberto
- Bassham Diane C.
- Bassi Maria Teresa
- Bast Robert C., Jr.
- Basu Alakananda
- Batista Maria Teresa
- Batoko Henri
- Battino Maurizio
- Bauckman Kyle
- Baumgarner Bradley L.
- Bayer K. Ulrich
- Beale Rupert
- Beaulieu Jean-Francois
- Beck George R., Jr.
- Becker Christoph
- Beckham J. David
- Bedard Pierre-Andre
- Bednarski Patrick J.
- Begley Thomas J.
- Behl Christian
- Behrends Christian
- Behrens Georg M. N.
- Behrns Kevin E.
- Bejarano Eloy
- Belaid Amine
- Belleudi Francesca
- Benard Giovanni
- Berchem Guy
- Bergamaschi Daniele
- Bergami Matteo
- Berkhout Ben
- Berliocchi Laura
- Bernard Amelie
- Bernard Monique
- Bernassola Francesca
- Bertolotti Anne
- Bess Amanda S.
- Besteiro Sebastien
- Bettuzzi Saverio
- Bhalla Savita
- Bhattacharyya Shalmoli
- Bhutia Sujit K.
- Biagosch Caroline
- Bianchi Michele Wolfe
- Biard-Piechaczyk Martine
- Billes Viktor
- Bincoletto Claudia
- Bingol Baris
- Bird Sara W.
- Bitoun Marc
- Bjedov Ivana
- Blackstone Craig
- Blanc Lionel
- Blanco Guillermo A.
- Blomhoff Heidi Kiil
- Boada-Romero Emilio
- Boeckler Stefan
- Boes Marianne
- Boesze-Battaglia Kathleen
- Boise Lawrence H.
- Bolino Alessandra
- Boman Andrea
- Bonaldo Paolo
- Bordi Matteo
- Bosch Jurgen
- Botana Luis M.
- Botti Joelle
- Bou German
- Bouche Marina
- Bouchecareilh Marion
- Boucher Marie-Josee
- Boulton Michael E.
- Bouret Sebastien G.
- Boya Patricia
- Boyer-Guittaut Michaeel
- Bozhkov Peter V.
- Brady Nathan
- Braga Vania M. M.
- Brancolini Claudio
- Braus Gerhard H.
- Bravo-San Pedro Jose M.
- Brennan Lisa A.
- Bresnick Emery H.
- Bressan Queiroz de Figueiredo Regina Celia
- Brest Patrick
- Bridges Dave
- Bringer Marie-Agnes
- Brini Marisa
- Brito Glauber C.
- Brodin Bertha
- Brookes Paul S.
- Brown Eric J.
- Brown Karen
- Broxmeyer Hal E.
- Bruhat Alain
- Brum Patricia Chakur
- Brumell John H.
- Brunetti-Pierri Nicola
- Bryson-Richardson Robert J.
- Buch Shilpa
- Buchan Alastair M.
- Budak Hikmet
- Buetikofer Peter
- Bulavin Dmitry V.
- Bultman Scott J.
- Bultynck Geert
- Bumbasirevic Vladimir
- Burelle Yan
- Burke Robert E.
- Burmeister Margit
- Caberlotto Laura
- Cadwell Ken
- Cahova Monika
- Cai Dongsheng
- Cai Jingjing
- Cai Qian
- Calatayud Sara
- Camougrand Nadine
- Campanella Michelangelo
- Campbell Grant R.
- Campbell Matthew
- Campello Silvia
- Candau Robin
- Caniggia Isabella
- Cantoni Lavinia
- Cao Lizhi
- Caplan Allan B.
- Caraglia Michele
- Cardinali Claudio
- Cardoso Sandra Morais
- Carew Jennifer S.
- Carleton Laura A.
- Carlin Cathleen R.
- Carloni Silvia
- Carlsson Sven R.
- Carmona-Gutierrez Didac
- Carneiro Leticia A. M.
- Carnevali Oliana
- Carra Serena
- Carrier Alice
- Carroll Bernadette
- Casas Caty
- Casas Josefina
- Cassinelli Giuliana
- Castets Perrine
- Castro-Obregon Susana
- Cavallini Gabriella
- Ceccherini Isabella
- Cecconi Francesco
- Cederbaum Arthur I.
