Multicritical Points of Potts Spin Glasses on the Triangular Lattice

We predict the locations of several multicritical points of the Potts spin glass model on the triangular lattice. In particular, continuous multicritical lines, which consist of multicritical points, are obtained for two types of two-state Potts (i.e., Ising) spin glasses with two- and three-body interactions on the triangular lattice. These results provide us with numerous examples to further verify the validity of the conjecture, which has succeeded in deriving highly precise locations of multicritical points for several spin glass models. The technique, called the direct triangular duality, a variant of the ordinary duality transformation, directly relates the triangular lattice with its dual triangular lattice in conjunction with the replica method.Comment: 18 pages, 2, figure

Structural complexities in the Alishan area of the Taiwan fold-and-thrust belt inherited from the margin's shelf-slope transition

This article is subject to a CC Attribution 3.0 License.The Alishan area of Taiwan includes a sector of the fold-and-thrust belt that spans the transition from the platform with full thickness of the Eurasian continental margin in the north to the thinning crust of its slope in the south. This part of the fold-and-thrust belt with the highest elevations includes important along-strike changes in structure, stratigraphy, and seismic velocities. Here we present the results of new geological mapping from which we build geological cross sections both across and along the regional structural trend. Fault contour, stratigraphic cut-off, and branch line maps provide 3-D consistency between the cross sections. Minimum shortening is estimated to be 15 km, with displacement overall to the northwest. A P wave velocity model helps constrain the structure at depth by providing insight into the possible rock units that are present there. P wave velocities of > 5.2 km/s point toward the presence of basement rocks in the shallow subsurface throughout much of the south-eastern part of the area, forming a basement culmination. The changes in strike of thrusts and fold axial traces, the changing elevation of thrusts and stratigraphic contacts, and the growing importance of Middle Miocene sediments that take place from north to south are interpreted to be associated with a roughly northeast striking lateral structure coincident with the northern flank of this basement culmination. These transverse structures appear to be associated with the inversion of Eocene- and Miocene-age extensional faults, deeply rooted in the pre Cenozoic basement that were along what was the shelf-slope transition in the Early Oligocene. Inversion causes uplift of the margin sediments and their higher P wave velocity basement during Pliocene-Pleistocene thrusting.Peer Reviewe

Interventions for post-stroke fatigue

BACKGROUND: Post-stroke fatigue (PSF) is a common and distressing problem after stroke. The best ways to prevent or treat PSF are uncertain. Several different interventions can be argued to have a rational basis. OBJECTIVES: To determine whether, among people with stroke, any intervention reduces the proportion of people with fatigue, fatigue severity, or both; and to determine the effect of intervention on health-related quality of life, disability, dependency and death, and whether such intervention is cost effective. SEARCH METHODS: We searched the Cochrane Stroke Group Trials Register (last searched May 2014), Cochrane Central Register of Controlled Trials (The Cochrane Library, 2014, Issue 4), MEDLINE (1950 to May 2014), EMBASE (1980 to May 2014), CINAHL (1982 to May 2014), AMED (1985 to May 2014), PsycINFO (1967 to May 2014), Digital Dissertations (1861 to May 2014), British Nursing Index (1985 to May 2014), PEDro (searched May 2014) and PsycBITE (searched May 2014). We also searched four ongoing trials registries, scanned reference lists, performed citation tracking of included trials and contacted experts. SELECTION CRITERIA: Two review authors independently scrutinised all titles and abstracts and excluded obviously irrelevant studies. We obtained the full texts for potentially relevant studies and three review authors independently applied the inclusion criteria. We included randomised controlled trials (RCTs) that compared an intervention with a control, or compared different interventions for PSF. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data and assessed risk of bias for each included trial. The primary outcomes were severity of fatigue, or proportion of people with fatigue after treatment. We performed separate analyses for trials investigating efficacy in treating PSF, trials investigating efficacy in preventing PSF and trials not primarily investigating efficacy in PSF but which reported fatigue as an outcome. We pooled results from trials that had a control arm. For trials that compared different potentially active interventions without a control arm, we performed analyses for individual trials without pooling.We calculated standardised mean difference (SMD) as the effect size for continuous outcomes and risk ratio (RR) for dichotomous outcomes. We pooled the results using a random-effects model and assessed heterogeneity using the I(2) statistic. We performed separate subgroup analyses for pharmacological and non-pharmacological interventions. We also performed sensitivity analyses to assess the influence of methodological quality. MAIN RESULTS: We retrieved 12,490 citations, obtained full texts for 58 studies and included 12 trials (three from the 2008 search and nine from the 2014 search) with 703 participants. Eight trials primarily investigated the efficacy in treating PSF, of which six trials with seven comparisons provided data suitable for meta-analysis (five pharmacological interventions: fluoxetine, enerion, (-)-OSU6162, citicoline and a combination of Chinese herbs; and two non-pharmacological interventions: a fatigue education programme and a mindfulness-based stress reduction programme). The fatigue severity was lower in the intervention groups than in the control groups (244 participants, pooled SMD -1.07, 95% confidence interval (CI) -1.93 to -0.21), with significant heterogeneity between trials (I(2) = 87%, degrees of freedom (df) = 6, P value < 0.00001). The beneficial effect was not seen in trials that had used adequate allocation concealment (two trials, 89 participants, SMD -0.38, 95% CI -0.80 to 0.04) or trials that had used adequate blinding of outcome assessors (four trials, 198 participants, SMD -1.10, 95% CI -2.31 to 0.11).No trial primarily investigated the efficacy in preventing PSF.Four trials (248 participants) did not primarily investigate the efficacy on fatigue but other symptoms after stroke. None of these interventions showed any benefit on reducing PSF, which included tirilazad mesylate, continuous positive airway pressure for sleep apnoea, antidepressants and a self management programme for recovery from chronic diseases. AUTHORS' CONCLUSIONS: There was insufficient evidence on the efficacy of any intervention to treat or prevent fatigue after stroke. Trials to date have been small and heterogeneous, and some have had a high risk of bias. Some of the interventions described were feasible in people with stroke, but their efficacy should be investigated in RCTs with a more robust study design and adequate sample sizes

