Long-range orbitofrontal and amygdala axons show divergent patterns of maturation in the frontal cortex across adolescence.

The adolescent transition from juvenile to adult is marked by anatomical and functional remodeling of brain networks. Currently, the cellular and synaptic level changes underlying the adolescent transition are only coarsely understood. Here, we use two-photon imaging to make time-lapse observations of long-range axons that innervate the frontal cortex in the living brain. We labeled cells in the orbitofrontal cortex (OFC) and basolateral amygdala (BLA) and imaged their axonal afferents to the dorsomedial prefrontal cortex (dmPFC). We also imaged the apical dendrites of dmPFC pyramidal neurons. Images were taken daily in separate cohorts of juvenile (P24-P28) and young adult mice (P64-P68), ages where we have previously discovered differences in dmPFC dependent decision-making. Dendritic spines were pruned across this peri-adolescent period, while BLA and OFC afferents followed alternate developmental trajectories. OFC boutons showed no decrease in density, but did show a decrease in daily bouton gain and loss with age. BLA axons showed an increase in both bouton density and daily bouton gain at the later age, suggesting a delayed window of enhanced plasticity. Our findings reveal projection specific maturation of synaptic structures within a single frontal region and suggest that stabilization is a more general characteristic of maturation than pruning

Aluminium-Free Glass Polyalkenoate Spinal Cements

Addition of Yitanium increased the Wt & St and the sf strength of these cements compared to the control (BT 101). © 2011 IEEE

The Effect of Adding Organic Polymers to Ca-Sr-Zn-Si Glass Polyalkenoate Cement

To conclude, the addition of polymers to GPCs resulted in little change to the Tw and Ts, however the compressive strength was found to decrease slightly. ASAP tests revealed that the cements may undergo some structural changes as a result of these additions. In the future perhaps the addition of organic polymers suspended in the liquid phase as part of the cement may yield improved results in this type of study. © 2011 IEEE

Comparison of a SiO2-CaO-ZnO-SrO Glass Polyalkenoate Cement to Commercial Dental Materials: Ion Release, Biocompatibility and Antibacterial Properties

Ion Release and biocompatibility of a CaO-SrO-ZnO-SiO2 (BT 101) based glass polyalkenoate cement (GPC) was compared against commercial GPCs, Fuji IX and Ketac Molar. The radiopacity (R) was similar for each material, 2.0-2.8. Ion release was evaluated on each material over 1, 7, 30 and 90 days. BT 101 release included Ca (23 mg/L), Sr (23 mg/L) Zn (13 mg/L), Si (203 mg/L). Fuji IX release includes Ca (0.7 mg/L), Al (3 mg/L) Si (26 mg/L), Na (60 mg/L) and P (0.5 mg/L) while Ketac Molar release includes Ca (1 mg/L), Al (0.6 mg/L) Si (23 mg/L), Na (76 mg/L) and P (0.7 mg/L). Simulated body fluid trials revealed CaP surface precipitation on BT 101. No evidence of precipitation was found on Fuji IX or Ketac Molar. Cytotoxicity testing found similar cell viability values for each material (~60 %, P = 1.000). Antibacterial testing determined a reduced CFU count with BT 101 (2.5 x 103) when compared to the control bacteria (2.4 x 104), Fuji IX (1.5 x 104) and Ketac Molar (1.2 x 104). © 2013 Springer Science+Business Media New York

A Spectroscopic Investigation into the Setting and Mechanical Properties of Titanium Containing Glass Polyalkenoate Cements