- Cena Valentin
- Cenci Simone
- Cerella Claudia
- Cervia Davide
- Cetrullo Silvia
- Chaachouay Hassan
- Chae Han-Jung
- Chagin Andrei S.
- Chai Chee-Yin
- Chakrabarti Gopal
- Chamilos Georgios
- Chan Edmond Y. W.
- Chan Matthew T. V.
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- Weis Simone Nardin
- Wen Longping
- Wen Xin
- Wen Yunfei
- Westermann Benedikt
- Weyand Cornelia M.
- White Anthony R.
- White Eileen
- Whitton J. Lindsay
- Whitworth Alexander J.
- Wiels Joelle
- Wild Franziska
- Wildenberg Manon E.
- Wileman Tom
- Wilkinson Deepti Srinivas
- Wilkinson Simon
- Willbold Dieter
- Williams Chris
- Williams Katherine
- Williamson Peter R.
- Winklhofer Konstanze F.
- Witkin Steven S.
- Wohlgemuth Stephanie E.
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- Wong G. William
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- Wu Defeng
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- Wu Jian
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- Xia Weiliang
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- Xiao Wuhan
- Xie Chuan-Ming
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xiong Yuyan
- Xu Chuanshan
- Xu Congfeng
- Xu Feng
- Xu Haoxing
- Xu Hongwei
- Xu Jian
- Xu Jianzhen
- Xu Jinxian
- Xu Liang
- Xu Xiaolei
- Xu Yangqing
- Xu Ye
- Xu Zhi-Xiang
- Xu Ziheng
- Xue Yu
- Yamada Takahiro
- Yamamoto Ai
- Yamanaka Koji
- Yamashina Shunhei
- Yamashiro Shigeko
- Yan Bing
- Yan Bo
- Yan Xianghua
- Yan Zhen
- Yanagi Yasuo
- Yang Dun-Sheng
- Yang Jin-Ming
- Yang Liu
- Yang Minghua
- Yang Pei-Ming
- Yang Peixin
- Yang Qian
- Yang Wannian
- Yang Wei Yuan
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yang Zhifen
- Yang Zhihong
- Yao Meng-Chao
- Yao Pamela J.
- Yao Xiaofeng
- Yao Zhenyu
- Yao Zhiyuan
- Yasui Linda S.
- Ye Mingxiang
- Yedvobnick Barry
- Yeganeh Behzad
- Yeh Elizabeth S.
- Yeyati Patricia L.
- Yi Fan
- Yi Long
- Yin Xiao-Ming
- Yip Calvin K.
- Yoo Yeong-Min
- Yoo Young Hyun
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- Yoshida Ken-Ichi
- Yoshimori Tamotsu
- Young Ken H.
- Yu Huixin
- Yu Jane J.
- Yu Jin-Tai
- Yu Jun
- Yu Li
- Yu W. Haung
- Yu Xiao-Fang
- Yu Zhengping
- Yuan Junying
- Yuan Zhi-Min
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- Yue Jianbo
- Yue Zhenyu
- Zacks David N.
- Zacksenhaus Eldad
- Zaffaroni Nadia
- Zaglia Tania
- Zakeri Zahra
- Zecchini Vincent
- Zeng Jinsheng
- Zeng Min
- Zeng Qi
- Zervos Antonis S.
- Zhang Donna D.
- Zhang Fan
- Zhang Guo
- Zhang Guo-Chang
- Zhang Hao
- Zhang Hong
- Zhang Hong
- Zhang Hongbing
- Zhang Jian
- Zhang Jian
- Zhang Jiangwei
- Zhang Jianhua
- Zhang Jing-pu
- Zhang Li
- Zhang Lin
- Zhang Lin
- Zhang Long
- Zhang Ming-Yong
- Zhang Xiangnan
- Zhang Xu Dong
- Zhang Yan
- Zhang Yang
- Zhang Yanjin
- Zhang Yingmei
- Zhang Yunjiao
- Zhao Mei
- Zhao Wei-Li
- Zhao Xiaonan
- Zhao Yan G.
- Zhao Ying
- Zhao Yongchao
- Zhao Yu-Xia
- Zhao Zhendong
- Zhao Zhizhuang J.