The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain

The mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulates genome architecture at a genome-wide level

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

AbstractConverging evidence suggests that the accumulation of cerebral amyloid β-protein (Aβ) in Alzheimer's disease (AD) reflects an imbalance between the production and degradation of this self-aggregating peptide. Upregulation of proteases that degrade Aβ thus represents a novel therapeutic approach to lowering steady-state Aβ levels, but the consequences of sustained upregulation in vivo have not been studied. Here we show that transgenic overexpression of insulin-degrading enzyme (IDE) or neprilysin (NEP) in neurons significantly reduces brain Aβ levels, retards or completely prevents amyloid plaque formation and its associated cytopathology, and rescues the premature lethality present in amyloid precursor protein (APP) transgenic mice. Our findings demonstrate that chronic upregulation of Aβ-degrading proteases represents an efficacious therapeutic approach to combating Alzheimer-type pathology in vivo

Coronavirus disease 2019 among pregnant Chinese women : case series data on the safety of vaginal birth and breastfeeding

Funding Information: National Key Research and Development Program of China. Grant Numbers: 2016YFC1000203, 2018YFC1002804Peer reviewedPublisher PD

Expression quantitative trait loci are highly sensitive to cellular differentiation state

Blood cell development from multipotent hematopoietic stem cells to specialized blood cells is accompanied by drastic changes in gene expression for which the triggers remain mostly unknown. Genetical genomics is an approach linking natural genetic variation to gene expression variation, thereby allowing the identification of genomic loci containing gene expression modulators (eQTLs). In this paper, we used a genetical genomics approach to analyze gene expression across four developmentally close blood cell types collected from a large number of genetically different but related mouse strains. We found that, while a significant number of eQTLs (365) had a consistent “static” regulatory effect on gene expression, an even larger number were found to be very sensitive to cell stage. As many as 1,283 eQTLs exhibited a “dynamic” behavior across cell types. By looking more closely at these dynamic eQTLs, we show that the sensitivity of eQTLs to cell stage is largely associated with gene expression changes in target genes. These results stress the importance of studying gene expression variation in well-defined cell populations. Only such studies will be able to reveal the important differences in gene regulation between different ce

Phase Space Reduction and Vortex Statistics: An Anyon Quantization Ambiguity

We examine the quantization of the motion of two charged vortices in a Ginzburg--Landau theory for the fractional quantum Hall effect recently proposed by the first two authors. The system has two second-class constraints which can be implemented either in the reduced phase space or Dirac-Gupta-Bleuler formalism. Using the intrinsic formulation of statistics, we show that these two ways of implementing the constraints are inequivalent unless the vortices are quantized with conventional statistics; either fermionic or bosonic.Comment: 14 pages, PHYZZ