Hume’s Academic Scepticism: A Reappraisal of His Philosophy of Human Understanding

A philosopher once wrote the following words:If I examine the PTOLOMAIC and COPERNICAN systems, I endeavour only, by my enquiries, to know the real situation of the planets; that is, in other words, I endeavour to give them, in my conception, the same relations, that they bear towards each other in the heavens. To this operation of the mind, therefore, there seems to be always a real, though often an unknown standard, in the nature of things; nor is truth or falsehood variable by the various apprehensions of mankind. Though all human race should for ever conclude, that the sun moves, and the earth remains at rest, the sun stirs not an inch from his place for all these reasonings; and such conclusions are eternally false and erroneous

The Understanding

The article discusses the varying conceptions of the faculty of ‘the understanding’ in 18th-century British philosophy and logic. Topics include the distinction between the understanding and the will, the traditional division of three acts of understanding and its critics, the naturalizing of human understanding, conceiving of the limits of human understanding, British innatism and the critique of empiricist conceptions of the understanding, and reconceiving the understanding and the elimination of scepticism. Authors discussed include Richard Price, James Harris, Zachary Mayne, Edward Bentham, Isaac Watts, Dugald Stewart, John Norris—as well as Locke, Berkeley, Hume and Reid

Interaction of staphylococci with bone

AbstractStaphylococci, in particular Staphylococcus aureus, are the predominant cause of bone infections worldwide. These infections are painful, debilitating and with the rise in antibiotic-resistant forms, increasingly difficult to treat. The growth in the number of prosthetic joint replacement procedures also provides new opportunities for these infections to take hold. Comprehending the mechanisms by which staphylococci interact with and damage bone is critical to the development of new approaches to meet this challenge. This review summarises current understanding of the mechanisms by which staphylococci infect and damage bone. We address the role of the inflammatory response to staphylococcal infection in disrupting the homeostatic balance of bone matrix deposition and resorption and thereby mediating bone destruction. A number of virulence factors that have been shown to contribute to bone infection and pathology are discussed, however no single factor has been defined as being specific to bone infections. Although traditionally considered an extracellular pathogen, there is increasing evidence that staphylococci are able to invade host cells, and that an intracellular lifestyle may facilitate long-term persistence in bone tissue, enabling evasion of antimicrobials and host immune responses. ‘Small colony variant’ strains, with mutations disabling the electron transport pathway appear particularly adept at invading and persisting within host cells, and exhibit enhanced antimicrobial resistance, and may represent a further complication in the treatment and management of staphylococcal bone disease

Conformations of Gas-Phase Ions of Ubiquitin, Cytochrome c, Apomyoglobin, and β-Lactoglobulin Produced from Two Different Solution Conformations

At low pH in solutions of 50% methanol, proteins form expanded denatured states (the “H” state). In 90% methanol, proteins form expanded helical denatured states with artificial α-helices (the “Hc” state). Gas-phase ions of ubiquitin, cytochrome c, apomyoglobin, and native and disulfide-reduced β-lactoglobulin were formed by electrospray ionization (ESI) of the proteins from the H and Hc states in solution. Both states in solution produce the same charge states in ESI. The conformations of the ions were studied with cross section measurements and gas-phase H/D exchange experiments. The cross sections show that the ions retain considerable folded structure. For a given protein and given charge state, ions produced from the H and Hc states showed the same cross sections (within ∼1%). Ions of cytochrome c, apomyoglobin, and native and reduced β-lactoglobulin of a given charge state showed no differences in H/D exchange level when produced from the H or Hc state. However, ubiquitin ions produced from the Hc state consistently exchange fewer (∼13%) hydrogens than ions produced from the H state, suggesting that in this case the gas-phase protein ions retain some memory of their solution conformations

Immigration and Ethnic Diversity in Nevada

In a few decades, non-Hispanic whites will constitute a bare majority in the United States. If current demographic trends continue, the Hispanic population will double or even triple in size by 2050, the Asian population will double, and the African-American population will grow at a faster pace than non-Hispanic whites, which are actually expected to begin declining by 2025. These developments promise to bring profound changes in the country’s ethnic and racial landscape

The non-pathogenic Australian rabbit calicivirus RCV-A1 provides temporal and partial cross protection to lethal Rabbit Haemorrhagic Disease Virus infection which is not dependent on antibody titres

The endemic non-pathogenic Australian rabbit calicivirus RCV-A1 is known to provide some cross protection to lethal infection with the closely related Rabbit Haemorrhagic Disease Virus (RHDV). Despite its obvious negative impacts on viral biocontrol of introduced European rabbits in Australia, little is known about the extent and mechanisms of this cross protection. In this study 46 rabbits from a colony naturally infected with RCV-A1 were exposed to RHDV. Survival rates and survival times did not correlate with titres of serum antibodies specific to RCV-A1 or cross reacting to RHDV, but were instead influenced by the time between infection with the two viruses, demonstrating for the first time that the cross protection to lethal RHDV infection is transient. These findings are an important step towards a better understanding of the complex interactions of co-occurring pathogenic and non-pathogenic lagoviruses