- Zheng Dexian
- Zheng Xi-Long
- Zheng Xiaoxiang
- Zhivotovsky Boris
- Zhong Qing
- Zhou Guang-Zhou
- Zhou Guofei
- Zhou Huiping
- Zhou Shu-Feng
- Zhou Xu-Jie
- Zhu Hongxin
- Zhu Hua
- Zhu Wei-Guo
- Zhu Wenhua
- Zhu Xiao-Feng
- Zhu Yuhua
- Zhuang Shi-Mei
- Zhuang Xiaohong
- Ziparo Elio
- Zois Christos E.
- Zoladek Teresa
- Zong Wei-Xing
- Zorzano Antonio
- Zughaier Susu M.
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
- Apostolova Nadezda
- Araki Toshiyuki
- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
- Araujo Wagner L
- Araya Jun
- Arden Catherine
- Arevalo Maria-Angeles
- Arguelles Sandro
- Arias Esperanza
- Arikkath Jyothi
- Arimoto Hirokazu
- Ariosa Aileen R
- Armstrong-James Darius
- Arnaune-Pelloquin Laetitia
- Aroca Angeles
- Arroyo Daniela S
- Arsov Ivica
- Artero Ruben
- Asaro Dalia Maria Lucia
- Aschner Michael
- Ashrafizadeh Milad
- Ashur-Fabian Osnat
- Atanasov Atanas G
- Au Alicia K
- Auberger Patrick
- Auner Holger W
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avalos Yenniffer
- Aveic Sanja
- Aveleira Celia Alexandra
- AvinWittenberg Tamar
- Aydin Yucel
- Ayton Scott
- Ayyadevara Srinivas
- Azzopardi Maria
- Baba Misuzu
- Backer Jonathan M
- Backues Steven K
- Bae Dong-Hun
- Bae Ok-Nam
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- Baehrecke Eric H
- Baek Ahruem
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- Bagetta Giacinto
- Bagniewska-Zadworna Agnieszka
- Bai Hua
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- Bai Xiyuan
- Bai Yidong
- Bairagi Nandadulal
- Baksi Shounak
- Balazadeh Salma
- Balbi Teresa
- Baldari Cosima T
- Balduini Walter
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- Bandopadhyay Rina
- Banerjee Sreeparna
- Banerjee Sulagna
- Bao Yan
- Baptista Mauricio S
- Baracca Alessandra
- Barbati Cristiana
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- Barila Daniela
- Barlow Peter G
- Barmada Sami J
- Barreiro Esther
- Barrera Miguel Calvo-Rubio
- Barreto George E
- Bartek Jiri
- Bartel Bonnie
- Bartolome Alberto
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- Basagoudanavar Suresh H
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- Basu Alakananda
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- Bei Roberto
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- Bellarosa Cristina
- Belleudi Francesca
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- Bello-Morales Raquel
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- Benitez Bruno A
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- Berchtold Martin W
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- Bhaskar Kiran
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- Bhattacharya Resham
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- Carter A Brent
- Carvalho Andreia Neves
- Casanova Magali
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- Castillo Eliseo F
- Castillo Karen
- Castillo-Lluva Sonia
- Castoldi Francesca
- Castori Marco
- Castro Ariel F
- Castro-Caldas Margarida
- Castro-Hernandez Javier
- Castro-Obregon Susana
- Catz Sergio D
- Cavadas Claudia
- Cavaliere Federica
- Cavallini Gabriella
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- Cenci Simone
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- Cervia Davide
- Cetintas Vildan Bozok
- Cetrullo Silvia
- Chae Han-Jung
- Chagin Andrei S
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- Chakrabarti Oishee
- Chakraborty Tapas
- Chakraborty Trinad
- Chami Mounia
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- Chatterjee Samrat
