A CCSD(T) study of the He〮NO molecular complex

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Heavier alkali-metal monosulfides (KS, RbS, CsS, and FrS) and their cations

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Sorafenib dose escalation is not uniformly associated with blood pressure elevations in normotensive patients with advanced malignancies.

Hypertension after treatment with vascular endothelial growth factor (VEGF) receptor inhibitors is associated with superior treatment outcomes for advanced cancer patients. To determine whether increased sorafenib doses cause incremental increases in blood pressure (BP), we measured 12-h ambulatory BP in 41 normotensive advanced solid tumor patients in a randomized dose-escalation study. After 7 days' treatment (400 mg b.i.d.), mean diastolic BP (DBP) increased in both study groups. After dose escalation, group A (400 mg t.i.d.) had marginally significant further increase in 12-h mean DBP (P = 0.053), but group B (600 mg b.i.d.) did not achieve statistically significant increases (P = 0.25). Within groups, individuals varied in BP response to sorafenib dose escalation, but these differences did not correlate with changes in steady-state plasma sorafenib concentrations. These findings in normotensive patients suggest BP is a complex pharmacodynamic biomarker of VEGF inhibition. Patients have intrinsic differences in sensitivity to sorafenib's BP-elevating effects

Structure and potential energy surface for Na⁺．N₂

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Spectroscopy of Na⁺．Rg and transport coefficients of Na⁺ in Rg(Rg＝He ―Rn)

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Theoretical study of Cl ‾ RG (rare gas) complexes and transport of Cl‾ through RG (RG = He-Rn)

2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Shift Work Is Not Associated with High Blood Pressure or Prevalence of Hypertension

Background: Working mostly at night has been suggested to be associated with upset of chronobiological rhythms and high blood pressure, but the evidence from epidemiological studies is weak. Methods: In a cross-sectional survey, we evaluated the association between shift work and blood pressure, pre-hypertension and hypertension. In total, 493 nurses, nurse technicians and assistants, were selected at random in a large general hospital setting. Hypertension was diagnosed by the mean of four automatic blood pressure readings $140/ 90 mmHg or use of blood pressure lowering agents, and pre-hypertension by systolic blood pressure$120–139 or diastolic blood pressure $80–89 mmHg. Risk factors for hypertension were evaluated by a standardized questionnaire and anthropometric measurements. The association between the shift of work and blood pressure, pre-hypertension and hypertension was explored using univariate and multivariate analyses that controlled for risk factors for hypertension by covariance analysis and modified Poisson regression. Results: The mean age of the participants was 34.369.4 years and 88.2 % were women. Night shift workers were older, more frequently married or divorced, and less educated. The prevalence of hypertension in the whole sample was 16%, and 28% had pre-hypertension. Blood pressure (after adjustment for confounding) was not different in day and night shift workers. The prevalence of hypertension and pre-hypertension by shift work was not different in the univariate analysis and afte

Evidence for Atmospheric Cold-trap Processes in the Noninverted Emission Spectrum of Kepler-13Ab Using HST/WFC3

We observed two eclipses of the Kepler-13A planetary system, on UT 2014 April 28 and UT 2014 October 13, in the near-infrared using Wide Field Camera 3 on the Hubble Space Telescope. By using the nearby binary stars Kepler-13BC as a reference, we were able to create a differential light curve for Kepler-13A that had little of the systematics typically present in HST/WFC3 spectrophotometry. We measure a broadband (1.1–1.65 μm) eclipse depth of 734 ± 28 ppm and are able to measure the emission spectrum of the planet at R ≈ 50 with an average precision of 70 ppm. We find that Kepler-13Ab possesses a noninverted, monotonically decreasing vertical temperature profile. We exclude an isothermal profile and an inverted profile at more than 3σ. We also find that the dayside emission of Kepler-13Ab appears generally similar to an isolated M7 brown dwarf at a similar effective temperature. Due to the relatively high mass and surface gravity of Kepler-13Ab, we suggest that the apparent lack of an inversion is due to cold-trap processes in the planet's atmosphere. Using a toy model for where cold traps should inhibit inversions, as well as observations of other planets in this temperature range with measured emission spectra, we argue that with more detailed modeling and more observations we may be able to place useful constraints on the size of condensates on the daysides of hot Jupiters

KIDMAP, a web based system for gathering patients' feedback on their doctors

<p>Abstract</p> <p>Background</p> <p>The gathering of feedback on doctors from patients after consultations is an important part of patient involvement and participation. This study first assesses the 23-item Patient Feedback Questionnaire (PFQ) designed by the Picker Institute, Europe, to determine whether these items form a single latent trait. Then, an Internet module with visual representation is developed to gather patient views about their doctors; this program then distributes the individualized results by email.</p> <p>Methods</p> <p>A total of 450 patients were randomly recruited from a 1300-bed-size medical center in Taiwan. The Rasch rating scale model was used to examine the data-fit. Differential item functioning (DIF) analysis was conducted to verify construct equivalence across the groups. An Internet module with visual representation was developed to provide doctors with the patient's online feedback.</p> <p>Results</p> <p>Twenty-one of the 23 items met the model's expectation, namely that they constitute a single construct. The test reliability was 0.94. DIF was found between ages and different kinds of disease, but not between genders and education levels. The visual approach of the KIDMAP module on the WWW seemed to be an effective approach to the assessment of patient feedback in a clinical setting.</p> <p>Conclusion</p> <p>The revised 21-item PFQ measures a single construct. Our work supports the hypothesis that the revised PFQ online version is both valid and reliable, and that the KIDMAP module is good at its designated task. Further research is needed to confirm data congruence for patients with chronic diseases.</p