Characterization, synthesis, and optimization of quantum circuits over multiple-control Z\textit{Z}-rotation gates: A systematic study

We conduct a systematic study of quantum circuits composed of multiple-control $Z$-rotation (MCZR) gates as primitives, since they are widely-used components in quantum algorithms and also have attracted much experimental interest in recent years. Herein, we establish a circuit-polynomial correspondence to characterize the functionality of quantum circuits over the MCZR gate set with continuous parameters. An analytic method for exactly synthesizing such quantum circuit to implement any given diagonal unitary matrix with an optimal gate count is proposed, which also enables the circuit depth optimal for specific cases with pairs of complementary gates. Furthermore, we present a gate-exchange strategy together with a flexible iterative algorithm for effectively optimizing the depth of any MCZR circuit, which can also be applied to quantum circuits over any other commuting gate set. Besides the theoretical analysis, the practical performances of our circuit synthesis and optimization techniques are further evaluated by numerical experiments on two typical examples in quantum computing, including diagonal Hermitian operators and Quantum Approximate Optimization Algorithm (QAOA) circuits with tens of qubits, which can demonstrate a reduction in circuit depth by 33.40\% and 15.55\% on average over relevant prior works, respectively. Therefore, our methods and results provide a pathway for implementing quantum circuits and algorithms on recently developed devices.Comment: Comments are welcom

The role of ferroptosis in virus infections

Regulated cell death (RCD) is a strategy employed by host cells to defend invasions of pathogens, such as viruses and bacteria. Ferroptosis is a type of RCD characterized by excessive accumulation of iron and lipid peroxidation. While ferroptosis is primarily considered as a mechanism associated with tumorigenesis, emerging evidence begin to suggest that it may play essential role during virus infections. Recent studies illustrated that activation of ferroptosis could either induce or prohibit various types of RCDs to facilitate virus replication or evade host surveillance. More experimental evidence has demonstrated how viruses regulate ferroptosis to influence replication, transmission, and pathogenesis. This review summarizes ferroptosis-related metabolism, including iron metabolism, lipid peroxidation, and antioxidant metabolism. Furthermore, we discuss the interplay between viral infections and host ferroptosis process, with a focus on the mechanism of how viruses exploit ferroptosis for its own replication. Understanding how ferroptosis impacts virus infection can offer valuable insights into the development of effective therapeutic strategies to combat virus infections

QSYQ Attenuates Oxidative Stress and Apoptosis Induced Heart Remodeling Rats through Different Subtypes of NADPH-Oxidase

We aim to investigate the therapeutic effects of QSYQ, a drug of heart failure (HF) in clinical practice in China, on a rat heart failure (HF) model. 3 groups were divided: HF model group (LAD ligation), QSYQ group (LAD ligation and treated with QSYQ), and sham-operated group. After 4 weeks, rats were sacrificed for cardiac injury measurements. Rats with HF showed obvious histological changes including necrosis and inflammation foci, elevated ventricular remodeling markers levels(matrix metalloproteinases-2, MMP-2), deregulated ejection fraction (EF) value, increased formation of oxidative stress (Malondialdehyde, MDA), and up-regulated levels of apoptotic cells (caspase-3, p53 and tunnel) in myocardial tissue. Treatment of QSYQ improved cardiac remodeling through counter-acting those events. The improvement of QSYQ was accompanied with a restoration of NADPH oxidase 4 (NOX4) and NADPH oxidase 2 (NOX2) pathways in different patterns. Administration of QSYQ could attenuate LAD-induced HF, and AngII-NOX2-ROS-MMPs pathway seemed to be the critical potential targets for QSYQ to reduce the remodeling. Moreover, NOX4 was another key targets to inhibit the p53 and Caspase3, thus to reduce the hypertrophy and apoptosis, and eventually provide a synergetic cardiac protective effect

Simplified Madymo Seated Human Body Model for Motion Comfort Evaluation

People need to have a comfortable experience in vehicles nowadays. However, they are continuously exposed to vibrations from the vehicle. Madymo active human models (AHM) can be used for comfort analysis and to learn how vibrations influence the human body in several aspects. However, existing AHM are very time-consuming due to their complexity, and the correspondence with human comfort data is only reasonable. In order to more effectively analyze motion comfort, a computationally efficient simplified human model (SHM) is developed and validated. The human body model has 36 degrees of freedom (DoF) considering the following segments: pelvis, two thighs, two lower legs, two feet, lower torso, upper torso and head. The model is validated in fore-aft, lateral and vertical vibrations. The model's postural stabilization parameters are tuned manually, by gradient search and grid search in sequence. Manually tuning gives a group of initial values of parameters for further optimization. According to the results, failure of the gradient search illustrates that this optimization problem is non-smooth. At the same time, grid search gives a relatively better result but also shows that the current cost function does not perfectly represent a good fit and needs improvement. A comparison between AHM and the SHM shows that the SHM has a similar or even better fit for most signals while being a largest factor 116 faster. A comparison of parameters between SHM and multibody human models in the literature shows that the structure of models affects the values of the same parameters. A comparison of different time steps illustrates that shorter time step does not necessarily give higher accuracy for this SHM. Suggestions such as adding muscles and changing body shapes are given for further improvement.Mechanical Engineerin

GSARNN Code and Data

GSARNN Code, Simulated Data and Argo Dat

Optimization of the Liquid Steel Flow Behavior in the Tundish through Water Model Experiment, Numerical Simulation and Industrial Trial

A reasonable tundish flow behavior could improve liquid steel cleanliness by promoting floating and removal of the inclusions. The flow behaviors of the tundish could be obtained by water model experiments and numerical simulations, respectively. However, the difference in density between the tracer and water in the experiment can contribute to notable errors. A new type of tracer, which is a mixture of potassium chloride (KCl) and ethanol, was proposed in this study to reduce the errors. The numerical simulation model was validated by the experimental data and its error was below 2%. By comparing the flow behaviors in seven tundishes with different inner structures obtained by simulation, it is found that the C1 can significantly reduce the dead volume ratio and C4 can improve the uniformity of liquid steel charged though each outlet. The structural strength of the baffle in C1 scheme was not considered, resulting in a crack of the baffle in the industrial trial. Industrial trials of the molten steel flow in the C4-based tundish were conducted and reported a reduction of 43.81% in the inclusions over the prototype

Optimization of the Liquid Steel Flow Behavior in the Tundish through Water Model Experiment, Numerical Simulation and Industrial Trial

A reasonable tundish flow behavior could improve liquid steel cleanliness by promoting floating and removal of the inclusions. The flow behaviors of the tundish could be obtained by water model experiments and numerical simulations, respectively. However, the difference in density between the tracer and water in the experiment can contribute to notable errors. A new type of tracer, which is a mixture of potassium chloride (KCl) and ethanol, was proposed in this study to reduce the errors. The numerical simulation model was validated by the experimental data and its error was below 2%. By comparing the flow behaviors in seven tundishes with different inner structures obtained by simulation, it is found that the C1 can significantly reduce the dead volume ratio and C4 can improve the uniformity of liquid steel charged though each outlet. The structural strength of the baffle in C1 scheme was not considered, resulting in a crack of the baffle in the industrial trial. Industrial trials of the molten steel flow in the C4-based tundish were conducted and reported a reduction of 43.81% in the inclusions over the prototype