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- Chaudhary Anu
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- Chaum Edward
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- Checler Frederic
- Cheetham Michael E
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- Chen Wei
- Chen Weiqiang
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- Chen Xiong-Wen
- Chen Xu
- Chen Yan
- Chen Ye-Guang
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- Chen Yue-Qin
- Chen YuJen
- Chen Zhefan Stephen
- Chen Zhi
- Chen Zhi-Hua
- Chen Zhijian J
- Chen Zhixiang
- Chen Zhong
- Cheng Hanhua
- Cheng Jun
- Cheng Shi-Yuan
- Cheng Wei
- Cheng Xiaodong
- Cheng Xiu-Tang
- Cheng Yiyun
- Cheng Zhiyong
- Cheong Heesun
- Cheong Jit Kong
- Chernyak Boris V
- Cherry Sara
- Cheung Chi Fai Randy
- Cheung Chun Hei Antonio
- Cheung King-Ho
- Chevet Eric
- Chi Richard J
- Chiang Alan Kwok Shing
- Chiaradonna Ferdinando
- Chiarelli Roberto
- Chiariello Mario
- Chica Nathalia
- Chiocca Susanna
- Chiong Mario
- Chiou Shih-Hwa
- Chiramel Abhilash I
- Chiurchiu Valerio
- Cho Dong-Hyung
- Choe Seong-Kyu
- Choi Augustine MK
- Choi Mary E
- Choudhury Kamalika Roy
- Chow Norman S
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- Chua Jason P
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- Colombo Maria I
- Colon-Ramos Daniel A
- Combaret Lydie
- Comincini Sergio
- Cominetti Marcia R
- Compagnoni Giacomo Monzio
- Consiglio Antonella
- Conte Andrea
- Conti Fabrizio
- Contu Viorica Raluca
- Cookson Mark R
- Coombs Kevin M
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- Corasaniti Maria Tiziana
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- Mareninova Olga A
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- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types
- Author
- A. Gordon Robertson
- Aaron Bossler
- Ad Gillis
- Adam Abeshouse
- Adam Kibel
- Adam R. Metwalli
- Adhemar Longatto-Filho
- Adrian Ally
- Adrian Clipca
- Ady Kendler
- Agostino De Rose
- Ajith Sankarankuty
- Alain Bergeron
- Alain Piché
- Alan H. Bryce
- Alan P. Hoyle
- Alan Pickens
- Albert J. Kovatich
- Ales Vicha
- Alessandro Perin
- Alex Boussioutas
- Alexander J. Lazar
- Alexey Shabunin
- Alexis Sharp
- Alison Kastl
- Amy Chen
- Amy Davis
- Amy H. Perou
- Ana C. de Carvalho
- Ana Maria Angulo Gonzalez
- Anant A. Agrawal
- Andre L. Carvalho
- Andrea Haddad
- Andreas Unterberg
- Andreas von Deimling
- Andrei Malykh
- Andrew Berchuck
- Andrew Burnette
- Andrew D. Cherniack
- Andrew E. Sloan
- Andrew J. Mungall
- Andrew K. Godwin
- Andrew Spillane
- Angel Arnaout
- Angela Tam
- Angeles Secord
- Angelica Ochoa
- Anil Korkut
- Anil Sood
- Anna Antenucci
- Anne Breggia
- Anne Tsao
- Anne-Marie Mes-Masson
- Anne-Paule Gimenez-Roqueplo
- Antonia Sepulveda
- Antonio Jimeno
- Anuradha Gopalan
- Apurva M. Hegde
- Ardene Noss
- Armando López Guillermo
- Armaz Mariamidze
- Arndt Hartmann
- Arthur Tischler
- Arvind Rao
- Ashley Fehrenbach
- Ashton C. Berger
- Assunta De Rienzo
- Augustin Luna
- Bahavna Kumar
- Barry S. Taylor
- Benito Campos
- Benjamin E. Gross
- Bernard Kohl
- Bernard Têtu
- Bernd Wullich
- Beth Hermes
- Beth Y. Karlan
- Bettina Drake
- Bhuvanesh Singh
- Bianca Pollo
- Bita Esmaeli
- Bogdan Czerniak
- Bradley M. Broom
- Brady Bernard
- Brenda Deyarmin
- Brenda Hernandez
- Brenda Rabeno
- Brian Patrick O’Neill
- Brian Van Tine
- Bruce Robinson
- Bui Duc Phu
- Candace Carter
- Candace Shelton
- Carl Morrison
- Carl Simon Shelley
- Carlo Bifulco
- Carlos Gilberto Carlotti Jr.
