Start Learning Chinese Words Fast: An Introduction

In order to cater to the needs of Chinese language lovers, 28 basic strokes of Chinese words are firstly introduced. It is pointed out that the difficulty for foreigners to learn Chinese words is their grotesque shapes written by brush (soft) pen and printed in books. The special writing method with a hard pen and 8 directions moving steps are invented and firstly shown, which is easy for foreigners to try. The size (length) of strokes will guide them to control the proportion of a word. It could be changed according to paper size and how large they want to write. Secondly, 48 common fragments derived from 28 basic strokes are listed and the writing method described. It could help foreigners to separate and re-write unknown Chinese words and even guess out the meanings. Lastly, many characteristics or regularities of Chinese words will have great attraction for foreign language learners. Some Chinese cultures or amusing stories are also exposed in fragments and example words

Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR4/ NF-κB pathway and protecting the intestinal barrier

Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase of the Toll-like receptor (TLR)-mediated pathway, considered a new target for treating inflammatory diseases. Studies showed a significant correlation between TLRs and inflammatory responses in ulcerative colitis (UC). Therefore, in this study, after inducing experimental colitis in mice with 3% dextran sulfate sodium (DSS), different concentrations of IRAK1/4 inhibitors were administered intraperitoneally. Then, the disease activity index was assessed, including the degree of pathological damage, by HE staining. Subsequently, while western blotting detected the TLR4/NF-κB pathway and intestinal barrier protein expression (Zonula-1, Occludin, Claudin-1, JAM-A), real-time polymerase chain reaction (RT-PCR) detected the mRNA expression levels of IRAK1/4 and mucin1/2. Furthermore, the expression levels of Zonula-1 and occludin were detected by immunofluorescence, including the plasma FITC-dextran 4000 concentration, to evaluate intestinal barrier permeability. However, ELISA measured the expression of inflammatory factors to reflect intestinal inflammation in mice. Investigations showed that the IRAK 1/4 inhibitor significantly reduced clinical symptoms and pathological DSS-induced colitis damage in mice and then inhibited the cytoplasmic and nuclear translocation of NF-κB p65, including the phosphorylation of IκBα and reduction in downstream inflammatory factor production. Therefore, we established that the IRAK1/4 inhibitor effectively improves colitis induced by DSS, partly by inhibiting the TLR4/NF-κB pathway, reducing inflammation, and maintaining the integrity of the colonic barrier

Fault-Tolerant Control of Magnetically-Levitated Rotor with Redundant Structures Based on Improved Generalized Linearized EMFs Model

Fault tolerance is one of the effective methods to improve the reliability of magnetic bearings, and the redundant magnetic bearing provides a feasible measure for fault-tolerant control. The linearization and accuracy of the electromagnetic force (EMF) from the redundant structures is crucial for designing fault-tolerant controllers. In the magnetic bearing with a redundant structure, the current distribution matrix W is an important factor that affects the accuracy of EMF. In this paper, we improved the accuracy of the EMF model and took the eight-pole symmetrical radial magnetic bearing as the research object. The corresponding displacement compensation matrices have been calculated for the different coils that fail in the magnetic bearing while the rotor is at the non-equilibrium position. Then, we propose a fault-tolerant control strategy that includes displacement compensation. The rigid body dynamics model of the rotor, supported by magnetic bearings with redundant structures, is established. Moreover, to verify the effectiveness of the proposed control strategy, we combined the rigid body dynamics model of the rotor with a fault-tolerant control strategy, and the corresponding simulation has been carried out. In the case of disturbance force and some coils fail in magnetic bearing and compared with the fault-tolerant control that absents the displacement compensation factors. The simulations demonstrate the disturbance rejection of magnetically levitated rotor system can be enhanced. The robustness of the rotor has been improved with the fault-tolerant control strategy proposed in this paper