Titanium (Ti) implants are extensively used in a number of biomedical and dental applications. This work introduces Ti into the glass phase of a zinc-based glass polyalkenoate cement (GPC) and investigates changes in handling and mechanical properties considering two molecular weight polyacrylic acids (PAA), E9 and E11. Considering the handling properties, the working time (Tw) increased from 50 sE9, 32 sE11 (BT 101, Ti-free) to 169 sE9, 74 sE11 with TW-Z (highest Ti content), respectively. The setting time (Ts) increased from 76 sE9, 47 sE11 (BT 101) to 303 sE9, 232 sE11 with TW-Z, respectively. Ti was also found to have a significant increase on both compressive (σc) and biaxial flexural strength (σf), where σc increased from 36 MPaE9, 56 MPaE11 (BT 101) to 56 MPaE9 and 70 MPaE11 with TW-Z respectfully. σf also increased from 11 MPaE9, 22 MPaE11 (BT 101) to 22 MPaE9 and 77 MPaE11 with TW-Z, respectively. No increase in mechanical properties was evident with respect to maturation. Raman Spectroscopy was employed to investigate changes in glass structure and the setting of the cements with. This revealed increased glass network disruption with increasing TiO2 content and matured cement setting with TW-Z as compared to the control BT 101. FT-IR was then employed to investigate any additional setting mechanism and changes with time. Spectroscopy determined that Ca2+/Sr2+PAA complexes are primarily responsible for the setting and mechanical strength with no changes occurring over time

RAPTOR observations of delayed explosive activity in the high-redshift gamma-ray burst GRB 060206

The RAPid Telescopes for Optical Response (RAPTOR) system at Los Alamos National Laboratory observed GRB 060206 starting 48.1 minutes after gamma-ray emission triggered the Burst Alert Telescope (BAT) on-board the Swift satellite. The afterglow light curve measured by RAPTOR shows a spectacular re-brightening by ~1 mag about 1 h after the trigger and peaks at R ~ 16.4 mag. Shortly after the onset of the explosive re-brightening the OT doubled its flux on a time-scale of about 4 minutes. The total R-band fluence received from GRB 060206 during this episode is 2.3e-9 erg/cm2. In the rest frame of the burst (z = 4.045) this yields an isotropic equivalent energy release of ~0.7e50 erg in just a narrow UV band 130 +/- 22 nm. We discuss the implications of RAPTOR observations for untriggered searches for fast optical transients and studies of GRB environments at high redshift.Comment: Submitted to ApJ Letter

The Structural Characterization of Ga 2O 3-Na 2O-CaO-ZnO-SiO 2 Bioactive Glasses

The characterization of bioactive glasses in which zinc (Zn) has been incrementally replaced by gallium (Ga). © 2012 IEEE

Relating PH and Ion Release from Ga2O3-Na 2O-CaO-ZnO-SiO2 Bioactive Glasses

Three glasses were designed for this study, including one Ga-free glass (Control), and two Ga-containing glasses (TGa-1, TGa-2). In the Ga-containing glasses, Ga2O3 is included at the expense of ZnO. This study focuses on the relation between pH and ion concentration present in solution in which these bioactive glasses have been submerged for periods of 1, 7, and 14 days. © 2013 IEEE

A scalable machine-learning approach to recognize chemical names within large text databases

MOTIVATION: The use or study of chemical compounds permeates almost every scientific field and in each of them, the amount of textual information is growing rapidly. There is a need to accurately identify chemical names within text for a number of informatics efforts such as database curation, report summarization, tagging of named entities and keywords, or the development/curation of reference databases. RESULTS: A first-order Markov Model (MM) was evaluated for its ability to distinguish chemical names from words, yielding ~93% recall in recognizing chemical terms and ~99% precision in rejecting non-chemical terms on smaller test sets. However, because total false-positive events increase with the number of words analyzed, the scalability of name recognition was measured by processing 13.1 million MEDLINE records. The method yielded precision ranges from 54.7% to 100%, depending upon the cutoff score used, averaging 82.7% for approximately 1.05 million putative chemical terms extracted. Extracted chemical terms were analyzed to estimate the number of spelling variants per term, which correlated with the total number of times the chemical name appeared in MEDLINE. This variability in term construction was found to affect both information retrieval and term mapping when using PubMed and Ovid