- Carmen Behrens
- Carol Bradford
- Carol Farver
- Caroline Larson
- Carolyn M. Hutter
- Carrie Cibulskis
- Cassaundra Shipman
- Catherine Moser
- Cathy Brewer
- Cathy D. Vocke
- Cathy Schilero
- Catrina C. Fronick
- Cesar Moran
- Chad J. Creighton
- Chandra Goparaju
- Chandrajit P. Raut
- Charles Guo
- Charles M. Perou
- Charles N. Landen
- Cheng Fan
- Chiara Calatozzolo
- Chris Andry
- Chris Sander
- Christel Herold-Mende
- Christin Jungk
- Christina Yau
- Christine Stoehr
- Christopher A. Miller
- Christopher Benz
- Christopher Hovens
- Christopher K. Wong
- Christopher Logothetis
- Christopher McPherson
- Christopher W. Seder
- Chu Chen
- Clement Adebamowo
- Colleen Feltmate
- Colleen M. Cebulla
- Corbin D. Jones
- Craig D. Shriver
- Cristovam Scapulatempo-Neto
- Curt H. Hagedorn
- Cyriac Kandoth
- Cyrus Mirsaidi
- D. Neil Hayes
- Daniel Crain
- Daniel Cramer
- Daniel J. Brat
- Daniel J. Weisenberger
- Daniel O. Vidal
- Daniel O’Brien
- Daniel Raymond
- Daniela Tirapelli
- Darell Bigner
- Darlene Lee
- Dave Hoon
- David A. Wheeler
- David Beer
- David Chesla
- David Huntsman
- David I. Heiman
- David J. Van Den Berg
- David Mallery
- David Nagorney
- David Rice
- Dawid Murawa
- Debra Bell
- Debyani Chakravarty
- Denise Brooks
- Dennis T. Maglinte
- Deqin Ma
- Diana Tcaciuc
- Dina Aziz
- Dirk Schadendorf
- Domenico Alvaro
- Dong M. Shin
- Donghui Tan
- Donna Morton
- Donna Muzny
- Doris M. Rassl
- Doug Voet
- Douglas A. Levine
- Ed Reznik
- Edna M. Mora Pinero
- Elaine R. Mardis
- Electron Kebebew
- Elias Campo
- Elizabeth L. Appelbaum
- Elizabeth R. Duffy
- Elizabeth Swisher
- Ellen C. Zwarthoff
- Eric Baudin
- Eric Chuah
- Eric Lipp
- Eric Thompson
- Erik Castle
- Erik Zmuda
- Erin Curley
- Erwin G. Van Meir
- Eryn M. Godwin
- Esther Korpershoek
- Eugenio Gaudio
- Eva Giné
- Eve Shinbrot
- Fadi Brimo
- Fadlo Khuri
- Federico Valdivieso
- Fedor Moiseenko
- Feixiong Cheng
- Felice Giuliante
- Felicia Williams
- Felix Beuschlein
- Fengmei Zhao
- Florencia Que
- Francesco DiMeco
- Francesco Facciolo
- Francis Carey
- Francisco Sanchez-Vega
- Fred Saad
- Funda Meric-Bernstam
- Gabriel Sica
- Gad Getz
- Gaetano Finocchiaro
- Galen F. Gao
- Galiya Setdikova
- Gavin Ha
- Gene Barnett
- George Manikhas
- George Thomas
- Georgina Long
- Ghenadie Gorincioi
- Gianluca Grazi
- Ginette McKercher
- Glenn Bubley
- Gloria Petersen
- Gordon B. Mills
- Gordon Saksena
- Graham Mann
- Gregory Wolf
- Guido Carpino
- Guido Sauter
- Hai Hu
- Hailei Zhang
- Han Liang
- Hani Gabra
- Hanina Hibshoosh
- Hannah Yang
- Hans Stoop
- Harman Sekhon
- HarshaVardhan Doddapaneni
- Hartmut Juhl
- Hartwig Huland
- Harvey Pass
- Heather K. Schmidt
- Heidi J. Sofia
- Helge Taubert
- Henri Timmers
- Henrique C.S. Silveira
- Hikmat Al-Ahmadie
- Hojabr Kakavand
- Hongxin Zhang
- Hongzheng Zhang
- Houtan Noushmehr
- Howard Colman
- Howard G. Rosenthal
- Howard Zaren
- Hui Shen
- Huihui Fan
- Huyen Dinh
- Iakovina Alexopoulou
- Ian Forgie
- Ian Yang
- Ignacio Wistuba
- Ilya Shmulevich
- Ina Felau
- Inga Chemencedji
- Ino de Bruijn
- Irina Caraman
- Irina Stancul
- J. Bradley Elder
- J. Leigh Fantacone-Campbell
- J. Todd Auman
- Jacqueline E. Schein
- Jaegil Kim
- Jaffer A. Ajani
- James Catto
- James Lang
- James Luketich
- James Palacino
- James Powers
- James Wilmott
- Janae V. Simons
- Jay Bowen
- Jay Engel
- Jean C. Zenklusen
- Jean-Pierre Kocher
- Jeffey Moyer
- Jeffrey A. Borgia
- Jeffrey A. Hooke
- Jeffrey Gershenwald
- Jeffrey J. Olson
- Jeffrey Marks
- Jeffrey Roach
- Jeffry Simko
- Jenette Creaney
- Jennifer Drummond
- Jennifer Eschbacher
- Jennifer Smith
- Jens Waldmann
- Jeremy Parfitt
- Jerome Myers
- Jia Liu
- Jianhong Hu
- Jianjiong Gao
- Jiashan (Julia) Zhang
- Jiexin Zhang
- Jill S. Barnholtz-Sloan
- Jing Wang
- Jioajiao Wang
- Jireh Santibanez
- Joan Walker
- Joanna Phillips
- Jodi Harr
- Joe Hilty
- Joel Henderson
- Joel S. Parker
- Johanna Gardner
- John A. Copland
- John A. Demchok
- John A. Martignetti
- John Bartlett
- John Chabot
- John Cheville
- John DiPersio
- John Eckman
- John Houck
- John N. Weinstein
- John Thompson
- Jolanta Bondaruk
- Jonathan Melamed
- Jonathan Stretch
- Joong-Won Park
- Jordonna Fulop
- Jose Sebastião Dos Santos
- Joseph Bennett
- Joseph Galbraith
- Joseph Paulauskis
- Joshua Armenia
- Joshua M. Stuart
- José H. Fregnani
- Ju Dong Yang
- Judy Miller
- Julia Slotta-Huspenina
- Julian Hess
- Juliann Shih
- Julie M. Gastier-Foster
- Julie Martin
- Jun Li
- June M. Chan
- Jung Il Lee
- Junya Fujimoto
- Juok Cho
- Kalle Leinonen
- Kane Tse
- Karan Rai
- Karel Pacak
- Karen Devine
- Karen Mungall
- Karen Smith-McCune
- Karl-Friedrich Becker
- Karla Kopp
- Katayoon Kasaian
- Katherine A. Hoadley
- Katherine C. Sexton
- Katherine Moxley
- Kathleen Moore
- Kathy Agnew
- Kathy Smolenski
- Keith Delman
- Kelinda Tucker
- Kelly Magliocca
- Kelly Senecal
- Kenneth Lee
- Kerstin Junker
- Kerwin Shannon
- Keunsoo Ahn
- Kevin Lau
- Kevin Roggin
- Ki Chung
- Kim E. van Kessel
- Kimberley Evason
- Kivanc Birsoy
- Klaus-Peter Janssen
- Konnor La
- Koo Jeong Kang
- Kristen M. Leraas
- Kristen Shimmel
- Kwok-Shing Ng
- Kwun M. Fong
- Kyle Chang
- Kyle Covington
- Larsson Omberg
- Laura Jacobus
- Laura Rozek
- Laura S. Schmidt
- Lauren Haydu
- Laurence Desjardins
- Lawrence A. Donehower
- Laxmi Lolla
- Leendert Looijenga
- Leigh Anne Zach
- Leonid Kvecher
- Leslie Cope
- Lewis Roberts
- Li Ding
- Lihua Yu
- Liming Yang
- Linghua Wang
- Lisa Landrum
- Lisa Peterson
- Lisa Scarpace
- Lisa Wise
- Lisle E. Mose
- Liu Xi
- Lizhi Zhang
- Lois Ramondetta
- Lora Lewis
- Louis Lacombe
- Luca Mattei
- Lucia Cuppini
- Lucinda A. Fulton
- Ludmila Danilova
- Lynn Schoenfield
- Maciej Wiznerowicz
- Madhusmita Behera
- Marc Goodman
- Marc Ladanyi
- Marc Moncrieff
- Marc-Henri Stern
- Marco A. Marra
- Margaret Morgan
- Margi Sheth
- Maria Consiglia Bragazzi
- Maria Pirtac
- Maria Synott
- Mario Quintero-Aguilo
- Mark A. Rubin
- Mark Gerken
- Mark Nelson
- Mark Pool
- Mark Prince
- Mark Schiffman
- Mark Sherman
- Markus Graefen
- Marta Aymerich
- Marta Couce
- Martin Fassnacht
- Martin L. Ferguson
- Mary Iacocca
- Mary McGraw
- Massimo Mannelli
- Mathieu Latour
- Matthew Bailey
- Matthew D. Wilkerson
- Matthew G. Cordes
- Matthew G. Soloway
- Matthew L. Anderson
- Matthew Meyerson
- Melanie H. Kucherlapati
- Melissa Stanton
- Melpomeni Kasapi
- Michael Birrer
- Michael Carney
- Michael D. McLellan
- Michael Dubina
- Michael Farnell
- Michael Feldman
- Michael Ittmann
- Michael J. Liptay
- Michael Kendrick
- Michael Knudson
- Michael Mayo
- Michael Miller
- Michael Muto
- Michael Prados
- Michael Quinn
- Michael Rivera
- Michael Ryan
- Michael S. Lawrence
- Michael S. Noble
- Michael Seiler
- Michael Torbenson
- Michelle Bellair
- Mikhail Dinkin
- Mikhail Tavobilov
- Min Wang
- Mircea Cernat
- Mirella Marino
- Miruna Balasundaram
- Mitesh Borad
- Mohamed H. Abdel-Rahman
- Mohammed Milhem
- Moiz S. Bootwalla
- Monique Albert
- Moriah G. Nissan
- Myron Peto
- Nasra Giama
- Natalia Botnariuc
- Nathan A. Pennell
- Natália D. Aredes
- Neil Horowitz
- Nguyen Phi Hung
- Nguyen Van Bang
- Nguyen Viet Tien
- Niall Corcoran
- Nicholas Hayward
- Nicolas Girard
- Nicolas Wentzensen
- Nikolaus Schultz
- Nils Gehlenborg
- Nilsa C. Ramirez
- Nina Thiessen
- Noreen Dhalla
- Norman L. Lehman
- Nyasha Chambwe
- Odette Mariani
- Olga Potapova
- Olga Voronina
- Oliver Bathe
- Oluwole Olabode
- Oxana Paklina
- Pat Glenn
- Patricia D. Castro
- Patricia Swanson
- Patricia Troncoso
- Paul Drwiega
- Paul Hansen
- Paul Spellman
- Paul Wakely
- Pavana Anur
- Pawadee Lohavanichbutr
- Payal Sipahimalani
- Peggy Yena
- Pei Lin
- Peter A. Pinto
- Peter G. Smith
- Peter Hersey
- Peter R. Carroll
- Peter R. Dottino
- Peter W. Laird
- Peter Westervelt
- Phan Thi Hanh
- Pheroze Tamboli
- Philip Disaia
- Phillip H. Lai
- Phuong Nguyen
- Pierre Tennstedt
- Ping Zhu
- Piotr A. Mieczkowski
- Praveen Nair
- Qiang Sun
- Quinn T. Ostrom
- R. Houston Thompson
- Rafael Kemp
- Raina Tamakawa
- Rajiv Dhir
- Raju S. Kucherlapati
- Ramaswamy Govindan
- Rameen Beroukhim
- Randy Mandt
- Raphael Bueno
- Rashi Naresh
- Rashna Madan
- Rayleen Bowman
- Reanne Bowlby
- Rebecca Carlsen
- Rebecca Duell
- Rehan Akbani
- Renumathy Dhanasekaran
- Richard A. Gibbs
- Richard A. Moore
- Richard J. Mural
- Richard K. Wilson
- Richard Kefford
- Richard Scolyer
- Richard Thorp
- Rita Sigmund
- Ritika Kundra
- Robert C. Rintoul
- Robert Glenn
- Robert Holt
- Robert Korst
- Robert Mannel
- Robert Penny
- Robert Pilarski
- Robert S. Fulton
- Robert Sheridan
- Robert Smallridge
- Robert Stoehr
- Robert Worrell
- Roberta Merola
- Robin K. Kelley
- Robyn Saw
- Roger Kramer
- Roger McLendon
- Ronald de Krijger
- Ronald Ghossein
- Ronald Lechan
- Ronald Simon
- Ronald Warnick
- Rosemary Zuna
- Ross Berkowitz
- Rosy Singh
- Roy Tarnuzzer
- Rui M. Reis
- Rupa S. Kanchi
- Russel Postier
- Russell Broaddus
- Ruth Steele
- S. Onur Sumer
- Sabina Signoretti
- Saianand Balu
- Sally N. Adebamowo
- Sam Meier
- Samantha J. Caesar-Johnson
- Samuel Singer
- Sandra Cottingham
- Sandra Lee
- Sara Kendall
- Sara Sadeghi
- Sarah M. Phillips
- Scott Frazer
- Scott Morris
- Scott VandenBerg
- Sebastien Gilbert
- Serghei Doruc
- Serghei Stepa
- Sergio Roman-Roman
- Sergiu Mura
- Seth Force
- Shannon McCall
- Shaowu Meng
- Sharon Heath
- Sheila Reynolds
- Shishir Maithel
- Shiyun Ling
- Shouyong Peng
- Silvia Buonamici
- Sima Porten
- Simone Chevalier
- Stacey B. Gabriel
- Stefania Cuzzubbo
- Stella Somiari
- Stephen Baylin
- Steven E. Schumacher
- Steven J.M. Jones
- Steven Kalkanis
- Stuart R. Jefferys
- Sudha Chudamani
- Sue Bell
- Suresh Ramalingam
- Susan M. Staugaitis
- Suzanne Sifri
- Sven Wach
- Sylvia L. Asa
- Tao Su
- Taofeek Owonikoko
- Tara M. Lichtenberg
- Tara Skelly
- Teng Teng
- Teniola Akeredolu
- Thai Ho
- Theo Knijnenburg
- Theresa Naska
- Therese Bocklage
- Thomas Broudy
- Thomas Carey
- Thomas Flotte
- Thomas Giordano
- Thomas Smyrk
- Thorsten Schlomm
- Timothy A. Chan
- Timothy DeFreitas
- Timothy Ley
- Timothy Thompson
- Timothy Wang
- Tina Knutson
- Tina Wong
- Todd Pihl
- Tom Bodenheimer
- Tom Mikkelsen
- Tomas Zelinka
- Tony Costello
- Toshinori Hinoue
- Troy Shelton
- Tushar Patel
- Umadevi Veluvolu
- Valerie Jakrot
- Varsha Dhankani
- Vesteinn Thorsson
- Victor Reuter
- Viktoriya Korchina
- Vincenzo Cardinale
- Vishal Chandan
- Vladimir Lyadov
- W. Jeffrey Edenfield
- W. Kimryn Rathmell
- W. Marston Linehan
- Walid K. Chatila
- Walker Hale
- Walter Urba
- Wanding Zhou
- Wei Li
- Wei Zhang
- Wenbin Liu
- Wendi Barrett
- Wil Eijckenboom
- William E. Grizzle
- William G. Richards
- Witold Kycler
- Wolter Oosterhuis
- Xavier Sastre
- Xiuping Liu
- Xuan Le
- Yan Shi
- Ye Wu
- Yi Han
- Yichao Sun
- Yiling Lu
- Yingli Wolinsky
- Yuexin Liu
- Yufang Tang
- Yunhu Wan
- Yussanne Ma
- Zachary J. Heins
- Zhenlin Ju
- Zhining Wang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2018
- Field of study
Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The Cancer Genome Atlas (TCGA), and we identified 119 splicing factor genes with significant non-silent mutation patterns, including mutation over-representation, recurrent loss of function (tumor suppressor-like), or hotspot mutation profile (oncogene-like). Furthermore, RNA sequencing analysis revealed altered splicing events associated with selected splicing factor mutations. In addition, we were able to identify common gene pathway profiles associated with the presence of these mutations. Our analysis suggests that somatic alteration of genes involved in the RNA-splicing process is common in cancer and may represent an underappreciated hallmark of tumorigenesis. : Seiler et al. report that 119 splicing factor genes carry putative driver mutations over 33 tumor types in TCGA. The most common mutations appear to be mutually exclusive and are associated with lineage-independent altered splicing. Samples with these mutations show deregulation of cell-autonomous pathways and immune infiltration. Keywords: splicing, SF3B1, U2AF1, SRSF2, RBM10, FUBP1, cancer, mutatio